Life's Greatest Secret: The Race to Crack the Genetic Code

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9780465062676: Life's Greatest Secret: The Race to Crack the Genetic Code


Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life's) future.

Life's Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters—mathematicians, physicists, information theorists, and biologists—who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or “junk DNA” was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb's telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who'd like to explore those questions for themselves.

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Recensione:

“The third of the grand unifying theories of biology was completed in the 20th Century, following Darwin's evolution by natural selection, and Cell Theory a century earlier. DNA, the double helix, and the universality of the genetic code radically transformed our understanding of life: no area in biology has been untouched by this revolution, from cancer to human origins to genetic engineering, and now, to the future of data storage. Cobb, a scientist and thorough historian, is a master storyteller, and recounts the thrilling science, politics, egos of this grand scientific revolution. Essential, definitive reading.”
—Adam Rutherford, author of Creation: How Science Is Reinventing Life Itself

“Most people think the race to sequence the human genome culminated at the 2000 White House “Mission Accomplished” announcement. In Matthew Cobb's Life's Greatest Secret, we learn that it was just one chapter of a far more interesting and continuing story.”
—Eric Topol, Professor of Genomics and Director, Scripps Translational Science Institute and author of The Patient Will See You Now

“[T]he cracking of the code of life is a great story, of which this is an accomplished telling.”
Economist

“Readers of Mr. Cobb's book will learn much about the history and current state of modern biology.”
Wall Street Journal

“A lucid explanation of the science and the stories of key players.”
Nature

“An authoritative but nevertheless thrilling narrative…In short, this is a first-class read.”
The Observer

“[A] masterly account… Cobb's book is a delight. Even those who know parts of the story quite well will find fresh, intriguing vignettes.”
Guardian

“Cobb covers well-plowed ground, but he does so in a manner both thoroughly engaging and truly edifying.”
Publishers Weekly

“Like Cobb's other titles, this scholarly work reflects extensive research and draws upon primary documents. Upper-level students and researchers in biology or the history of science are best equipped to appreciate this detailed book.”
Library Journal

“[A] fine history of genetics.... [A] gripping, insightful history, often from the mouths of the participants themselves.”
Kirkus Reviews (starred)

PRAISE FOR LIFE'S GREATEST SECRET:

Named one of the best science books of 2015 by the Guardian

“The book serves as a useful primer for those interested in the brave new world of genetic intervention made possible by the rise of biotechnology. But Cobb's book will also be of interest to professional scientists as it recounts events in one of the most transformative periods in the history of science: the rise of a molecular understanding of life…an absorbing and, in places, thrilling book. The race to crack the genetic code is a story with considerable drama and it unfolds remarkably lucidly in Cobb's telling…On the whole Cobb tells his story beautifully and his book is a pleasure to read. Packed with fascinating detail, Life's Greatest Secret is a major accomplishment… Life's Greatest Secret highlights the power of the beautiful experiment in science…Big data provide important new tools to biology and medicine. But the larger lesson of Life's Greatest Secret is one that may be worth remembering. When scientists require definitive answers, not merely suggestive patterns, they require experiments that are decisive and, if all goes well, beautiful.”
New York Review of Books

“An absorbing, meticulous account of one of the greatest scientific stories of the 20th century.”
Guardian

Life's Greatest Secret is the logical sequel to Jim Watson's The Double Helix. While Watson and Crick deserve their plaudits for discovering the structure of DNA, that was only part of the story. Beginning to understand how that helix works—how its DNA code is turned into bodies and behaviors—took another 15 years of amazing work by an army of dedicated men and women. These are the unknown heroes of modern genetics, and their tale is the subject of Cobb's fascinating book. Every now and again I had to stop reading because the amazement overload was too great.”
—Jerry Coyne, Professor of Ecology and Evolution, The University of Chicago, and author of Why Evolution Is True

“Matthew Cobb is a respected scientist and historian, and he has combined both disciplines to spectacular effect in this wonderful book. A compelling, authoritative, and insightful account of how life works at the deepest level. Bloody brilliant!”
—Brian Cox, Professor of Physics, The University of Manchester and author of Why Does E=mc²?

