The Biology of Cancer is a textbook for undergraduate and graduate biology students as well as medical students studying the molecular and cellular bases of cancer. The book presents the principles of cancer biology in an organized, cogent, and in-depth manner. The clarity of writing and the lucid full-color art program make the book accessible and engaging. The information unfolds through the presentation of key experiments which give readers a sense of discovery and provides insights into the conceptual foundation underlying modern cancer biology.
The Biology of Cancer synthesizes the findings of three decades of recent cancer research and proposes a conceptual framework from which to teach about these discoveries. It provides the necessary structure, organization, and content for a course on cancer biology for advanced undergraduates and beginning doctoral students. The book is comprehensive and offers many pedagogical features to assist teaching and learning. The book includes many recent and topical references, and is intended to empower the student to move directly into the primary research literature.
The text is up-to-date and provides current information on topics such as tumor stem cells and recently introduced chemotherapeutics. State-of-the-art techniques are discussed throughout. Modern biomedical research is explored, helping readers to hone their analytical abilities and to assimilate and think clearly about complex biological processes. The Biology of Cancer provides insights into many aspects of immunology, developmental biology, and neurobiology.
The exceptional full-color art program contains many images published for the first time. The book is extensively illustrated with schematic drawings, micrographs, computer-generated models and graphs. The pieces were chosen to support and clarify the concepts, as well as to supply additional interest.
Besides its value as a textbook, The Biology of Cancer will be a useful reference for individuals working in biomedical laboratories, and for clinical professionals.
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This is an impressively thoughtful, beautifully balanced analysis of where we stand today in the critical attempt to understand, and thereby defeat cancer as a scourge on humanity. Not only is it the perfect text for a serious course on cancer biology, it should be read by every cancer researcher - Bruce Alberts, University of California, San Francisco, USA
The Biology of Cancer is no doubt the definitive statement on its topic today. -Science, 11 August 2006: Vol. 313. no. 5788
There is no comparable text in cancer biology and no single book that is so current and informative. -Nature, November 30, 2006, Vol 444
'The Biology of Cancer, written by the distinguished American cancer biologist Robert Weinberg, is by far the most extensive of these new works and, as the product of a single author, is a remarkable achievement. The book is beautifully illustrated in full colour and well supplied with key review articles. It is extremely well written in language that should be accessible to the non-expert. Overall, this is a remarkable achievement that is by far the most comprehensive coverage of this field available.' - The Times Higher Education Supplement, February 23rd 2007
"The breadth of the topics covered, the clear writing style, the logical organization and the beautiful figures make The Biology of Cancer a classic text for any biologist interested in cancer...An additional strength of the book is the multimedia CD...¦Thus, The Biology of Cancer is not only a great read but also an outstanding learning tool."-Nature Cell Biology (November 2007) vol. 9, no. 11About the Author:
Dr. Robert A. Weinberg is a founding member of the Whitehead Institute for Biomedical Research and the Daniel K. Ludwig Professor for Cancer Research at the Massachusetts Institute of Technology (MIT). He is an internationally recognized authority on the genetic basis of human cancer.
Dr. Weinberg and his colleagues isolated the first human cancer-causing gene, the ras oncogene, and the first known tumor suppressor gene, Rb, the retinoblastoma gene. The principal goal of his research program is to determine how oncogenes, their normal counterparts (proto-oncogenes), and tumor suppressor genes fit together in the complex circuitry that controls cell growth. More recently, his group has succeeded in creating the first genetically defined human cancer cells. He is particularly interested in applying this knowledge to improve the diagnosis and treatment of breast cancer.
Dr. Weinberg is the author or editor of five books and more than 325 articles. His three most recent books, intended for a lay audience, are "One Renegade Cell", "Racing to the Beginning of the Road: The Search for the Origin of Cancer" and "Genes and the Biology of Cancer," co-authored with Dr. Harold E. Varmus, former Director of the National Institutes of Health. He is an elected Member of the U.S. National Academy of Sciences and Fellow of the American Academy of Arts and Sciences.
Among Dr. Weinberg's many honors and awards are the Discover Magazine 1982 Scientist of the Year, the National Academy of Sciences/U.S. Steel Foundation Award in Molecular Biology, the Sloan Prize of the General Motors Cancer Research Foundation, the Bristol-Myers Award for Distinguished Achievement in Cancer Research, the Harvey Prize from the American Society for Technion Israel Institute of Technology, the Gairdner Foundation International Award, the Keio Medical Foundation Prize, the 1997 National Medal of Science, the City of Medicine Award and the 2004 Wolf Foundation Prize and the Prince of Asturias Science Prize. He has served on scientific advisory boards for the Institute of Molecular Pathology in Vienna, Austria, the Weizmann Institute in Rehovot, Israel, and the Massachusetts General Hospital in Boston.
