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ISBN 10: 0443071454 ISBN 13: 9780443071454

Casa editrice: Churchill Livingstone, 2003

Riassunto

Pharmacology is now established as a worldwide best-selling and highly acclaimed textbook for medical and science students In this fifth edition, as in the previous four, the approach has been not just to describe what drugs do but to emphasise the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and new ones appear each year. An appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a good starting point for understanding and using the new compound intelligently.

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Pharmacology is a lively scientific discipline in its own right, with an importance beyond that of providing a basis for the use of drugs in therapy. The book therefore, where appropriate, includes brief coverage of the use of drugs as probes for elucidating cellular and physiological functions, even when the compounds have no clinical uses.

The fifth edition retains the short summaries of relevant physiological and biochemical processes placed at the beginning of most chapters to form a basis for the subsequent discussion of pharmacological actions. As before, short sets of key points are placed in boxes throughout the text. These are not intended as comprehensive summaries but rather to highlight pharmacological information that the authors consider important. Factual knowledge in pharmacology is so extensive and expanding so rapidly that students can easily find the information load daunting, and these key points are intended to make it easier for students to gets to grips with the essentials of the subject. As in the previous edition, the therapeutic use of drugs has been given prominence by setting it out in easily identified 'clinical boxes'.

For the Fifth Edition the book is presented in full colour with a new page format and design. Most diagrams have been updated and all have been redrawn in colour, while many new figures have been added. Continuing the approach used in earlier editions the illustrations, wherever feasible, use real data rather than notional information. As previously, the emphasis is placed on the chemical structures of drugs for where this information helps in understanding how the drugs act.

All chapters have been updated and an 'Overview' section has been introduced at the beginning of each to help the reader get a flying start on that topic. In including new material, the book takes into account not only new agents but also recent extensions of basic knowledge which presage further drug development, and, where possible, gives a brief outline of new treatments in the pipeline. New 'small print' sections have been included in many chapters. These contain more detailed, sometimes speculative, material, which can be skipped by the reader in a hurry without losing the main thread, but will be of interest to readers wishing to go into greater depth.

As before, the book includes fairly extensive sections on 'References and further reading' at the end of each chapter. Because the medical curriculum stresses project work and the preparation of special study modules, references have been annotated to emphasize the main aspects of their coverage and so make the Reference section easier for students to use.

Su questo libro

Contenuti:

I. GENERAL PRINCIPLES
1. What is pharmacology?
2. How drugs act: general principles
3. How drugs act: molecular aspects
4. Cellular mechanisms: excitation, contraction, and secretion
5. Cellular mechanisms: cell proliferation and apoptosis
6. Method and measurement in pharmacology
7. Absorption and distribution of drugs
8. Drug elimination and pharmacokinetics

II. CHEMICAL MEDIATORS
9. Chemical mediators and the autonomic nervous system
10. Cholinergic transmission
11. Noradrenergic transmission
12. Other peripheral mediators
13. Peptides and proteins as mediators
14. Nitric oxide
15. Local hormones, inflammation, and immune reactions
16. Anti-inflammatory and immunosuppressant drugs

III. DRUGS AFFECTING MAJOR ORGAN SYSTEMS
17. The heart
18. The vascular system
19. Atherosclerosis and lipoprotein metabolism
20. Haemostasis and thrombosis
21. The haemopoietic system
22. The respiratory system
23. The kidney
24. The gastrointestinal tract
25. The endocrine pancreas and the control of blood glucose
26. Obesity
27. The pituitary and adrenal cortex
28. The thyroid
29. The reproductive system
30. Bone metabolism

IV. THE NERVOUS SYSTEM
31. Chemical transmission and drug action in the central nervous system
32. Amino acid transmitters
33. Other transmitters and modulators
34. Neurodegenerative disorders
35. General anaesthetic agents
36. Anxiolytic and hypnotic drugs
37. Antipsychotic drugs
38. Drugs used in affective disorders
39. Antiepileptic drugs
40. Analgesic drugs
41. Central nervous system stimulants and psychotomimetic drugs
42. Drug dependence and drug abuse
43. Local anaesthetics

V. DRUGS USED IN THE TREATMENT OF INFECTIONS AND CANCER
44. Basic principles of chemotherapy
45. Antibacterial drugs
46. Antiviral drugs
47. Antifungal drugs
48. Antiprotozoal drugs
49. Antihelminthic drugs
50. Cancer chemotherapy

VI. SPECIAL TOPICS
51. Individual variation and drug interaction
52. Harmful effects of drugs
53. Gene therapy
54. Drug discovery and development

Appendix

Index

Product Description:

Book by Rang MB MS MA DPhil FMedSci FRS Hon FBPharmacolS H

Su questa edizione

• Editore: Churchill Livingstone
• Data di pubblicazione: 2003
• ISBN 10: 0443071454
• ISBN 13: 9780443071454
• Rilegatura: Copertina flessibile
• Numero edizione: 5
• Numero di pagine: 816