Molecularly Targeted Therapy for Childhood Cancer

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9780387690605: Molecularly Targeted Therapy for Childhood Cancer

Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular 'drivers' can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

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Molecularly-Targeted Therapy for Childhood Cancer is a comprehensive exploration of the molecular aspects of childhood cancers that are currently being targeted therapeutically or are in the early phases of development. Each chapter describes key molecular characteristics of hematopoietic malignancies and solid tumors in children and young adults that are fundamental to the etiology, survival and drug resistance of these cancers as well as able to serve as tumor selective pathways for treatment. There has never been a more optimal time to explore the current and future use of molecularly targeted therapies in pediatric oncology. Conventional chemotherapeutic approaches have been dose intensified to such an extent that acute and late toxicities have reached maximal points while the rate of cure has slowed. The volume moves beyond conventional chemotherapeutic approaches to explore approaches that target tumor selective molecular and immunologic characteristics. The chapters further explore how such targeted therapies can begin to be integrated with conventional regimens in order to improve efficacy while reducing morbidity. While molecularly targeted therapies have generated great excitement in the world of oncology, their impact for pediatric patients may provide some of the greatest impact in part because of their developmental susceptibilities to conventional cytotoxic treatments. In addition, less toxic and more effective therapies hold great promise for improving the outcome of pediatric patients in developing countries where supportive care measures may not always be optimal. Molecularly-Targeted Therapy for Childhood Cancer is thus a timely first foray into the world of targeted, pathway directed treatment approaches for pediatric patients with cancer and brings us one step closer to the day when Paul Erhlich’s hope for therapeutic Magic Bullets becomes the conventional approach to cure.

Contenuti:

Hematologic Malignancies.- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia.- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia.- Molecularly Targeted Therapy for Infant ALL.- Targeted Therapeutic Approaches for AML.- Acute Promyelocytic Leukaemia.- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy.- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML).- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics.- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes.- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma.- Molecular Targeting of Post-transplant Lymphoproliferative Disorders.- Solid Tumors.- Molecularly Targeted Therapies for Astrocytomas.- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer.- Future Treatments of Ependymoma.- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor.- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors.- Molecular Therapy for Neuroblastoma.- Ewing’s Sarcoma Family of Tumors: Molecular Targets Need Arrows.- Molecular Targeted Therapy for Wilms’ Tumor.- Molecular Therapy for Rhabdomyosarcoma.- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here?.- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology.

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Houghton, Peter J.
Editore: Springer (2016)
ISBN 10: 0387690603 ISBN 13: 9780387690605
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Descrizione libro Springer, 2016. Paperback. Condizione libro: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Codice libro della libreria ria9780387690605_lsuk

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PETER J. HOUGHTON
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Descrizione libro Springer, 2010. Hardback. Condizione libro: NEW. 9780387690605 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Codice libro della libreria HTANDREE0273754

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Descrizione libro Springer-Verlag New York Inc., 2007. HRD. Condizione libro: New. New Book. Delivered from our US warehouse in 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice libro della libreria I1-9780387690605

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Descrizione libro Springer-Verlag New York Inc., 2007. HRD. Condizione libro: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice libro della libreria I1-9780387690605

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Editore: Springer (2010)
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Descrizione libro Springer, 2010. Condizione libro: New. This item is printed on demand for shipment within 3 working days. Codice libro della libreria LP9780387690605

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Descrizione libro Springer-Verlag New York Inc., United States, 2010. Hardback. Condizione libro: New. 2010 ed.. 234 x 155 mm. Language: English . Brand New Book ***** Print on Demand *****. Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular drivers can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies. Codice libro della libreria APC9780387690605

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Editore: Springer-Verlag New York Inc., United States (2010)
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Descrizione libro Springer-Verlag New York Inc., United States, 2010. Hardback. Condizione libro: New. 2010 ed.. 234 x 155 mm. Language: English . Brand New Book ***** Print on Demand *****.Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular drivers can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies. Codice libro della libreria APC9780387690605

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Descrizione libro Condizione libro: New. This item is Print on Demand - Depending on your location, this item may ship from the US or UK. Codice libro della libreria POD_9780387690605

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Descrizione libro Springer, 2010. Hardcover. Condizione libro: New. book. Codice libro della libreria 0387690603

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Descrizione libro Springer. Hardcover. Condizione libro: New. Hardcover. 536 pages. Dimensions: 9.2in. x 6.1in. x 1.3in.Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular drivers can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Hardcover. Codice libro della libreria 9780387690605

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