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(4,2-disubstituted-thiazol-5-yl)amine Compounds As Pde7 Inhibitors: Patented by Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois and Pierre Ducrot on March 6, 2003. Abstract: A compound selected from those of formula (I), wherein R1a, R1b, R2, R3 are as defined in the description, and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE-7).
(Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones: Patented by Jerry L. Dallas, William J. Guilford, Sunil K. Koovakkat, Michael M. Morrissey and Kenneth J. Shaw on July 5, 1994. Abstract: This invention relates to novel (Z,Z), (Z,E) and (E,Z) olefin isomers of substituted benzylidene cycloketones and their pharmaceutically acceptable salts. The compounds of the invention are potent factor Xa inhibitors thereby acting as anticoagulants useful in a number of thrombotic disease states. Pharmaceutical compositions are proposed for the compounds.
1–phenylpyrazole Compounds and Medicinal Application Thereof: Patented by Seigo Ishibuchi, Hiroshi Morimoto, Atsushi Fukunari, Hiroyoshi Inoue and Yoichi Naka on October 22, 1997. Abstract: 1–Phenylpyrazole compounds represented by general formula (1) such as 5–amino–1–(3–cyano–4–isobutoxyphenyl)pyrazole–4–carboxylic acid, optical isomers thereof, and medicinally acceptable salts thereof. These compounds have a xanthine oxidase inhibitory effect and are useful as remedies for diseases such as hyperuricemia and gout.
1S to 1R Epimerizations of pyrethroid intermediates: Patented by Ronald E. Montgomery and Leland A. Smeltz on October 5, 1997. Abstract: This invention relates to a process for preparing certain isomers of 2,2-dimethyl-3-(2,2-disubstitutedvinyl)cyclopropanecarboxylic acid or derivatives thereof. More specifically it relates to the epimerization of the 1S cyclopropanecarboxylic acid and its derivatives into the corresponding 1R isomers.
2,1,3-Benzothia(oxa)diazole Derivatives Having an Endothelin Receptor Antagonistic Effect: Patented by Dieter Dorsch, Mathias Osswald, Werner Mederski, Claudia Wilm, Claus Schmitges, Maria Christadler and Soheila Anzali on February 20, 1997. Abstract: The invention concerns compounds of formula (I), in which R is (i), (ii) or (iii); n is 0, 1 or 2; X means O or S; and R 1 , R 2 , R 3 and R 4 have different meanings, or a cyclized tautomeric shape. The invention also concerns the (E) isomers and salts of these compounds which display endothelin receptor antagonistic properties.
2,4-BIS(2-HYDROXYHEXAFLUORO-2-PROPYL)FLUOROBENZENE AND METHOD OF PREPARING SAME: Patented by Masamichi Maruta and Takayuki Nishimiya on June 1, 1989. Abstract: By reacting fluorobenzene with hexafluoroacetone in the pressure of a Lewis acid catalyst, e.g. aluminum chloride, a novel compound 2,4-bis(2-hydroxyhexafluoro-2-propyl)fluorobenzene is formed at high yield with little formation of isomers. The novel compound is useful as a cross-linking agent for some polymers and also as a material of some polymers.
2-[1h]-quinolone and 2-[1h]-Quinoxalone Inhibitors of Factor Xa: Patented by Bing-Yan Zhu and Robert Scarborough on February 1, 2001. Abstract: Novel compounds of general formula I, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa is described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
2-acyl Indol Derivatives and Their Use As Anti-Tumour Agents: Patented by Thomas Beckers, Silke Baasner, Thomas Klenner, Siavosh Mahboobi, Herwig Pongratz, Markus Frieser, Harald Hufsky, Jörg Hockemeyer, Heinz-Herbert Fiebig, Angelika Burger and Frank-D. Böhmer on April 27, 2001. Abstract: The invention relates to novel indol and heteroindol derivatives of the general formula (I), to their tautomers, stereo isomers, their mixtures and their salts, to the production thereof and to the use of indol derivatives of the general formula (I) as medicaments.
2-amino naphthyridine derivative, its preparation and its use: Patented by Marie-Therese David-Comte and Gerard Roussel on January 2, 1994. Abstract: The present invention relates to a novel 2-aminonaphthyridine compounds that are useful in preparing a 2-isoindolinyl napthyridine compound that exhibits remarkable anxiolytic, hypnotic, anticonvulsant, antiepileptic and muscle-relaxant properties. The invention is also directed to the optical isomers of the 2-amino napthyridine compounds and salts thereof, their preparation and the use of the 2-amino napthyridine compounds for preparing the 2-isoindolinyl napthyridine compound.
2–arylethyl–(piperidin–4–ylmethyl)amine Derivatives As Muscarinic Receptor Antagonists: Patented by Joan M. Caroon, Robin D. Clark, Michael P. Dillon, Ralph N. Harris Iii, Sharathchandra S. Hegde, Clara J. Lin Jen, Hans Maag and David B. Repke on February 19, 1999. Abstract: This invention relates to muscarinic receptor antagonists compounds of formula (I) and to their pharmaceutically acceptable salts, individual isomers or to a racemic or non–racemic mixture; to pharmaceutical compositions containing them, and to methods for their use as therapeutic agents.
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Descrizione libro ICON Group International, Inc., 2009. Paperback. Condizione libro: Brand New. 254 pages. 9.00x7.00x0.57 inches. This item is printed on demand. Codice libro della libreria zk054679257X