Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery

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9780199309399: Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery

Venom research and technology has advanced greatly, rapidly transforming our knowledge of reptile venoms. Research advances, like the development of molecular systematics, provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments have expanded our understanding of venom's evolution and its usefulness in therapeutic development. The results of this punctuated toxin molecular evolutionary expansion include protein neofunctionalization. While these changes may impact antivenom efficacy, this molecular diversity also facilitates their usefulness in the development of novel drug therapies.

Venomous Reptiles And Their Toxins brings together the world's leading toxinologists in this comprehensive study of the entire scope of reptile venoms, from clinical effects to evolution to drug design and development. The book contains detailed applied chapters on clinical care of the envenomed patient, ineffective traditional or modern remedies, occupational considerations involved in the maintenance of institutional venomous reptile collections, veterinary care for venomous reptiles and research methods used in venom research. This book also devotes a chapter to each toxin class found in reptile venoms, detailing the full trajectory of research on the peptide or protein in question. These chapters discuss each toxin's respective role in the envenomation process through to how each has been explored for their biomedical potential. This book is a unique resource for anyone working with venomous reptiles.

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About the Author:


Bryan G. Fry is an Associate Professor in the School of Biological Sciences at the University of Queensland. He leads the Venom Evolution Laboratory, working on venoms from a wide diversity of reptiles, centipedes, cnidarians, insects, scorpions, spiders and even venomous mammals. He has published extensively on venom systems evolution and how they can be harnessed for therapeutic use. His discoveries include antifreeze venom in Antarctic octopuses, komodo dragon venom and new species of sea snakes. Fry's publications have appeared in prestigious scientific journals, including Nature. He has led field expeditions to over forty countries and he is a member of the Explorers Club. His work has been featured in over seventy natural history documentaries appearing on Animal Planet, BBC, Discovery Channel, National Geographic TV and others.

Fry has a B.Sc. (honours) in Molecular Biology, a B.A. (honours) in Scientific Philosophy, as well as B.A. minor studies in Psychology from Portland State University. Subsequently he obtained a Ph.D. in Biochemistry from the University of Queensland, Institute for Molecular Biosciences (Centre for Drug Design and Development). His work has been funded by grants from a diversity of funding agencies, including the Australian Research Council and the Australian Antarctic Division.

Review:


"This volume is a major contribution to toxinology. ... Fry's book will not create universal consensus, but it will stimulate debate, essential for all good science. ... Highly recommended for collections in herpetology and toxinology." --CHOICE


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Descrizione libro Oxford University Press Inc, United States, 2015. Hardback. Condizione libro: New. Language: English . Brand New Book. Venom research and technology has advanced greatly, rapidly transforming the area of reptile venom. Research developments-like the development of molecular systematics-provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments result in a fundamental shift in scientists understanding of venom s evolution and usefulness in therapeutic development. Startling evolutionary expansion, including the development of new protein functions, enable the development of novel drug therapies and impact the effectiveness of anti-venoms available for the treatment of humans. Venomous Reptiles And Their Toxins is a comprehensive study of the entire scope of reptile venom, from its evolution to drug design and development. This book devotes a chapter to each toxin class found in reptile venom, detailing the full trajectory of research on the toxin in question. The comprehensive synthesis of research deals with the impact that venom has had on biomedical applications and snake evolution and ecology. Codice libro della libreria AOP9780199309399

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Descrizione libro Oxford University Press Inc, United States, 2015. Hardback. Condizione libro: New. Language: English . Brand New Book. Venom research and technology has advanced greatly, rapidly transforming the area of reptile venom. Research developments-like the development of molecular systematics-provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments result in a fundamental shift in scientists understanding of venom s evolution and usefulness in therapeutic development. Startling evolutionary expansion, including the development of new protein functions, enable the development of novel drug therapies and impact the effectiveness of anti-venoms available for the treatment of humans. Venomous Reptiles And Their Toxins is a comprehensive study of the entire scope of reptile venom, from its evolution to drug design and development. This book devotes a chapter to each toxin class found in reptile venom, detailing the full trajectory of research on the toxin in question. The comprehensive synthesis of research deals with the impact that venom has had on biomedical applications and snake evolution and ecology. Codice libro della libreria AOP9780199309399

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Descrizione libro Oxford University Press Inc. Hardback. Condizione libro: new. BRAND NEW, Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery, Bryan Fry, Venom research and technology has advanced greatly, rapidly transforming the area of reptile venom. Research developments-like the development of molecular systematics-provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments result in a fundamental shift in scientists' understanding of venom's evolution and usefulness in therapeutic development. Startling evolutionary expansion, including the development of new protein functions, enable the development of novel drug therapies and impact the effectiveness of anti-venoms available for the treatment of humans. Venomous Reptiles And Their Toxins is a comprehensive study of the entire scope of reptile venom, from its evolution to drug design and development. This book devotes a chapter to each toxin class found in reptile venom, detailing the full trajectory of research on the toxin in question. The comprehensive synthesis of research deals with the impact that venom has had on biomedical applications and snake evolution and ecology. Codice libro della libreria B9780199309399

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Descrizione libro Oxford University Press, 2015. Condizione libro: New. A comprehensive study of the chemical and biological properties of reptile venom. Editor(s): Fry, Bryan. Num Pages: 576 pages, With 89 illustrations. BIC Classification: PSVW5. Category: (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 186 x 261 x 35. Weight in Grams: 1272. . 2015. 1st Edition. Hardcover. . . . . . Codice libro della libreria V9780199309399

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