Born in Pittsburgh in 1942, Dr. Weinberg received his BS (1964) and PhD (1969) degrees in Biology from MIT. He did postdoctoral research at the Weizmann Institute and the Salk Institute in La Jolla, California, and then returned to MIT in 1972. In 1982, he was appointed Professor of Biology at MIT and also became one of the five original Members of the Whitehead Institute. He has been an American Cancer Society Research Professor at Whitehead and MIT since 1985.
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Descrizione libro Paperback. Condizione libro: BRAND NEW. BRAND NEW. Fast Shipping. Prompt Customer Service. Satisfaction guaranteed. Codice libro della libreria 0815340761BNA
Descrizione libro Garland Science, 2006. Paperback. Condizione libro: New. 1 Pap/Cdr/. Codice libro della libreria DADAX0815340761
Descrizione libro Garland Science, 2006. Condizione libro: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: PrefaceChapter 1 The Biology and Genetics of Cells and Organisms1.1 Mendel establishes the basic rules of genetics1.2 Mendelian genetics helps to explain Darwinian evolution1.3 Mendelian genetics governs how both genes and chromosomes behave1.4 Chromosomes are altered in most types of cancer cells1.5 Mutations causing cancer occur in both the germ-line and the soma1.6 Genotype embodied in DNA sequences creates phenotype through proteins1.7 Gene expression patterns also control phenotype1.8 Transcription factors control gene expression1.9 Metazoa are formed from components conserved over vast evolutionary time periods1.10 Gene cloning techniques revolutionized the study of normal and malignant cellsChapter 2 The Nature of Cancer2.1 Tumors are complex tissues2.2 Tumors arise from many specialized cell types throughout the body2.3 Some types of tumors do not fit into the major classifications2.4 Cancers seem to develop progressively2.5 Tumors are monoclonal growths2.6 Cancers occur with vastly different frequencies in different human populations2.7 The risks of cancers often seem to be increased by assignable influences including lifestyle2.8 Specific chemical agents can induce cancer2.9 Both physical and chemical carcinogens act as mutagens2.10 Mutagens may be responsible for some human cancers2.11 Synopsis and prospectsEssential ConceptsAdditional ReadingChapter 3 Tumor viruses3.1 Peyton Rous discovers a chicken sarcoma virus3.2 Rous sarcoma virus is discovered to transform infected cells in culture3.3 The continued presence of RSV is needed to maintain transformation3.4 Viruses containing DNA molecules are also able to induce cancer3.5 Tumor viruses induce multiple changes in cell phenotype including acquisition of tumorigenicity3.6 Tumor virus genomes persist in virus-transformed cells by becoming part of host cell DNA3.7 Retroviral genomes become integrated into the chromosomes of infected cells3.8 A version of the src gene carried by RSV is also present in uninfected cells3.9 RSV exploits a kidnapped cellular gene to transform cells3.10 The vertebrate genome carries a large group of proto-oncogenes3.11 Slowly transforming retroviruses activate proto-oncogenes by inserting their genomes adjacent to these cellular genes3.12 Some retroviruses naturally carry oncogenes3.13 Synopsis and prospectsEssential ConceptsAdditional ReadingChapter 4 Cellular oncogenes4.1 Can cancers be triggered by the activation of endogenous retroviruses?4.2 Transfection of DNA provides a strategy for detecting nonviral oncogenes4.3 Oncogenes discovered in human tumor cell lines are related to those carried by transforming retroviruses4.4 Proto-oncogenes can be activated by genetic changes affecting either protein expression or structure4.5 Variations on a theme: the myc oncogene can arise via at least three additional distinct mechanisms4.6 A diverse array of structural changes in proteins can also lead to oncogene activation4.7 Synopsis and prospectsEssential ConceptsAdditional ReadingChapter 5 Growth factors and their receptors5.1 Normal metazoan cells control each other''s lives5.2 The Src protein functions as a tyrosine kinase5.3 The EGF receptor functions as a tyrosine kinase5.4 An altered growth factor receptor can function as an oncoprotein5.5 A growth factor gene can become an oncogene: the case of sis5.6. Transphosphorylation underlies the operations of receptor tyrosine kinases5.7 Yet other types of receptors enable mammalian cells to communicate with their environment5.8 Integrin receptors sense association between the cell and the extracellular matrix5.9 The Ras protein, an apparent component of the downstream signaling cascade, functions as a G protein5.10 Synopsis and ProspectsEssential ConceptsAdditional ReadingChapter 6 Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer6.1 A signaling pathway reaches from the cell surface into the nucleus6.2 T. Codice libro della libreria ABE_book_new_0815340761
Descrizione libro Condizione libro: Brand New. Book Condition: Brand New. Codice libro della libreria 97808153407681.0
Descrizione libro Garland Science, 2006. Paperback. Condizione libro: New. book. Codice libro della libreria 0815340761
Descrizione libro Garland Science, 2006. Paperback. Condizione libro: New. Codice libro della libreria P110815340761
Descrizione libro Taylor & Francis Group. Condizione libro: New. pp. 864 This item is printed on demand. Codice libro della libreria 8366170