Principles of Asymmetric Synthesis - Brossura

Gawley, Robert E.; Aube, Jeffrey

Brossura

ISBN 10: 0080448607 ISBN 13: 9780080448602

Casa editrice: Elsevier Science Ltd, 2012

Riassunto

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis, this book presents a detailed analysis of the factors that govern stereoselectivity in organic reactions.

After an explanation of the basic physical-organic principles governing stereoselective reactions, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Practical Aspects of Asymmetric Synthesis" provides a critical overview of the most common methods for the preparation of enantiomerically pure compounds, techniques for analysis of stereoisomers using chromatographic, spectroscopic, and chiroptical methods.

The authors then present an overview of the most important methods in contemporary asymmetric synthesis organized by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions, one chapter on reductions, and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). This organization allows the reader to compare the leading methods for asymmetric synthesis in an appropriate context.

A highlight of the book is the presentation and discussion of transition states at the current level of understanding, for important reaction types. In addition, extensive tables of examples are used to give the reader an appreciation for the scope of each reaction. Finally, leading references are provided to natural product synthesis that has been accomplished using a given reaction as a key step.

• Authoritative glossary to aid understanding of stereochemical terminology
• Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type
• A handy reference guide to the literature of asymmetric synthesis for practitioners in the field

Su questo libro

Recensione:

"...we have a wonderful second edition that not only retains the spirit of the original book, but is also comprehensive and comprehendible...Gawley’s legacy...lives on, not just in his own independent research, but in the number of chemists that this book and its first edition have inspired and those it will no doubt continue to inspire." -- Chemistry World, July 2013

L'autore:

Department of Medicinal Chemistry, University of North Carolina, USA

Su questa edizione

• Editore: Elsevier Science Ltd
• Data di pubblicazione: 2012
• ISBN 10: 0080448607
• ISBN 13: 9780080448602
• Rilegatura: Copertina flessibile
• Numero edizione: 2
• Numero di pagine: 555