Highly active antiretroviral therapy (HAART) is a therapeutic intervention developed by clinicians and researchers in order to fight the HIV pandemic. It has contributed to a significant reduction in AIDS-related mortality and allowed many previously bed-ridden patients to live healthier, more productive lives. Until the advent of HAART in 1996, a diagnosis of HIV infection was considered a death sentence. A decade later, the disease has been transformed into a serious, yet potentially manageable, medical condition for thousands of people living with HIV/AIDS in the developed world - almost overnight creating a generation of "HIV Survivors" - and forged a global movement to ensure that its Lazarus-like benefit reaches millions more in the developing world.
This book reviews the achievements of HAART over the past decade, and explores the challenges that may arise in the future. It recounts key landmarks in the development and introduction of HAART from the perspective of clinicians, researchers, economists, sociologists, and public policy experts, including the co-discoverers of HIV, Luc Montagnier and Robert Gallo. It explores the evolution of the disease, the evolution of HIV treatment, and the economic, social, and public policy impacts of both HIV and the introduction of HAART.
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Recensione:
...an excellent book...of interest both to those with an existing knowledge and interest in HIV as well as those who have come to the subject more recently...provides a unique insight into the dramatic period surrounding the introduction of HAART and thoughtful insights into likely future developments. (Public Health)
Contenuti:
- Luc Montagnier & Robert Gallo: Foreword
- 1: José M Zuniga, Alan Whiteside, Amin Ghaziani & John G Bartlett: Introduction
- A Decade of HAART: Trials, Tribulations, and Successes
- 2: José M Zuniga & Amin Ghaziani: A world ravaged by a disease without HAART
- 3: Michel D Kazatchkine & Lieve Fransen: Turning the world on its ear: defining milestones on the road to HAART
- 4: Eduard J Beck & Rochelle P Walensky: Outcome and impact of 10 years of HAART
- 5: Arry Dieudonne, James A McIntyre, Federica Freginese, Carla Giaqutinto & James M Oleske: Highly Active Anti-Retroviral Therapy in HIV-infected children: a decade later
- HAART in High Human Development Countries
- 6: Kathleen Glenday, Kathy Petoumenos, Matthew G Law & David A Cooper: Country review: Australia
- 7: Marcelo J Wolff: Country review: Chile
- 8: Eva Wolf & Hans Jaeger: Country review: Germany
- 9: Renato Maserati: Country review: Italy
- 10: Renslow Sherer: Country review: United States of America
- 11: Frank J Palella Jr, Anne C Moorman, John T Brooks; John Phair, Lisa Jacobson, Roger Detels, Joseph Margolick & Charles Rinaldo: The HIV Outpatient Study (HOPS) and the Multicenter AIDS Cohort Study
- 12: Dominique Costagliola: The French Hospital Database on HIV (FHDH) ANRS CO.4
- 13: Jens D Lundgren, Ole Kirk & Amanda Mocroft: EuroSIDA: A prospective observational study of chronic HIV infection 13-1 Across the European continent
- 14: Huldrych F Günthard & Bernard Hirschel: The Swiss HIV Cohort (SHCS)
- 15: Mark Holodniy: The OPTIMA Cohort
- HAART in Medium Human Development Countries
- 16: Celso Ferreira Ramos-Filho & Cledy Eliana dos Santos: Country review: Brazil
- 17: Zhang Fu-Jie, Ray Y Chen, Selina N Lo and Ma Ye: Country review: China
- 18: Robin Wood & Des Martin: Country review: South Africa
- 19: Praphan Phanuphak, Sanchai Chasombat & Jintanat Ananworanich: Country review: Thailand
- 20: Mauro Schechter & Suely Hiromi Tuboi: Cohort studies in Brazil: Projet Praça Onze
- 21: Kiat Ruxrungtham: The HIV Netherlands-Australia-Thailand research collaboration (HIVNAT)
- HAART in Low Human Development Countries
- 22: Serena Koenig, Julia Carney, Peter Bendix & Jean William Pape: Country review: Haiti
- 23: Erik J Schouten, Simon D Makombe, Anthony D Harries & Kelita Kamoto: Country review: Malawi
- 24: Papa Salif Sow: Country review: Senegal
- 25: Moses Sinkala & Benjamin H Chi: Country review: Zambia
- Future Challenges in the Next Decade of HAART
- 26: Roger Paredes, Renslow Sherer & Bonaventura Clotet: Clinical challenges of lifetime HAART
- 27: Stephanie Nixon & Nina Veenstra: Maintaining and developing health systems to sustain HAART
- 28: Mario Roberto Dal Poz, Norbert Dreesch & Dingie van Rensburg: Redefining HIV/AIDS care delivery in the face of human resource scarcity
- 29: Peter Piot, Julian Fleet & Siddharth Dube: Conclusion: closing the gap - one world, one standard
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