Essential Hypertension and Its Causes: Neural and Non-Neural Mechanisms

Valutazione media 0
( su 0 valutazioni fornite da Goodreads )
 
9780195094831: Essential Hypertension and Its Causes: Neural and Non-Neural Mechanisms

This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latter's properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms.

Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hypertensive obesity. Stress is perceived by the cortex, from which increased dopaminergic (DA) neuron activity stimulates the hypothalamic defense area, raising sympathetic neural activity (SNA) and BP. Normally these subside quickly when the stress is over, but in those susceptible to EH the DA synapses become sensitized so that the defense response is evoked by ever lower levels of stress. Sensitization is common in memory circuits, but not in autonomic neurons, so that this property in EH may be genetically determined.

Stress-related hypertension increases hypothalamic responsiveness to high salt, resulting in further rises in SNA and BP. Later, non-neural functional changes (e.g. reduction in nitric oxide) and the structural remodeling of resistance vessels further enhance the vasoconstriction. In contrast, in those developing hypertensive obesity food consumption is excessive, which transiently alleviates stress-related anxiety. The brain ignores the leptin-mediated signals that normally curb appetite, contrasting with normal energy regulation in SSR-EH. In hypertensive obesity, the SNA pattern is similar to that in SSR-EH, but vasoconstriction is masked by vasodilatation and fluid retention due to hyperinsulinemia. This syndrome is a volume overload hypertension, where high cardiac output, renal impairment and other non-neural factors contribute to the elevation of BP.

Other topics include the role of various transmitters in autonomic regulation; the place of baroreflexes in the intact organism; why exercise training lowers resting BP; obstructive sleep apnea; non-pharmacological and drug treatment of EH; the role of the kidney in EH and in different types of renal hypertension and the pathogenesis of the Japanese spontaneously hypertensive rat, which provides a valuable animal model for EH.

The work suggests that physiological systems analysis in a complex disorder like EH is a valuable tool for using the great advances in molecular biology to best advantage.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

About the Author:


Paul Korner is Emeritus Professor of Medicine, Monash University, and Emeritus Director of the Baker Medical Research Institute. He was Foundation Professor of Physiology, University of New South Wales (1960-68); Scandrett Professor of Cardiology, University of Sydney (1968-1974); Director of the Baker Medical Research Institute and Professor of Medicine, Monash University (1975-1990).

Review:


"Dr. Korner successfully integrates vast amounts of information learned from research on the pathogenesis of essential hypertension into one comprehensive reference. Initial alterations of neural pressure regulatory system are expertly detailed providing targeted areas for expanded research."--Doody's


"...an invaluable resource to physicians and researchers in hypertension."--British Journal of Hospital Medicine


"Overall Essential Hypertension and Its Causes offers a fresh perspective on the putative causes of hypertension. This perspective may shift the focus of some research to the further illumination of neural mechanisms in the hope of finding new therapeutic measures - or perhaps a way to prevent essential hypertension altogether."--New England Journal of Medicine


"...We have long been missing the publication of books giving a strong,personal, even if controversial, general view of hypertension, such as those once authored by Volhard, Pickering and Page. Now, Paul Korner has provided one."--Journal of Hypertension


"This is a rare treat. After a lifetime of research and scholarship one of our best scientists plants a stake in the ground and.. gets into a serious and erudite analysis of the world's greatest preventable health problem. Essential Hypertension and Its Causes offers a synthesis which can never be gained from a standard text book. It will appeal to all those with a serious interest in hypertension."--Heart, Lung, and Circulation


Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

I migliori risultati di ricerca su AbeBooks

1.

Paul I. Korner
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Quantità: > 20
Print on Demand
Da
BWB
(Valley Stream, NY, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Condizione libro: New. This item is Print on Demand - Depending on your location, this item may ship from the US or UK. Codice libro della libreria POD_9780195094831

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 85,57
Convertire valuta

Aggiungere al carrello

Spese di spedizione: GRATIS
Da: U.S.A. a: Italia
Destinazione, tempi e costi

2.

