Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

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9780470581711: Clinical Trial Design: Bayesian and Frequentist Adaptive Methods

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods

There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics.

Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: *

Risk and benefit analysis for toxicity and efficacy trade-offs *

Bayesian predictive probability trial monitoring *

Bayesian adaptive randomization *

Late onset toxicity and response *

Dose finding in drug combination trials *

Targeted therapy designs

The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials.

Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

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Yin, Guosheng
ISBN 10: 0470581719 ISBN 13: 9780470581711
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Descrizione libro John Wiley and Sons Ltd, United States, 2012. Hardback. Condizione libro: New. New.. 236 x 156 mm. Language: English . Brand New Book. A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: * Risk and benefit analysis for toxicity and efficacy trade-offs * Bayesian predictive probability trial monitoring * Bayesian adaptive randomization * Late onset toxicity and response * Dose finding in drug combination trials * Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world s leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book s related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work. Codice libro della libreria AAH9780470581711

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Yin, Guosheng
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Descrizione libro John Wiley and Sons Ltd, United States, 2012. Hardback. Condizione libro: New. New.. 236 x 156 mm. Language: English . Brand New Book. A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: * Risk and benefit analysis for toxicity and efficacy trade-offs * Bayesian predictive probability trial monitoring * Bayesian adaptive randomization * Late onset toxicity and response * Dose finding in drug combination trials * Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world s leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book s related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work. Codice libro della libreria AAH9780470581711

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Descrizione libro Wileyand#8211;Blackwell, 2012. HRD. Condizione libro: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Codice libro della libreria FW-9780470581711

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Descrizione libro Wiley, 2012. Condizione libro: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. Codice libro della libreria ABE_book_new_0470581719

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