Mechanisms of Tumor Escape from the Immune Response (Tumor Immunology and Immunotherapyseries, 1)

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9780415282079: Mechanisms of Tumor Escape from the Immune Response (Tumor Immunology and Immunotherapyseries, 1)

The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system. Moreover, the inability to achieve in humans the unequivocal success of immunotherapy in murine models suggests the possibility that cancer can impair the development of a therapeutic immune response.
Scientific and technological advances in cellular and molecular biology during the last two decades have provided new tools with which to explore the dysfunctional immune system of patients with cancer. Novel immunology concepts have provided new insights into changes occurring in tumor cells and the immune system, providing a more cohesive understanding of the process, including:
*diminished or absent expression of HLA antigens and co-stimulatory molecules
*arrested maturation of dentritic cells
*alterations in expression of some signal transduction proteins
*increased apoptosis in T and NK cells
*presence of suppressor CD+4 and CD25+ T cells

Mechanisms of Tumor Escape from the Immune Response provides an introduction to this rapidly developing and, as yet, unsettled area of cancer research, and will be a valuable reference for clinicians and researchers working in the field of cancer immunotherapy.

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Editore: Taylor Francis Ltd, United Kingdom (2003)
ISBN 10: 0415282071 ISBN 13: 9780415282079
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Descrizione libro Taylor Francis Ltd, United Kingdom, 2003. Hardback. Condizione libro: New. Language: English . Brand New Book. The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system. Moreover, the inability to achieve in humans the unequivocal success of immunotherapy in murine models suggests the possibility that cancer can impair the development of a therapeutic immune response. Scientific and technological advances in cellular and molecular biology during the last two decades have provided new tools with which to explore the dysfunctional immune system of patients with cancer.Novel immunology concepts have provided new insights into changes occurring in tumor cells and the immune system, providing a more cohesive understanding of the process, including: *diminished or absent expression of HLA antigens and co-stimulatory molecules *arrested maturation of dentritic cells *alterations in expression of some signal transduction proteins *increased apoptosis in T and NK cells *presence of suppressor CD+4 and CD25+ T cells Mechanisms of Tumor Escape from the Immune Response provides an introduction to this rapidly developing and, as yet, unsettled area of cancer research, and will be a valuable reference for clinicians and researchers working in the field of cancer immunotherapy. Codice libro della libreria AA69780415282079

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Editore: CRC Press (2002)
ISBN 10: 0415282071 ISBN 13: 9780415282079
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Descrizione libro CRC Press, 2002. HRD. Condizione libro: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Codice libro della libreria FT-9780415282079

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Editore: Taylor Francis Ltd, United Kingdom (2003)
ISBN 10: 0415282071 ISBN 13: 9780415282079
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Descrizione libro Taylor Francis Ltd, United Kingdom, 2003. Hardback. Condizione libro: New. Language: English . Brand New Book. The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system. Moreover, the inability to achieve in humans the unequivocal success of immunotherapy in murine models suggests the possibility that cancer can impair the development of a therapeutic immune response. Scientific and technological advances in cellular and molecular biology during the last two decades have provided new tools with which to explore the dysfunctional immune system of patients with cancer. Novel immunology concepts have provided new insights into changes occurring in tumor cells and the immune system, providing a more cohesive understanding of the process, including: *diminished or absent expression of HLA antigens and co-stimulatory molecules *arrested maturation of dentritic cells *alterations in expression of some signal transduction proteins *increased apoptosis in T and NK cells *presence of suppressor CD+4 and CD25+ T cells Mechanisms of Tumor Escape from the Immune Response provides an introduction to this rapidly developing and, as yet, unsettled area of cancer research, and will be a valuable reference for clinicians and researchers working in the field of cancer immunotherapy. Codice libro della libreria AA69780415282079

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Descrizione libro Taylor & Francis Ltd. Hardback. Condizione libro: new. BRAND NEW, Mechanisms of Tumor Escape from the Immune Response, A. Ochoa, The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system. Moreover, the inability to achieve in humans the unequivocal success of immunotherapy in murine models suggests the possibility that cancer can impair the development of a therapeutic immune response. Scientific and technological advances in cellular and molecular biology during the last two decades have provided new tools with which to explore the dysfunctional immune system of patients with cancer. Novel immunology concepts have provided new insights into changes occurring in tumor cells and the immune system, providing a more cohesive understanding of the process, including: *diminished or absent expression of HLA antigens and co-stimulatory molecules *arrested maturation of dentritic cells *alterations in expression of some signal transduction proteins *increased apoptosis in T and NK cells *presence of suppressor CD+4 and CD25+ T cells Mechanisms of Tumor Escape from the Immune Response provides an introduction to this rapidly developing and, as yet, unsettled area of cancer research, and will be a valuable reference for clinicians and researchers working in the field of cancer immunotherapy. Codice libro della libreria B9780415282079

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Ochoa, Augustus C.
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ISBN 10: 0415282071 ISBN 13: 9780415282079
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Descrizione libro Taylor & Francis Ltd 2002-12-12, London, 2002. hardback. Condizione libro: New. Codice libro della libreria 9780415282079

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Ochoa, A
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Descrizione libro Taylor Fransis. Condizione libro: New. Brand New. Codice libro della libreria 0415282071

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Descrizione libro 2002. HRD. Condizione libro: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Codice libro della libreria VT-9780415282079

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OCHOA, A.
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Descrizione libro CRC Press, 2002. Hardback. Condizione libro: NEW. 9780415282079 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Codice libro della libreria HTANDREE0193200

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Ochoa, Augustus C.
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Descrizione libro Routledge, 2003. Hardcover. Condizione libro: Brand New. 1st edition. 304 pages. 10.00x7.25x0.75 inches. In Stock. Codice libro della libreria __0415282071

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Descrizione libro CRC Press, 2002. Hardcover. Condizione libro: New. book. Codice libro della libreria 0415282071

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