Fitzpatrick's Dermatology in General Medicine. Vol 1

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9780071669047: Fitzpatrick's Dermatology in General Medicine. Vol 1
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Doody's 2015 Core Title!

The landmark dermatology text that bridges the gap between science and clinical medicine―updated for today’s practice

Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick’s as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. Edition after edition, it reflects the latest insights into skin diseases and skin biology―and their practical relevance to general internal medicine―while covering the scientific foundations of the specialty.

This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis.


  • More than 3000 full-color photographs
  • DVD with image bank includes downloadable figures from the text
  • New illustration style makes difficult concepts easier to understand
  • Therapeutic ladders with first, second, and third line therapies
  • New or thoroughly revised chapters on Psoriasis;Skin disease in immunosuppressed patients; Epidermal stem cells; Hair growth disorders; Neonatal, pediatric, and adolescent dermatology; Radiotherapy; Immunobiologicals and cytokines; Lasers for rejuvenation
  • Expanded medical and surgical therapeutics sections guide you through all treatment options

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Professor of Dermatology, University of North Carolina, Chapel Hill, NC
Dean Emeritus, University of Rochester School of Medicine and Dentistry, Rochester, NY


Section 1: General Considerations
1. The Epidemiology and Burden of Skin Disease, Martin A. Weinstock and Mary-Margaret Chren
2. Evidence-Based Dermatology, Michael Bigby, Rosamaria Corona, and Moyses Szklo
3. Global Health in Dermatology, Roderick Hay
4. Public Health in Dermatology, Hywell C. Williams, Sinead Langan, and Carsten Flohr
Section 2: Approach to Dermatologic Diagnosis
5. Structure of Skin Lesions and Fundamentals of Clinical Diagnosis, Amit Garg, Nikki A. Levin, and Jeffrey D. Bernhard
6. Basic Pathologic Reactions of the Skin, Klaus Wolff
Section 3: Overview of Biology, Development, and Structure of Skin
7. Development and Structure of Skin, David H. Chu
8. Genetics in Relation to the Skin, John McGrath and Irwin McLean
9. Racial Considerations: Skin of Color, Kavitha K. Reddy, Yolanda M. Lenzy, Katherine L. Brown, and Barbara A. Gilchrest
Section 4: Inflammatory Disorders Based on T-Cell Reactivity and Dysregulation
10. Innate and Adaptive Immunity for the Skin, Georg Stingl and Robert L. Modlin
11. Cytokines, Thomas Kupper and Ifor Williams
12. Chemokines, Anke S. Lonsdorf and Sam T. Hwang
13. Allergic Contact Dermatitis, Kathryn A. Zug and Mari Paz Castanedo
14. Atopic Dermatitis (Atopic Eczema), Donald Leung, Lawrence F. Eichenfield, and Mark Boguniewicz
15. Nummular Eczema and Lichen Simplex Chronicus/Prurigo Nodularis, Susan Burgin
16. Vesicular Palmoplantar Eczema, Daven N. Doshi, Carol E. Cheng, and Alexa B. Kimball
17. Autosensitization Dermatitis, Don Belsito
18. Psoriasis, James T. Elder
19. Psoriatic Arthritis, Dafna D. Gladman and Vinod Chandran
20. Reactive Arthritis, John D. Carter
21. Pustular Eruptions of Palms and Soles, Ulrich Mrowietz
22. Seborrheic Dermatitis, Chad M. Hivnor and Chris D. Collins
23. Exfoliative Dermatitis, Jane Margaret Grant-Kels, Flavia Fedeles, and Marti J. Rothe
24. Pityriasis Rubra Pilaris, Daniela Bruch-Gerharz and Thomas Ruzicka
25. Parapsoriasis and Pityriasis Lichenoides, Gary S. Wood, Chung-Hong Hu, and Rosemarie Liu
26. Lichen Planus, Mark R. Pittelkow and Mazen Daoud
