Steroid Chemistry at a Glance - Rilegato

Lednicer, Daniel

Rilegato

ISBN 10: 0470660856 ISBN 13: 9780470660850

Casa editrice: John Wiley & Sons Inc, 2010

Riassunto

The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry".

Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include:

• history, isolation and structure determination of steroids
• steroid nomenclature and stereochemistry
• natural sources of steroids
• synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes
• steroids with a spirolactone at position 17
• steroids with hetrocyclic ring A
• compounds derived from cholesterol

Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.

Su questo libro

Recensione:

?This is another volume in the student-friendly Wiley series. The maxim `the best place to design a new drug is by modifying an old drug? makes steroids ideal, but chemists are forgiven for thinking that, even as excellent chiral building blocks, they are now dusty and old-fashioned. Long required to remedy this is a text dealing with classical steroid categorisation and biosynthetic aspects and also incorporating, with occasional mechanistic detail, extensive details of functional group modifications ? the inspiration for much classical chemistry.
Organising this work by structural class, the author generally achieves the right balance here. Classical `flat? representation of steroid structure is almost completely retained throughout, when perhaps more illustration of shape and stereochemistry could be instructive for visual rationalisation of functional group interconversions and structure? activity relationships. However, this is a relatively minor quibble. There are no references to deliver more detail on specific examples, but this does not detract from value. Those hunting for particular interconversions will have to jump around for examples, but it is hard to see a better way. There is a supporting special reactions index.
With frequent, if brief, integration with pharmacological activity, metabolism and clinical steroidal drugs, the result is a text appropriate for undergraduate organic chemists, but one which provides enough inspiration to seek wider biological details elsewhere. Postgraduates and medicinal chemists working specifically in steroid chemistry will gain an appraisal of specific areas before they begin more focused searching. With ample texts already focusing on steroid biology, this book fills a niche from a chemical angle.
Overall, this timely book is a valuable addition to the stable. It is applicable to both chemistry and pharmacy undergraduate curricula, unlocking part of the wealth of chemistry that is the legacy of the great 20th century steroid chemistry effort. One irritation, however, is the large number of errata reported, relating to incorrect structures, numbering, names and stereochemistry. This diminishes confidence a little and detracts from an otherwise excellent text in an area well placed for reappraisal by a modern chemical audience.?
- Chemistry World, October 2011

?This is another volume in the student-friendly Wiley series... With ample texts already focusing on steroid biology, this book fills a niche from a chemical angle. Overall, this timely book is a valuable addition to the stable.?
- Chemistry World, October 2011

L'autore:

Daniel Lednicer's career in both the private and public sectors has been devoted to the search for new therapeutic agents. He spent two decades at the bench as a chemist at the Upjohn Company. Following that, he served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute, Daniel Lednicer is the author of several books on drug synthesis and discovery, including seven volumes of the series "Organic Chemistry of Drug Synthesis".

Su questa edizione

• Editore: John Wiley & Sons Inc
• Data di pubblicazione: 2010
• ISBN 10: 0470660856
• ISBN 13: 9780470660850
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 144