Gene Genealogies, Variation And Evolution: A Primer in Coalescent Theory - Brossura

Hein, Jotun

Brossura

ISBN 10: 0198529961 ISBN 13: 9780198529965

Casa editrice: Oxford University Press, U.S.A., 2005

Riassunto

Coalescent theory tells us what gene genealogies are expected to look like if populations have different demographic histories - i.e, population size, structure, etc. The aim of this book is to provide an accessible introduction to Coalescent Theory with a view towards data analysis. Coalescent Theory has in the last two decades moved from being an obscure technique that appealed to mathematical population geneticists to a central tool in data analysis of D.N.A. sequences. The completion of the sequencing of the human genome and accompanying determination of S.N.Ps and haplotypes will increase its importance even further. This textbook, rich in examples and illustrations, is suitable for a graduate course in statistics, population-, molecular-, and medical genetics.

Su questo libro

Recensione

This book fills a very important gap, as the first general textbook to deal exclusively with coalescent theory. (Systematic Biology)

this book should be mandatory reading for any graduate student working on population-level molecular data. (Evolution)

an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. (Professor Montgomery Slatkin (Berkeley))

the authors are outstanding experts in the field, and the book is topical and timely. (Professor David Balding (Imperial College))

Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. (Professor Joe Felsenstein (University of Washington))

There has been a dire need for a good book introducing coalescent theory to biologists. Gene Genealogies,Variation and Evolution fills this important gap this book should be mandatory reading for any graduate student working on population-level molecular data. (Evolution 60/1)

Contenuti

• Preface
• The basic coalescent
• From genealogies to sequences
• Trees and topologies
• Extensions to the basic coalescent
• The coalescent with recombination
• Getting parameters from data
• LD Mapping and the coalescent
• Human evolution
• Appendix: Web based tools

Dettagli dell'edizione

• Editore: Oxford University Press, U.S.A.
• Data di pubblicazione: 2005
• Lingua: Inglese
• ISBN 10: 0198529961
• ISBN 13: 9780198529965
• Rilegatura: Copertina flessibile
• Numero di pagine: 292
• Contatto del produttore: non disponibile
• Persona responsabile: Ufficio Anagrafiche Messaggerie; ufficio.anagrafiche@meli.it; ; Via Verdi, 8; Assago Milano; 20090; Italia