Controlled Drug Delivery: Challenges and Strategies - Rilegato

9780841234185: Controlled Drug Delivery: Challenges and Strategies

Rilegato

ISBN 10: 0841234183 ISBN 13: 9780841234185

Casa editrice: American Chemical Society, 1999

This volume discusses the challenges of creating controlled release dosage forms that will deliver new therapeutic agents based on high-molecular-weight molecules. It examines strategies for delivering drugs through resistant biological barriers and surveys a variety of topics, including drug targeting, self-regulated drug delivery, protein drug delivery, biosensors, cell and tissue engineering, new biomaterials, modeling methods, pharmacokinetics, and U.S. federal regulations.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Contenuti:

1Joseph R. Robinson: Controlled Drug Delivery: Past, Present, and Future
INTRACELLULAR DELIVERY AND TARGETING
2: Philip S. Low and Christopher P. Leamon: Intracellular Delivery of Peptides and Proteins
3: Joel M. Kupfer: DNA Delivery Vectors for Somatic Cell Gene Therapy
4: Kazunori Kataoka: Targetable Polymeric Drugs
5: P. D. Scholes, A. G. A. Coombes, M. C. Davies, L. Illum, and S. S. Davis: Particle Engineering of Biodegradable Colloids for Site-Specific Drug Delivery
6: Randall J. Mrsny: Site-Specific Drug Delivery in the Gastrointestinal Tract
SELF-REGULATED DRUG DELIVERY
7: Jorge Heller: Feedback-Controlled Drug Delivery
8: You Han Bae: Stimuli-Sensitive Drug Delivery
9: A. Adam Sharkawy, Michael R. Neuman, and William M. Reichert: Sensocompatibility: Design Considerations for Biosensor-Based Drug Delivery Systems
DELIVERY OF PEPTIDE AND PROTEIN DRUGS
10: Steven L. Nail: Formulation of Proteins and Peptides
11: Christian Sch'sneich, Michael J. Hageman, and Ronald T. Borchardt: Stability of Peptides and Proteins
12: Steven P. Schwendeman, Henry R. Costantino, Rajesh K. Gupta, and Robert Langer: Peptide, Protein, and Vaccine Delivery from Implantable Polymeric Systems
13: Terry L. Bowersock and Harm HogenEsch: Oral Immunization Using Microparticles
14: Thomas H. Ferguson: Peptide and Protein Delivery for Animal Health Applications
TISSUE ENGINEERING AND GENE THERAPY
15: Julia E. Babensee and Michael V. Sefton: Protein Delivery by Microencapsulated Cells
16: D. J. Mooney and J. A. Rowley: Tissue Engineering: Integrating Cells and Materials To Create Functional Tissue Replacements
17: Richard L. Eckert, Daniel J. Smith, and Irwin A. Schafer: Drug Delivery Using Genetically Engineered Cell Implants
18: Akira Wada, Takashi Shimayama, Serguei V. Amontov, Masaya Orita, Tetsuhiko Koguma, Jun Ohkawa, and Kazunari Taira: Ribozymes as Antiviral Agents
NEW BIOMATERIALS FOR DRUG DELIVERY
19: Kenneth James and Joachim Kohn: Pseudo-Poly(amino acid)s: Examples for Synthetic Materials Derived from Natural Metabolites
20: Dan W. Urry, Cynthia M. Harris, Chi Xiang Luan, Chi-Hao Luan,: Transductional Protein-Based Polymers as New Controlled-Release Vehicles
21: Joseph Cappello: Synthetically Designed Protein Polymer Biomaterials
22: Jun Liao and Raphael M. Ottenbrite: Biological Effects of Polymeric Drugs
23: Kam W. Leong, Zhong Zhao, and Basil I. Dahiyat: New Biodegradable Polymers for Medical Applications: Elastomeric Poly(phosphoester-urethane)s
24: Allan S. Hoffman: "Intelligent" Polymers
MODELING OF CONTROLLED DRUG DELIVERY
25: Ronald A. Siegel: Modeling of Self-Regulating Oscillatory Drug Delivery
26: Balaji Narasimhan and Nicholas A. Peppas: Modeling Studies of Future Controlled-Release Devices
27: D. Robert Lu: Computer Dynamics Simulation of Controlled Release
REGULATORY ISSUES
28: Garnet E. Peck: Food and Drug Regulations for Controlled-Release Dosage Forms
29: Philip R. Mayer: Pharmacodynamic and Pharmacokinetic/ Considerations in Controlled Drug Delivery