The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place.
This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias.
For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.
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Gerd Kempermann is at Max Delbruck Center for Molecular Medicine, Berlin.Review:
Since most neurons of the human brain last throughout the life span, the discovery that in selected regions of the mammalian brain neurons can be produced during adulthood has fascinated both scientists and the general public. Because of the interesting conceptual and potential medical significance, more than the usual number of irreproducible claims and irresponsible promises have been made. This impressive monograph by Gerd Kempermann, a scientist who has devoted his entire research career to this important subject, is a must for those who seek a balance between hype and reality. The text is written with a keen sense of history and attention to details. It should be read by both specialists and the educated public. Pasko Rakic, Yale University
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Descrizione libro Oxford University Press, 2005. Hardcover. Condizione libro: New. Codice libro della libreria mon0000418327
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