27. Lichen Nitidus, Mark R. Pittelkow and Mazen Daoud
28. Graft-versus-Host Disease, Ed Cowen
29. Skin Disease in Acute and Chronic Immunosuppression, Benjamin D. Ehst and Andrew Blauvelt
Section 5: Inflammatory Diseases Based on Neutrophilsand Eosinophils
30. Regulation of the Production and Activation of Neutrophils, Steven M. Holland
31. Regulation of the Production and Activation of Eosinophils, Kristin M. Leiferman
32. Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome), Philip R. Cohen, Herbert Hönigsmann, and Razelle Kurzrock
33. Pyoderma Gangrenosum, Frank C. Powell, Bridget C. Hackett, and Daniel Wallach
34. Granuloma Faciale, David A. Mehregan and Darius R. Mehregan
35. Sub-Corneal Pustular Dermatosis (Sneddon-Wilkinson Disease), Franz Trautinger and Herbert Hönigsmann
36. Eosinophils in Cutaneous Diseases, Kristin M. Leiferman and Margot S. Peters
Section 6: Inflammatory Diseases Based on Abnormal Humoral Reactivity and Other Inflammatory Diseases
37. Humoral Immunity and Complement, Lela Lee
38. Urticaria and Angioedema, Allen Kaplan
39. Erythema Multiforme, Jean C. Roujeau
40. Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis), L. Valeyrie-Allanore and Jean C. Roujeau
41. Cutaneous Reactions to Drugs, Neil H. Shear and Sandra R. Knowles
42. Pityriasis Rosea, Andrew Blauvelt
43. Erythema Annulare Centrifugum and Other Figurate Erythemas, Walter H. C. Burgdorf
44. Granuloma Annulare, Julie S. Prendiville
Section 7: Disorders of Epidermal Differentiation and Keratinization
45. Epidermal Stem Cells, Rebecca Morris
46. Epidermal Growth and Differentiation, Tung-Tien Sun
47. Skin as an Organ of Protection, Ehrhardt Proksch and Jens-Michael Jensen
48. Irritant Contact Dermatitis, Antoine Amado, Apra Sood, and James S. Taylor
49. The Ichthyoses, Philip Fleckman and John DiGiovanna
50. Inherited Keratodermas of Palms and Soles, Mozheh Zamiri, Maurice A.M. van Steensel, and Colin S. Munro
51. Acantholytic Disorders of the Skin, Susan Burge and Alain Hovnanian
52. Porokeratosis, Alan D. Irvine and Grainne O'Regan
Section 8: Disorders of Epidermal and Dermal-Epidermal Cohesion and Vesicular and Bullous Disorders
53. Epidermal and Epidermal-Dermal Abrasion, Leena Bruckner-Tuderman and Aimee S. Payne
54. Pemphigus, John R. Stanley and Aimee S. Payne
55. Paraneoplastic Pemphigus, Grant Anhalt and Daniel Mimouni
56. Bullous Pemphigoid, Donna A. Culton, Zhi Liu, and Luis A. Diaz
57. Cicatricial Pemphigoid, Kim B. Yancey
58. Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood, Caroline L. Rao and Russell P. Hall, III
59. Pemphigoid Gestationis (Herpes Gestationis), Jeff Shornick
60. Epidermolysis Bullosa Acquisita, David T. Woodley and Mei Chen
61. Dermatitis Herpetiformis, Arash Ronaghy, Stephen I. Katz, and Russell P. Hall, III
62. Inherited Epidermolysis Bullosa, M. Peter Marinkovich
Section 9: Disorders of the Dermal Connective Tissue
63. Collagens, Elastic Fibers, and Other Extracellular Matrix Proteins of the Dermis, Thomas Krieg, Monique Aumailley, Manual Koch, Mon-Li Chu, and Jouni Uitto
64. Morphea, Stephanie Saxton-Daniels and Heidi Jacobe
65. Lichen Sclerosus, Ulrich Hengge
66. Dermal Hypertrophies and Benign Fibroblastic/Myofibroblastic Tumors, Christine Ko
67. Anetoderma and Other Atrophic Disorders of the Skin, Julie Powell and Catherine Maari
68. Ainhum and Pseudoainhum, Robert T. Brodell and Stephen E. Helms
69. Acquired Perforating Disorders, Bethanee Schlosser and Julia Minocha
Section 10: Disorders of Subcutaneous Tissue
70. Panniculitis, Iris K. Aronson, Patricia M. Fishman, and Sophie M. Worobec
71. Lipodystrophy, Abhimanyu Garg
Section 11: Disorders of Melanocytes
