Contenuti:
Analytical method considerations for toxicokinetic studies, D. Scott Wright; pharmacokinetic principles - linear and nonlinear, Peter G. Welling; biotransformation of xenobiotics to chemically reactive metabolites, Neal Castagnoli, Jr., and Kay P. Castagnoli; role of toxicokinetics in dose selection for carcinogenicity studies, Mitchell N. Cayen and Hugh E. Black; toxicokinetic study design and integrated programmes, Eva Halperin-Walega, et al; role of toxicokinetics in toxicity testing, L.F. Chasseaud; relation between toxicity and kinetics and models of renal disease, Norberto Perico and Silvio Garattini; route of administration and toxicity, Lloyd Dethloff; genetic variations in humans and toxicokinetics, Bert N. La Du, Jr.; comparative histokinetic and xenodynamic considerations in toxicity, Michael J. Iatropoulos; toxicokinetics of anticancer compounds, Lloyd R. Whitfield and David G. Pegg; toxicokinetics of chemical carcinogens, Anthony J. Streeter; application of toxicokinetic principles in the developoment of antiatherosclerotic compounds, Robert L. Susick and Thomas Woolf; toxicokinetics of drugs acting on the central nervous system, D. Scott Wright, et al; toxicokinetics of antibacterial agents - pre-clinical perspective, Robert D. Smyth and Robert J. Smyth; perspective and future directions of toxicokinetics in drug development, Felix A. de la Iglesia.
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