Korner, Paul
Editore: Oxford University Press (2016)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Paperback Quantità: 1
Print on Demand
Da
Ria Christie Collections
(Uxbridge, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Oxford University Press, 2016. Paperback. Condizione libro: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Codice libro della libreria ria9780195094831_lsuk

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 84,69
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 4,92
Da: Regno Unito a: Italia
Destinazione, tempi e costi

3.

Korner, Paul I.
Editore: OUP USA (2007)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Quantità: > 20
Print on Demand
Da
Pbshop
(Wood Dale, IL, U.S.A.)
Valutazione libreria
[?]

Descrizione libro OUP USA, 2007. HRD. Condizione libro: New. New Book.Shipped from US within 10 to 14 business days.THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice libro della libreria IP-9780195094831

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 93,37
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 9,89
Da: U.S.A. a: Italia
Destinazione, tempi e costi

4.

Korner, Paul I.
Editore: OUP USA (2007)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Quantità: > 20
Print on Demand
Da
Books2Anywhere
(Fairford, GLOS, Regno Unito)
Valutazione libreria
[?]

Descrizione libro OUP USA, 2007. HRD. Condizione libro: New. New Book. Delivered from our US warehouse in 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND.Established seller since 2000. Codice libro della libreria IP-9780195094831

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 95,03
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 11,15
Da: Regno Unito a: Italia
Destinazione, tempi e costi

5.

Paul I. Korner
Editore: Oxford University Press Inc, United States (2007)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Rilegato Quantità: 10
Print on Demand
Da
The Book Depository
(London, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Oxford University Press Inc, United States, 2007. Hardback. Condizione libro: New. Language: English . Brand New Book ***** Print on Demand *****.Essential hypertension (EH) is the most common type of high blood pressure and is responsible for much death and serious illness, which has been the reason for the huge research effort to determine its causes. However, countless scientific articles still keep proclaiming that the causes of essential hypertension remain unknown. In view of the number of publications that descend on the hypertension specialist like a waterfall, such proclamations seem to overlook the considerable amount of knowledge that we already have about the etiology of EH. The problem may be a lack of synthesis rather than a lack of information. This book provides a unique synthesis of the pathophysiology of essential hypertension (EH), which is limited through the brain and is critically dependent on both genetic and environmental factors such as stress, high salt intake and obesity. Korner analyses the mechanisms by which the various factors raise blood pressure and the pathophysiology of EH compared with that in renal hypertension and in some of the rat models of genetic hypertension.In some individuals stress-induced vasoconstriction enhances the brain s responsiveness to salt, giving rise to stress-and-salt-related EH. In others, stress-induced EH promotes eating, causing hypertensive obesity. Improving lifestyle through regular exercise and reduction of salt and calorie intake directly antagonises the environmental causes of EH, and has implications for prevenion and treatment. Codice libro della libreria APC9780195094831

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 122,45
Convertire valuta

Aggiungere al carrello

Spese di spedizione: GRATIS
Da: Regno Unito a: Italia
Destinazione, tempi e costi

6.

Paul I. Korner
Editore: Oxford University Press Inc, United States (2007)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Rilegato Quantità: 10
Print on Demand
Da
The Book Depository US
(London, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Oxford University Press Inc, United States, 2007. Hardback. Condizione libro: New. Language: English . Brand New Book ***** Print on Demand *****. Essential hypertension (EH) is the most common type of high blood pressure and is responsible for much death and serious illness, which has been the reason for the huge research effort to determine its causes. However, countless scientific articles still keep proclaiming that the causes of essential hypertension remain unknown. In view of the number of publications that descend on the hypertension specialist like a waterfall, such proclamations seem to overlook the considerable amount of knowledge that we already have about the etiology of EH. The problem may be a lack of synthesis rather than a lack of information. This book provides a unique synthesis of the pathophysiology of essential hypertension (EH), which is limited through the brain and is critically dependent on both genetic and environmental factors such as stress, high salt intake and obesity. Korner analyses the mechanisms by which the various factors raise blood pressure and the pathophysiology of EH compared with that in renal hypertension and in some of the rat models of genetic hypertension.In some individuals stress-induced vasoconstriction enhances the brain s responsiveness to salt, giving rise to stress-and-salt-related EH. In others, stress-induced EH promotes eating, causing hypertensive obesity. Improving lifestyle through regular exercise and reduction of salt and calorie intake directly antagonises the environmental causes of EH, and has implications for prevenion and treatment. Codice libro della libreria APC9780195094831

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 123,46
Convertire valuta

Aggiungere al carrello

Spese di spedizione: GRATIS
Da: Regno Unito a: Italia
Destinazione, tempi e costi

7.

