What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knock: Behavioral Phenotyping of Transgenic and Knockout Mice - Rilegato

Crawley, Jacqueline N.

Rilegato

ISBN 10: 0471316393 ISBN 13: 9780471316398

Casa editrice: John Wiley & Sons, 2000

Riassunto

Transgenic and knockout mutations provide an important means for understanding gene function, as well as for developing therapies for genetic diseases. This engaging and informative book discusses the many advances in the field of transgenic technology that have enabled researchers to bring about various changes in the mouse genome. Equal emphasis is given to both the principles of transgenic and knockout methods and their applications. A clear and concise format provides researchers with a comprehensive review of the behavioral paradigms appropriate for analyzing mouse phenotypes. What's Wrong with My Mouse? explains the differences between transgenic knockout mice and their wild-type controls, while providing critical information about gene function and expression. This volume recognizes that newly identified genes can provide useful insights into brain functioning, including brain malfunctioning in disease states. Written by a world-renowned expert in the field, the material also covers: How to generate a transgenic or knockout mouse functions (open field, holeboard, rotarod, balance, grip, circadian activity, etc.) Sensory abilities (olfaction, vision, hearing, taste, touch, nociception) Reproductive behavior, social behavior, and emotional behavior Researchers in neuroscience, pharmacology, genetics, developmental biology, and cell biology will all find this book essential reading.

Su questo libro

Recensione:

"This is an excellent and timely book. I have been looking for an appropriate textbook for graduate students who are interested in using genetically engineered mice in various behavioral paradigms, and this is definitely the one to recommend." ––Noboru Hiroi, Ph.D., Albert Einstein College of Medicine

Su questa edizione

• Editore: John Wiley & Sons
• Data di pubblicazione: 2000
• ISBN 10: 0471316393
• ISBN 13: 9780471316398
• Rilegatura: Copertina rigida
• Numero di pagine: 352