Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition

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9780849392788: Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition

To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. The book focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest.

New to the Second Edition

  • Updated sections on anesthesia and perioperative care, including practical information for more complex models
  • Expansion of anatomic and physiologic details
  • Additional detail in the endoscopy section
  • Chapters on toxicology and radiobiology
  • Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images
  • More tables of normal values on the most commonly used minipigs and domestic breeds

    Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedical research.
  • Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

    Contenuti:

    BIOLOGY, HANDLING, HUSBANDRY, AND ANATOMY
    Introduction
    Breed Selection
    Biology
    Taxonomy and Nomenclature
    Reproduction
    Growth and Development
    Nutrition
    Hematology
    Behavior
    Husbandry
    Disease Prevention
    Restraint and Handling
    Administration of Medications and Injections
    General Anatomy
    Model Selection
    References

    ANESTHESIA, ANALGESIA, AND PERIOPERATIVE CARE
    Introduction
    Anesthetic Induction and Animal Prep Room Activities
    Endotracheal Intubation
    Special Perioperative Considerations
    Malignant Hyperthermia
    Paralytic Agents
    Postoperative Monitoring
    Preanesthetic Agents
    Injectable Anesthetic Agents
    Inhalant Anesthetics
    Cardiopulmonary Bypass (CPB)
    Regional Low-Flow Perfusion and Neural Protection
    Analgesics
    Commonly Recommended Protocols
    General Physiological Effects of Anesthetics
    Euthanasia
    References

    WOUND CLOSURE AND INTEGUMENT
    General Principles and Surgical Preparation
    Suture Selection for Wound Closure
    Skin Flaps and Grafts
    Wound-Healing Models
    References

    GASTROINTESTINAL PROCEDURES
    Surgical Anatomy
    General Principles of Abdominal Surgery
    Postoperative Care
    Gastronomy and Gastrostomy Techniques
    Pyloroplasty
    Enterotomy and Intestinal Fistulation
    Intestinal Infusion Catheter Implantation
    Intestinal Anastomosis
    Intestinal Diversion or Intestinal Bypass
    Colonic Anastomosis and Fistulation
    Total Colectomy
    Rectal Prolapse
    Intestinal and Multivisceral Transplantation
    Vagotomy
    Intraperitoneal Sepsis, Septic Shock, and Hemorrhagic Shock
    References

    LIVER AND BILIARY SYSTEM
    Surgical Anatomy and General Principles of Surgery
    Cholecystectomy
    Cannulation or Constriction of the Common Bile Duct
    Partial Hepatectomy, Liver Biopsy, and Intrahepatic Cannulation
    Liver Transplantation
    Hepatic Xenoperfusion
    References

    PANCREAS AND SPLEEN
    Surgical Anatomy and General Principles of Surgery
    Pancreatectomy, Islet Cell Ablation, and Diabetes
    Segmental Pancreatectomy, Pancreatic Transplant, and Islet Cell Isolation
    Pancreatic Duct Ablation, Cannulation, and Pancreatitis
    Splenectomy, Splenic Vascular Catheterization, and Splenic Transplantation
    References

    URINARY SYSTEM AND ADRENAL GLANDS
    General Principles of Surgery and Surgical Anatomy
    Nephrectomy
    Partial Nephrectomy and Intrarenal Surgery
    Renal Transplant
    Cystotomy and Ureteral Diversion
    Urinary Tract Obstruction, Reflux Nephropathy, and Hydronephrosis
    Perineal Urethrostomy and Urinary Diversion
    Preputial Diverticulum Ablation
    Adrenalectomy
    References

    REPRODUCTIVE SYSTEM
    General Principles of Surgery
    Castration (Orchiectomy) and Vasectomy
    Ovariohysterectomy, Hysterectomy, Ovariectomy, or Tubal Ligation
    Cesarean Section (C-Section)
    Fetal Surgery and Fetal Catheterization
    Prolapse of the Reproductive Tract
    Endometriosis
    Pelvic Adhesions
    Artifical Insemination and Embryo Transfer
    Mammectomy
    References