Paul I. Korner
Editore: Oxford University Press, USA (2007)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Rilegato Quantità: 1
Da
Ergodebooks
(RICHMOND, TX, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Oxford University Press, USA, 2007. Hardcover. Condizione libro: New. Codice libro della libreria SONG0195094832

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 119,11
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 12,04
Da: U.S.A. a: Italia
Destinazione, tempi e costi

8.

Paul I. Korner
Editore: Oxford University Press, USA (2007)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Rilegato Quantità: 1
Da
Ergodebooks
(RICHMOND, TX, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Oxford University Press, USA, 2007. Hardcover. Condizione libro: New. 1. Codice libro della libreria DADAX0195094832

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 132,79
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 12,04
Da: U.S.A. a: Italia
Destinazione, tempi e costi

9.

Korner, Paul I.
Editore: Oxford University Press (2017)
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Rilegato Quantità: 2
Print on Demand
Da
Murray Media
(North Miami Beach, FL, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Oxford University Press, 2017. Hardcover. Condizione libro: New. This item is printed on demand. Codice libro della libreria P110195094832

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 130,00
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 17,19
Da: U.S.A. a: Italia
Destinazione, tempi e costi

10.

Paul I. Korner
Editore: Oxford University Press, USA
ISBN 10: 0195094832 ISBN 13: 9780195094831
Nuovi Rilegato Quantità: 20
Print on Demand
Da
BuySomeBooks
(Las Vegas, NV, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Oxford University Press, USA. Hardcover. Condizione libro: New. This item is printed on demand. Hardcover. 720 pages. This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latters properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms. Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hypertensive obesity. Stress is perceived by the cortex, from which increased dopaminergic (DA) neuron activity stimulates the hypothalamic defense area, raising sympathetic neural activity (SNA) and BP. Normally these subside quickly when the stress is over, but in those susceptible to EH the DA synapses become sensitized so that the defense response is evoked by ever lower levels of stress. Sensitization is common in memory circuits, but not in autonomic neurons, so that this property in EH may be genetically determined. Stress-related hypertension increases hypothalamic responsiveness to high salt, resulting in further rises in SNA and BP. Later, non-neural functional changes (e. g. reduction in nitric oxide) and the structural remodeling of resistance vessels further enhance the vasoconstriction. In contrast, in those developing hypertensive obesity food consumption is excessive, which transiently alleviates stress-related anxiety. The brain ignores the leptin-mediated signals that normally curb appetite, contrasting with normal energy regulation in SSR-EH. In hypertensive obesity, the SNA pattern is similar to that in SSR-EH, but vasoconstriction is masked by vasodilatation and fluid retention due to hyperinsulinemia. This syndrome is a volume overload hypertension, where high cardiac output, renal impairment and other non-neural factors contribute to the elevation of BP. Other topics include the role of various transmitters in autonomic regulation; the place of baroreflexes in the intact organism; why exercise training lowers resting BP; obstructive sleep apnea; non-pharmacological and drug treatment of EH; the role of the kidney in EH and in different types of renal hypertension and the pathogenesis of the Japanese spontaneously hypertensive rat, which provides a valuable animal model for EH. The work suggests that physiological systems analysis in a complex disorder like EH is a valuable tool for using the great advances in molecular biology to best advantage. This item ships from La Vergne,TN. Hardcover. Codice libro della libreria 9780195094831

Maggiori informazioni su questa libreria | Fare una domanda alla libreria

Compra nuovo
EUR 139,26
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 11,14
Da: U.S.A. a: Italia
Destinazione, tempi e costi

Vedi altre copie di questo libro

Vedi tutti i risultati per questo libro