Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book's high profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.
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...a timely addition to the literature in this field... strongly recommended both to scientists already engaged in antisense research and to newcomers alike...a 'must' for all those wishing to 'stop making sense' with nucleic acid therapeutics in in vivo studies. -Trends in Biotechnology
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Hardcover. Condizione: Fine. 0896033058. Unread Pictorial board hardcover, from closed pharmaceutical company library. Lending record shows this book has never been borrowed. 276 pages, index, illustrated with charts, tables and diagrams. Analysis of the development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. Discusses such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system. Contents clean, tight and bright. Book. Codice articolo 031934
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