Process Scale Purification of Antibodies

ISBN 13: 9780470209622

Process Scale Purification of Antibodies

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9780470209622: Process Scale Purification of Antibodies

Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.

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From the Back Cover:

The cutting edge in antibody purification written by industry experts

Biopharmaceutical companies are under extreme pressure to develop robust and economical large-scale processes while consistently meeting regulatory standards for safety and purity. Traditional column chromatography dominates today's purification trains, and many of the productivity gains rely on upscaling such devices. This comes with a cost penalty, however, and further increases in upstream productivity make it a challenge to keep downstream processing manageable. Advances in purification technology are urgently needed to meet the requirements of the marketplace without sacrificing product quality.

Process Scale Purification of Antibodies offers scientists, researchers, and engineers an essential resource that focuses on current best practice in the manufacturing of antibody drugs, addresses problems in antibody purification, and offers suggestions to overcome current challenges and limitations. Written by experts in the field, the book examines old and new separation methods and includes an analysis of innovative trends that can help meet the economic pressures and escalating demand for antibody drugs.

Process Scale Purification of Antibodies:

  • Provides an overview of state-of-the-art methods in the downstream processing of therapeutic antibodies

  • Compiles information for the development of generic platform purification processes

  • Analyzes innovative technology trends such as weak partitioning chromatography, charged membranes, and new precipitation methods, as well as orthogonal and integrated strategies to improve throughput

  • Provides resources for solving technical challenges in antibody manufacturing

  • Discusses the economic drivers and benchmark values in antibody purification

About the Author:

Uwe Gottschalk, PhD, is Group Vice President, Purification Technologies, at Sartorius Stedim Biotech. Previously, he worked for Bayer Health Care, overseeing the purification of monoclonal antibodies and recombinant proteins produced in various expression systems. Dr. Gottschalk received a doctorate in chemistry from the University of Münster. He lectures at the University of Duisburg-Essen and the EPFL in Lausanne, Switzerland and has written extensively in the areas of biotechnology and somatic gene therapy.

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Descrizione libro John Wiley and Sons Ltd, United States, 2009. Hardback. Condizione libro: New. 1. Auflage. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification. Codice libro della libreria BZV9780470209622

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Editore: John Wiley and Sons Ltd, United States (2009)
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Descrizione libro John Wiley and Sons Ltd, United States, 2009. Hardback. Condizione libro: New. 1. Auflage. Language: English . Brand New Book. Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification. Codice libro della libreria BZV9780470209622

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Descrizione libro Wiley-Interscience, 2009. Hardcover. Condizione libro: Brand New. 1st edition. 352 pages. 9.25x6.00x1.00 inches. In Stock. Codice libro della libreria 0470209623

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