When first conceived, not only was the aim of Protocols for Oligo nucleotides and Analogs to provide wide coverage of the ohgonuc- otide chemistry field for readers who are well versed within the field, but also to give investigators just entering into the field a new perspective. The very first book on this topic was edited and published by Michael Gait in 1984, in whose laboratory I encountered the newer aspects of oligonucleotide chemistry. Since then, oligonucleotide research has developed to such an extent that its uses extend far beyond basic studies, and now find wide application throughout clinical science as well. Until recently, the major application of oligonucleotides has been in the area of DNA-based diagnostic and "antisense oligonucleotid- based therapeutic approaches. However, oligonucleotides are now also being used as therapeutic agents and are thus frequently found in clinical trials in humans. Synthesis of unmodified oligonucleotides using automated synthe sizers has become a common practice in numerous laboratories. How ever, improvements on the existing techniques and the introduction of ever newer methods for oligonucleotide synthesis is constantly driving ahead in the leading research laboratories. And several new oligonucle otide analogs have been synthesized and studied for their individual prop erties in recent years. The present volume strives to bring the readers the most up-to-date information on the newest aspects of synthesis of oligo nucleotides and their analogs. A separate volume covers synthesis of oligonucleotide conjugates, along with most of the analytical techniques presently used for analysis of oligonucleotides.
Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
...comprehensive and authoritative definitely required reading for the would-be oligonucleotide chemist and for those involved in biological applications of oligonucleotides... - Journal of Pharmacy and Pharmacology
A Brief History of Oligonucleotide Synthesis. Oligonucleotide Synthesis: Phosphotriester Approach. Oligodeoxyribonucleotide Synthesis: Phosphoramidite Approach. Oligodeoxynucleotide Synthesis: H-Phosphonate Approach. Oligoribonucleotide Synthesis: The Silyl-Phosphoramidite Method. Synthesis of 2'-O-Alkyloligoribonucleotides. An Improved Method for the Synthesis and Deprotection of Methylphosphonate Oligonucleotides. Oligonucleotide Phosphorothioates. Synthesis and Purification of Phosphorodithioate DNA. Oligodeoxyribonucleotide Phosphotriesters. Oligonucleotide Boranophosphate (Borane Phosphate). Oligonucleotide Phosphorofluoridates and Fluoridates. a-Oligonucleotides. Stereospecific Synthesis of P-Chiral Analogs of Oligonucleotides. Oligonucleotide Analogs with Dimethyl-Sulfide, -Sulfoxide, and -Sulfone Groups Replacing Phosphodiester Linkages. Oligonucleotide Analogs Containing Dephosphointernucleoside Linkages. Scaleup of Oligonucleotide Synthesis: Solution Phase. Large Scale Oligonucleotide Synthesis Using Solid Phase Approach. Solid-Phase Supports in Oligonucleotide Synthesis. Index.
Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.
Spese di spedizione:
EUR 14,11
Da: Regno Unito a: U.S.A.
Spese di spedizione:
GRATIS
In U.S.A.
Da: Anybook.com, Lincoln, Regno Unito
Condizione: Good. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. Clean from markings. In good all round condition. Codice articolo 9928088
Quantità: 1 disponibili
Da: Basi6 International, Irving, TX, U.S.A.
Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. Codice articolo ABEJUNE24-317434
Quantità: 2 disponibili
Da: BennettBooksLtd, North Las Vegas, NV, U.S.A.
paperback. Condizione: New. In shrink wrap. Looks like an interesting title!. Codice articolo Q-0896032477
Quantità: 1 disponibili
Da: GreatBookPrices, Columbia, MD, U.S.A.
Condizione: New. Codice articolo 7814725-n
Quantità: 5 disponibili
Da: booksXpress, Bayonne, NJ, U.S.A.
Soft Cover. Condizione: new. Codice articolo 9780896032477
Quantità: 10 disponibili
Da: Ria Christie Collections, Uxbridge, Regno Unito
Condizione: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Codice articolo ria9780896032477_lsuk
Quantità: Più di 20 disponibili
Da: Lucky's Textbooks, Dallas, TX, U.S.A.
Condizione: New. Codice articolo ABLIING23Mar2317530030225
Quantità: Più di 20 disponibili
Da: GreatBookPricesUK, Castle Donington, DERBY, Regno Unito
Condizione: New. Codice articolo 7814725-n
Quantità: 5 disponibili
Da: moluna, Greven, Germania
Condizione: New. Codice articolo 385688171
Quantità: Più di 20 disponibili
Da: GreatBookPrices, Columbia, MD, U.S.A.
Condizione: As New. Unread book in perfect condition. Codice articolo 7814725
Quantità: 5 disponibili