L'autore:

Matthew Cobb is a professor of zoology at the University of Manchester, where he works on insects and on the history of science. He earned his BA in Psychology at the University of Sheffield, as well as his PhD there, in Psychology and Genetics. He is the translator of Michel Morange's History of Molecular Biology and the author of Generation (known as The Egg and Sperm Race, in the UK).

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Cobb, Matthew.
Editore: Basic Books. 1 Cloth(s) (2015)
ISBN 10: 0465062679 ISBN 13: 9780465062676
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Descrizione libro Basic Books. 1 Cloth(s), 2015. hard. Condizione libro: New. When Francis Crick and James Watson put forward their double-helix model of DNA structure in 1953, they set off an international race to uncover the secrets of the genetic code, which might reveal how a spiraling molecule gives rise to life. In this history—which features 16 pages of photographs—the author of Generation: The Seventeenth-Century Scientists Who Unraveled the Secrets of Sex, Life, and Growth chronicles how cooperation and competition between an assortment of eccentric characters—mathematicians, physicists, information theorists, and biologists—contributed to this revolutionary new science. Through a series of setbacks and triumphs, scientists arrived at an astonishing understanding of how matter forms, which Matthew Cobb suggests has important implications for future research."[This book is a] fine history of genetics. [A] gripping, insightful history, often from the mouths of the participants themselves."—Kirkus (starred review) 434. Codice libro della libreria 61944

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Descrizione libro BASIC BOOKS, 2012. Soft cover. Condizione libro: New. This is an advance reading, soft cover, uncorrected proof copy. These editions are issued prior to publication in small numbers and often are marked as first editions. FULL COLOR COVER.REFERENCES AND NOTES.NO INDEX. Codice libro della libreria 000454

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Descrizione libro Condizione libro: New. Depending on your location, this item may ship from the US or UK. Codice libro della libreria 97804650626760000000

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Descrizione libro BASIC BOOKS, 2015. HRD. Condizione libro: New. New Book.Shipped from US within 10 to 14 business days. Established seller since 2000. Codice libro della libreria IB-9780465062676

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Descrizione libro Basic Books. Hardcover. Condizione libro: New. 0465062679 Brand New Book. Ships from the United States. 30 Day Satisfaction Guarantee!. Codice libro della libreria 17591681

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Descrizione libro Hardcover. Condizione libro: New. Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life’s secrets.Life’s Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life’s) future.Life’s Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric charactersmathematicians, physicists, information theorists, and biologistswho contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or junk DNA" was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb’s telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who’d like to explore those questions for themselves. Codice libro della libreria 113626024

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Descrizione libro Basic Books, 2015. Hardcover. Condizione libro: New. Codice libro della libreria 0465062679

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Descrizione libro The Perseus Books Group, United States, 2015. Hardback. Condizione libro: New. 239 x 157 mm. Language: English . Brand New Book. Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life s secrets. Life s Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life s) future. Life s Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters--mathematicians, physicists, information theorists, and biologists--who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or junk DNA was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb s telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who d like to explore those questions for themselves. Codice libro della libreria AAS9780465062676

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Matthew Cobb
Editore: The Perseus Books Group, United States (2015)
ISBN 10: 0465062679 ISBN 13: 9780465062676
Nuovi Rilegato Quantità: 10
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(London, Regno Unito)
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Descrizione libro The Perseus Books Group, United States, 2015. Hardback. Condizione libro: New. 239 x 157 mm. Language: English . Brand New Book. Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life s secrets. Life s Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life s) future. Life s Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters--mathematicians, physicists, information theorists, and biologists--who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or junk DNA was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb s telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who d like to explore those questions for themselves. Codice libro della libreria AAS9780465062676

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