An integrated view of chiral drugs—from concept andsynthesisto pharmaceutical properties
Chirality greatly influences a drug's biological andpharmacological properties. In an effort to achieve morepredictable results from chiral drugs, the Food and DrugAdministration now requires that these medicines be as pure aspossible, which places great demands on drug synthesis,purification, analysis, and testing. To assist researchers inacquiring the essential knowledge to meet these rigid guidelines,Chiral Drugs focuses on three vital chiraltechnologies—asymmetric synthesis, biocatalytic process, andchiral resolution—to offer details on the basic concepts, keydevelopments, and recent trends in chiral drug discovery, alongwith:
The history of chiral drugs development and industrialapplications of chiral technologies
A section listing twenty-five approved or advanced-trial chiraldrugs that lists each drug name, chemical name and properties, arepresentative synthetic pathway, pharmacologicalcharacterizations, and references
An interdisciplinary approach combining synthetic organicchemistry, medicinal chemistry, and pharmacology
Nearly two-thirds of the drugs on today's market are chiraldrugs. Reducing and eliminating their negative characteristics isan ongoing and serious challenge for the pharmaceutical industry.With its well-balanced approach to covering each important aspectof chirality, Chiral Drugs champions important strategies fortipping the medical scale in a positive direction for theproduction of more effective—and safer—drugs.
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The book can be recommended to all those who are interested in this important and fast–growing field of research at the interface of chemistry, pharmacy, and medicine of the basic concepts behind modern biological psychiatric research and the recent history of the field. (ChemMedChem, 2012)
QI-DONG YOU, PHD, is the Dean and a professor of theSchool of Pharmacy at China Pharmaceutical University. He is anAssociate Editor of Progress in Pharmaceutical Sciences and serveson the Editorial Board of the International Journal of MedicinalChemistry and Acta Pharmaceutica Sinica. Dr. You is a coauthor ofover eighty publications, and an inventor or co-inventor of overtwenty patent applications and patents.
JIE-FEI CHENG, PHD, is the Director of Otsuka Shanghai ResearchInstitute, a fully owned subsidiary of Otsuka Pharmaceutical Co.,Ltd Japan. Formerly an associate professor at Shanghai Institute ofOrganic Chemistry, he has worked for over fifteen years in thepharmaceutical and biotech industries in the United States. Dr.Cheng is a coauthor of over fifty peer-reviewed publications, andan inventor or coinventor of over twenty patent applications andpatents.
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