    CARDIOTHORACIC AND VASCULAR SURGERY/CHRONIC INTRAVASCULAR CATHETERIZATION
    General Principles of Cardiothoracic Surgery and Surgical Anatomy
    Pulmonary System
    Cardiovascular System
    Miscellaneous Thoracic Procedures

    HEAD AND NECK SURGERY/CENTRAL NERVOUS SYSTEM
    General Principles of Surgery and Surgical Anatomy
    Dental Procedures and Tusk Trimming
    Maxillofacial and Craniotomy Procedures
    Ocular Surgery
    Pharyngostomy Tubes
    Thyroidectomy
    Parathyroidectomy
    Hypophysectomy
    Spinal Cord Ischemia and Hemorrhage
    Stroke Models
    Cerebrospinal Fluid (CSF) Collection and Epidural Injection

    MUSCULOSKELETAL SYSTEM AND ORTHOPEDIC PROCEDURES
    General Principles of Surgery and Surgical Anatomy
    Amputation of a Digit and Hoof Trimming
    Tendon and Ligament Repair
    Tail Amputation
    Hernia Repair
    Surgical Approaches to Bones and Joints
    Bone Marrow Aspiration

    CARDIOVASCULAR CATHETERIZATION, ELECTROPHYSIOLOGY, AND IMAGING LABORATORY PROCEDURES
    Introduction
    Peripheral Vascular Access for Cardiovascular Catheters
    Anesthetics and Adjunct Drugs
    Hemodynamics
    Angioplasty Balloon Techniques, Intravascular Device Implantations, and Restenosis
    Atherosclerosis
    Electrophysiology and Electrocardiography (ECG) and Telemetry
    Pacemark Implantation and Endocardial Pacemaker Leads
    Conduction System Ablation
    Angiography
    Echocardiography

    ENDOSCOPIC, LAPAROSCOPIC, AND MINIMALLY INVASIVE SURGERY by M.M. Swindle and R.H. Hawes
    Introduction
    General Considerations
    Anatomic Considerations for Flexible Endoscopic Research
    Performing Endoscopy
    Endoscopic Retrograde Cholangiopancreatography Research (ERCP)
    Endoscopic Hemostasis (Gastrointestinal Bleeding)
    Colonoscopy
    Larynoscopy and Bronchoscopy
    Training in Flexible Endoscopy
    Laparoscopic, Celioscopic, and Thoracoscopic Surgery
    Postoperative Care for Laparoscopic and Endoscopic Procedures
    Natural Orifice Translumenal Endoscopic Surgery (NOTES)
    Surgical Robotics

    XENOTRANSPLANTATION AND TRANSGENIC TECHNOLOGIES
    Introduction
    Ethical Considerations
    Immunologic and Physiological Considerations
    Strategies for Development of Transgenic Animals
    Regulatory Guidelines
    Public Health Considerations
    Management and Husbandry Strategies
    Other Considerations

    TOXICOLOGY by Ove Svendsen
    Introduction
    Domestic Pigs and Minipigs
    Strains of Minipigs
    Pharmacokinetics and Metabolism
    Repeat Dose Toxicology
    Reproductive Toxicology
    Juvenile Studies
    Regulatory Acceptance
    Conclusions for Toxicological Models
    Acknowledgments

    RADIOBIOLOGY

    IMAGING TECHNIQUES: CT, MRI, AND PET SCANNING by Aage Kristian Olsen, Dora Zeidler, Kasper Pedersen, Michael Sorensen, Svend Borup Jensen, and Ole Lajord Munk
    Scanners
    Anesthesia
    Surgery
    Monitoring
    Scanning Procedures
    Technical Information for DVD Images

    OSSABAW ISLAND MINIATURE SWINE: CARDIOMETABOLIC SYNDROME ASSESSMENT by Michael Sturek, Mouhamad Alloosh, James Wenzel, James P. Byrd, Jason M. Edwards, Pamela G. Lloyd, Johnathan D. Tune, Keith L. March, Michael A. Miller, Eric A. Mokelke, and I. Lehr Brisbin, Jr.
    Introduction
    Characterization of the Model
    Summary and Conclusions
    Acknowledgments

    APPENDIX
    INDEX

    References appear at the end of each chapter.

    Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

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