Long-term Potentiation: Enhancing neuroscience for 30 years
In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?
This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.
Advance praise for Long Term Potentiation: "This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field." Colin Blakemore, University of Oxford
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Descrizione del libro
Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today
- T Bliss, G Collingridge & R Morris: Introduction
- Foreword by Colin Blakemore
- 1: P Andersen: A prelude to long-term potentiation
- 2: T Lomo: The discovery of long-term potentiation
- 3: T Bliss: A journey from neocortex to hippocampus
- 4: G Lynch: Long-term potentiation in the Eocene
- 5: B McNaughton: Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history
- 6: G Collingridge: The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation
- 7: R Morris: Long-term potentiation and memory
- 8: M Bear: Bidirectional synaptic plasticity: from theory to reality
- 9: Z Bortolotto, S Lauri, J Isaac & G Collingridge: Kainate receptors and the induction of mossy fibre long-term potentiation
- 10: D Johnston, B Christie, A Frick, R Gray, D Hoffman, L Schexnayder, S Watanabe & L-L Yuan: Active dendrites, potassium channels and synaptic plasticity
- 11: M Errington, P Galley & T Bliss: Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode
- 12: T Hosokawa, M Ohta, T Saito & A Fine: Imaging spatio-temporal patterns of long-term potentiation in mouse hippocampus
- 13: S Choi, J Klingauf & R Tsien: Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation
- 14: R Malinow: AMPA receptor trafficking and long-term potentiation
- 15: F Duprat, M Daw, W Lim, G Collingridge & J Isaac: GluR2 protein-protein interactions and the reulation of AMPA receptors during synaptic plasticity
- 16: R Nicoll: Expression mechanisms underlying long-term potentiation: a postsynaptic view
- 17: D Kullmann: Silent synapses: what are they telling us about long-term potentiation?
- 18: W Abraham: How long will long-term potentiation last?
- 19: K Harris, J Fiala & L Ostroff: Structural changes at dendritic spine synapses during long-term potentiation
- 20: E Schuman & S Murase: Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions
- 21: C Pittenger & E Kandel: In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus
- 22: C Barnes: Long-term potentiation and the ageing brain
- 23: R Morris, E Moser, G Riedel, S Martin, J Sandin, M Day and C O'Carroll: Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory
- 24: S Tonegawa, K Nakazawa & M Wilson: Genetic neuroscience of mammalian learning and memory
- 25: G Hedou & I Mansuy: Inducible molecular switches for the study of long-term potentiation
- 26: B Bozon, A Kelly, S Josselyn, A Silva, S Davis & S Laroche: MAPK, CREB and zif268 are all required for the consolidation of recognition memory
- New Directions
- 27: M Thomas & R Malenka: Synaptic plasticity in the mesolimbic dopamine system
- 28: M Rowan, I Klyubin, W Cullen & R Anwyl: Synaptic plasticity in animal models of early Alzheimer's disease
- 29: J Lisman: Long-term potentiation: outstanding questions and attempted synthesis
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