72. Biology of Melanocytes, Hee-Young Park, Marita G. Kosmadaki, Marinya Pongpudpunth, Jin Lee, and Mina Yaar
73. Albinism and Other Genetic Disorders of Pigmentation, Thomas J. Hornyak
74. Vitiligo, Stanca A. Birlea, Richard A. Spritz, and David A. Norris
75. Hypomelanoses and Hypermelanoses, Hilde Lapeere, Barbara Boone, Sofie De Schepper, Evelien Verhaeghe, Mireille Van Gele, Katia Ongenae, Nanja Van Geel, Jo Lambert, Lieve Brochez, and Jean-Marie Naeyaert
Section 12: Disorders of the Oral and Genital Integument
76. Biology and Pathology of the Oral Cavity, Sook-Bin Woo
77. Diseases and Disorders of the Male Genitalia, Christopher Barry Bunker
78. Diseases and Disorders of the Female Genitalia, Lynne Margesson and F. William Danby
Section 13: Disorders of the Sebaceous Glands
79. Biology of Sebaceous Glands, Amanda M. Nelson and Diane M. Thiboutot
80. Acne Vulgaris and Acneiform Eruptions, Andrea L. Zaenglein, Emmy M. Graber, Diane M. Thiboutot, and John S. Strauss
81. Rosacea, Michelle Terez Pelle
82. Perioral Dermatitis, Leslie P. Lawley and Sareeta R.S. Parker
Section 14: Disorders of the Eccrine and Apocrine Glands
83. Biology of Eccrine, Apocrine, and Apoeccrine Sweat Glands, Theodora Marie Mauro
84. Disorders of the Eccrine Sweat Glands and Sweating, Robert D. Fealey and Adelaide A. Herbert
85. Disorders of the Apocrine Sweat Glands, Christos C. Zouboulis and Fragkiski Tsatsou
Section 15: Disorders of the Hair and Nails
86. Biology of Hair Follicles, George Cotsarelis and Vladimir Botchkarev
87. Keratosis Pilaris and Other Inflammatory Follicular Keratotic Syndromes, Paradi Mirmirani and Maureen Rogers
88. Hair Growth Disorders, Nina Otberg and Jerry Shapiro
89. Biology of Nails and Nail Disorders, Antonella Tosti and Bianca Maria Piraccini
Section 16: Disorders Due to Ultraviolet Radiation
90. Fundamentals of Cutaneous Photobiology and Photoimmunology, Irene Kochevar, Charles Taylor, and Jean Krutmann
91. Abnormal Responses to Ultraviolet Radiation: Idiopathic, Probably Immunologic, and Photoexacerbated, Paul Bergstresser
92. Abnormal Responses to Ultraviolet Radiation: Photosensitivity Induced by Exogenous Agents, Henry W. Lim
Section 17: Skin Changes Due to Other Physical and Chemical Factors
93. Thermoregulation, Dean L. Kellogg, Jr.
94. Cold Injuries, Gérald E. Piéard, Pascale Quatresooz, and Claudine Piérard-Franchimont
95. Thermal Injuries, Robert L. Sheridan
96. Skin Problems in Amputees, Calum Lyon and Michael H. Beck
97. Skin Problems in Ostomates, Calum Lyon and Michael Beck
98. Corns and Calluses, Thomas M. DeLauro and Nicole M. DeLauro
99. Sports Dermatology, Dirk M. Elston
100. Decubitus (Pressure) Ulcers, Jennifer Gloeckner Powers, Lilian M. Odo, and Tania J. Phillips
101. Body Art, Anne Laumann
Section 18: Neurocutaneous and Psychocutaneous Skin Disease
102. Neurobiology of the Skin, Thomas Luger and Martin Steinhoff
103. Pathophysiology and Clinical Aspects of Pruritus, Gil Yosipovitch and Tejesh S. Patel
104. Psychocutaneous Skin Disease, Evan Rieder and Francisco A. Tausk
105. Cutaneous Manifestations of Drug Abuse, Richard A. Johnson and Haley Naik
106. Skin Signs of Physical Abuse, Howard Pride
Section 19: From Birth to Old Age
107. Neonatal, Pediatric, and Adolescent Dermatology, Mary W. Chang
108. Skin Changes and Diseases in Pregnancy, Julie K. Karen and Miriam Keltz Pomeranz
109. Aging of Skin, Barbara Ann Gilchrest and Mina Yaar
Section 20: Carcinogenesis
110. Genome Instability, DNA Repair, and Cancer, Kenneth H. Kraemer and Thomas M. Ruenger
111. Chemical Carcinogenesis, Andrzej A. Dlugosz
112. Ultraviolet Radiation Carcinogenesis, Masaoki Kawasumi and Paul Nghiem
Section 21: Epidermal and Appendageal Tumors
