Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis with Nonlinear Mixed Effects Models - Rilegato

Owen, Joel S.; Fiedler-kelly, Jill

Rilegato

ISBN 10: 0470582294 ISBN 13: 9780470582299

Casa editrice: John Wiley & Sons Inc, 2014

Riassunto

This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis.
· Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects
· Provides examples of nonlinear modeling concepts and estimation basics with discussion on  the model building process and applications of empirical Bayesian estimates in the drug development environment
· Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control
· Has datasets, programming code, and practice exercises with solutions, available on a supplementary website

Su questo libro

Recensione:

"This book may make the "User Guide V experience" a story from the good old times for the next generation of pharmacometricians." (CPT: Pharmacometrics & Systems Pharmacology, 22 December 2014)

L'autore:

Joel S. Owen is Professor of Pharmaceutics at Union University, Jackson, Tennessee and President and Principal Scientist of Joel S. Owen, LLC. He has led workshops on NONMEM and PK/PD modeling concepts and applications and served as Director PK/PD at Cognigen Corporation in Buffalo, New York. He has published 16 articles in research publications.

Jill Fiedler-Kelly is Vice President and Chief Scientific Officer of Cognigen Corporation and Adjunct Associate Professor of Pharmaceutical Sciences at the University at Buffalo. She has been teaching workshops and graduate courses on population modeling for over 10 years and has published more than 20 articles and book chapters on pharmacokinetics and pharmacodynamics.

Su questa edizione

• Editore: John Wiley & Sons Inc
• Data di pubblicazione: 2014
• ISBN 10: 0470582294
• ISBN 13: 9780470582299
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 301