Articoli correlati a Antisense Drug Technology: Principles: Strategies,...

Antisense Drug Technology: Principles: Strategies, and Applications - Rilegato

 
9780824705664: Antisense Drug Technology: Principles: Strategies, and Applications
Vedi tutte le copie di questo ISBN:
 
 
This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds.
Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes!

Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses
  • novel formulations of antisense drugs
  • practical methods to design effective isotype selective inhibitors
  • molecular mechanisms of antisense drugs
  • mRNA as a current biological template
  • modern postreceptor binding mechanisms
  • and more!
    With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.

  • Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

    Contenuti:
    Basic Principles of Antisense Technology
    Stanley T. Crooke
    Medicinal Chemistry of Antisense Oligonucleotides
    P. Dan Cook
    Analytical Methods for Antisense Drugs
    Janet M. Leeds and Lendell L. Cummins
    A Role for Antisense Technology in the Discovery of Highly Specific and Versatile Signal Transduction Inhibitors
    Brett P. Monia, Erich Koller, and William A. Gaarde
    Methods of Selecting Sites in RNA for Antisense Targeting
    Susan M. Freier

    Properties of Phosphorothioate Oligonucleotides

    Pharmacokinetic Properties in Animals
    Richard S. Geary, Rosie Z. Yu, Janet M. Leeds, Michael V. Templin, Tanya A. Watanabe, Scott P. Henry, and Arthur A. Levin
    Suborgan Pharmacokinetics
    Rosanne M. Crooke and Mark J. Graham
    Pharmacokinetic Properties in Humans
    Rosie Z. Yu, Steven L. Schoenfeld, Richard S. Geary, Tanya A. Watanabe, and Arthur A. Levin
    Toxicity of Antisense Oligonucleotides
    Arthur A. Levin, Scott P. Henry, David Monteith, and Michael V. Templin
    Clinical Safety of Phosphorothioate Oligodeoxynucleotides
    F. Andrew Dorr, Josephine M. Glover, and T. Jesse Kwoh
    General Pharmacology of Phosphorothioate Oligodeoxynucleotides
    C. Frank Bennett

    Properties of Advanced Novel Clinical Classes of Oligonucleotides

    Pharmacology of 2´-0-(2-Methoxy)ethyl Modified Antisense Oligonucleotides
    Nicholas M. Dean, Madeline Butler, Brett P. Monia, and Muthiah Manoharan
    Locked Nucleic Acid
    Jesper Wengel
    Antisense Properties of Peptide Nucleic Acid (PNA)
    Uffe Koppelhus and Peter J. Nielsen
    Phosphorodiamidate Morpholino Oligomers
    Patrick Iversen
    Oligonucleotide Conjugates in Antisense Technology
    Muthiah Manoharan
    Immune Stimulation by Oligonucleotides
    Arthur M. Krieg
    Pre-mRNA Splicing as a Target for Antisense Oligonucleotides
    Ryszard Kole and Danielle Mercatante
    Application of Antisense Oligonucleotides to the Study of CNS Protein Function
    Siew Peng Ho
    Antisense Approach to Isoform-Specific Blockade of Acetylcholinesterase
    Hermona E. Soreq and Shlomo Seidman
    Serine/Threonine Protein Phosphates
    Richard E. Honkanen
    Pharmacological Activities of Antisense Drugs: Inflammatory Diseases
    James G. Karras, Kathleen J. Myers, and Brenda F. Baker
    Respirable Antisense Oligonucleotides (RASONs)
    Jonathan W. Nyce
    Combined Antisense Therapy and Chemotherapy in Animal Models
    Dan Mercola
    Antisense Oligodesoxynucleotide Strategies in Renal and Cardiovascular Disease
    Hermann Haller, Christian Maasch, Duska Dragun, Maren Wellner, and Friedrich C. Luft
    The Development of Antisense Oligonucleotides as Antivirals
    Lisa R. Grillone
    Clinical Activities in Patients with Solid Tumors or Lymphoma
    Jon T. Holmlund
    Nucleic Acid Therapeutics for the Treatment of Human Leukemia
    Alan M. Gewirtz
    ISIS 2302, an Antisense Inhibitor of Intercellular Adhesion Molecule 1 (ICAM-1)
    William R. Shanahan, Jr.
    New Routes and Novel Formulations for Delivery of Antisense Oligonucleotides
    Gregory E. Hardee, Susan P. Weinbach, and Lloyd G. Tillman
    DNA-Binding Molecules
    Roland W. Bürli and Heinz E. Moser
    Targeted Genome Modification via Triple Helix Formation
    Margaret A. Macris and Peter M. Glazer
    Intracellular Ribozyme Applications
    John J. Rossi

    Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

    • EditoreCRC Press
    • Data di pubblicazione2001
    • ISBN 10 0824705661
    • ISBN 13 9780824705664
    • RilegaturaCopertina rigida
    • Numero edizione1
    • Numero di pagine948
    • RedattoreCrooke Stanley T.
    Compra usato
    Befriedigend/Good: Durchschnittlich... Scopri di più su questo articolo

    Spese di spedizione: EUR 4,00
    Da: Germania a: Italia

    Destinazione, tempi e costi

    Aggiungere al carrello

    Altre edizioni note dello stesso titolo

    9780849387968: Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition

    Edizione in evidenza

    ISBN 10:  ISBN 13:  9780849387968
    Casa editrice: CRC Press, 2007
    Rilegato

    I migliori risultati di ricerca su AbeBooks

    Foto dell'editore

    Stanley T. Crooke
    Editore: CRC Press (2001)
    ISBN 10: 0824705661 ISBN 13: 9780824705664
    Antico o usato Rilegato Quantità: 1
    Da:
    medimops
    (Berlin, Germania)
    Valutazione libreria

    Descrizione libro Befriedigend/Good: Durchschnittlich erhaltenes Buch bzw. Schutzumschlag mit Gebrauchsspuren, aber vollständigen Seiten. / Describes the average WORN book or dust jacket that has all the pages present. Codice articolo M00824705661-G

    Informazioni sul venditore | Contatta il venditore

    Compra usato
    EUR 189,05
    Convertire valuta

    Aggiungere al carrello

    Spese di spedizione: EUR 4,00
    Da: Germania a: Italia
    Destinazione, tempi e costi
    Foto dell'editore

    Editore: CRC Press (2001)
    ISBN 10: 0824705661 ISBN 13: 9780824705664
    Antico o usato Rilegato Quantità: 1
    Da:
    Mispah books
    (Redhill, SURRE, Regno Unito)
    Valutazione libreria

    Descrizione libro Hardcover. Condizione: Like New. Like New. book. Codice articolo ERICA81908247056613

    Informazioni sul venditore | Contatta il venditore

    Compra usato
    EUR 453,00
    Convertire valuta

    Aggiungere al carrello

    Spese di spedizione: EUR 29,24
    Da: Regno Unito a: Italia
    Destinazione, tempi e costi