113. Epithelial Precancerous Lesions, Karyanne O. Duncan, John K. Geisse, and David J. Leffell
114. Squamous Cell Carcinoma, David J. Leffell and Douglas Grossman
115. Basal Cell Carcinoma, David J. Leffell and John Carucci
116. Basal Cell Nevus Syndrome, Anthony E. Oro and Jean Y. Tang
117. Keratoacanthoma, Lorenzo Cerroni and Helmut Kerl
118. Benign Epithelial Tumors, Hamartomas, and Hyperplasias, Neil Swanson
119. Appendage Tumors and Hamartomas of the Skin, Divya Srivastava and R. Stan Taylor
120. Merkel Cell Carcinoma, Andrew Tegeder, Olga Afanasiev, and Paul Nghiem
121. Mammary and Extramammary Paget Disease, Sherrif F. Ibrahim, Roy C. Greken, and Isaac M. Neuhaus
Section 22: Melanocytic Tumors
122. Benign Neoplasias and Hyperplasias of Melanocytes, James M. Grichnik, Arthur R. Rhodes, and Arthur J. Sober
123. Atypical (Dysplastic) Melanocytic Nevi, James Grichnik and Margaret A. Tucker
124. Cutaneous Melanoma, Evans C. Bailey, Arthur J. Sober, Hensin Tsao, Martin C. Mihm, Jr., and Timothy M. Johnson
Section 23: Tumors and Hyperplasias of the Dermis and Subcutaneous Fat
125. Malignant Fibrous, Fibrohistiocytic, and Histiocytic Tumors of the Dermis, Juergen C. Becker and Selma Ugurel
126. Vascular Tumors, Ilona J. Frieden and Erin Mathes
127. Neoplasias and Hyperplasias of Muscular and Neural Origin, Lucile E. White, Ross M. Levy, and Murad Alam
128. Kaposi Sarcoma, Erwin Tschachler
129. Neoplasms of Subcutaneous Fat, Thomas Brenn
Section 24: Skin in Nutritional, Metabolic, and Heritable Disease
130. Cutaneous Features of Nutritional Disease, Albert C. Yan and Melinda Jen
131. Cutaneous Changes in Errors of Amino Acid Metabolism, Peter Itin
132. The Porphyrias, David R. Bickers and Jorge Frank
133. Amyloidosis and the Skin, Helen J. Lachmann and Philip Hawkins
134. The Systemic Monogenic Autoinflammatory Diseases, Raphaela Goldbach-Mansky
135. Xanthomatoses and Lipoprotein Disorders, Ernst Schaefer and Raul Santos
136. Fabry Disease, Atul Mehta and Catherine H. Orteu
137. Lipoid Proteinosis and Heritable Disorders of Connective Tissue, Jon Dyer
138. Cutaneous Mineralization and Ossification, Janet Fairley
139. Hereditary Disorders of Genome Instability and DNA Repair, Thomas Ruenger, Kenneth H. Kraemer, and John DiGiovanna
140. Tuberous Sclerosis Complex, Thomas N. Darling
141. The Neurofibromatoses, Robert H. Listernick and Joel Charrow
142. Ectodermal Dysplasias, Nnenna Agim, Alanna F. Bree, and Virginia P. Sybert
143. Genetic Immunodeficiency Diseases, Ramsey Fuleihan and Amy Paller
Section 25: Skin Manifestations of Bone Marrow or Blood Chemistry Disorders
144. Hematologic Diseases, Warren Piette
145. Cutaneous Lymphoma, Marc Beyer and Wolfgang Sterry
146. Inflammatory Diseases That Simulate Lymphomas: Cutaneous Pseudolymphomas, Gary S. Wood
147. Cutaneous Langerhans Cell Histiocytosis, Carlo Gelmetti
148. Non-Langerhans Cell Histiocytosis, Carlo Gelmetti
149. Mastocytosis, Michael D. Thorp
Section 26: Skin Manifestations of Internal Organ Disorders
150. The Skin and Disorders of the Alimentary Trace, the Hepatobiliary System, Kidney and Cardiopulmonary System, Graham A. Johnston and Robin A.C. Graham-Brown
151. Diabetes Mellitus and Other Endocrine Diseases, Andrea A. Kalus, Andy J. Chien, and John E. Olerud
152. Sarcoidosis, Richard M. Marchell, Bruce Thiers, and Marc Judson
153. Cutaneous Manifestations of Internal Malignant Disease, Christine DeWitt, Lucinda Buescher, and Stephen P. Stone
Section 27: The Skin in Vascular and Connective Tissue and Other Autoimmune Disorders
154. Mechanisms of Autoimmune Disease, Joseph Craft and Inso...

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