Principles of Molecular Medicine - Rilegato

Jameson, J-Larry

Rilegato

ISBN 10: 0896035298 ISBN 13: 9780896035294

Casa editrice: Humana Press, 1998

Riassunto

This is the first major textbook of molecular medicine to integrate the newest findings from cell and molecular biology with the basic principles of internal medicine. J. Larry Jameson, MD and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide array of disciplines - including neurology, cardiology, hematology, nephrology, genetics, endocrinology, oncology, dermatology, psychiatry, and infectious diseases - revealing the underlying molecular mechanisms of disease, as well as the routes to unprecedented novel medicines and treatments now emerging from the new molecular approaches. Here physicians will find informative updates in both their own specialties and in disciplines they may not have been able to follow closely. They will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more. This groundbreaking and uniquely valuable new approach to human medical biology will provide practicing physicians, medical students, and researchers alike with a powerful new account of internal medicine and help them to better understand the future of medicine.

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Winner of the Book of the Year Award from Doody's Health Science Book Review Journal
"The selection of topics, the ability of the contributors to present complex topics in a clear, concise manner, and the format should all contribute to making this book the standard text and reference in its field. It should be in the collection of every medical library and on the bookshelf of every physician interested in keeping up with the transformation of medicine by molecular genetics." 5 Stars-Doody's Health Science Book Review Journal.

"...bridge[s] the current gap between basic science and the bedside. It will thus be useful to researchers and clinicians alike. With more than 100 chapters covering a wide variety of topics, its distinguished cohort of section editors, and its abundant tables and illustrations, it provides an accessible and much needed manual to the present and the future of molecular genetics."-Francis S. Collins, MD, PhD

"...a first-class reference textbook. The format of this book is easy to follow and is relevant to the way in which medicine is currently practiced. Its division into the traditional disciplines of medicine makes it easy to identify how molecular developments have enhanced our medical knowledge, diagnostic potentials and therapeutic options...The editor-in-chief, his section editors and the contributing authors should all be congratulated on a superb job."-Molecular Medicine Today

"Because molecular medicine has already started to become an integral part of medical practice, there is a growing need to integrate it into the medical school curriculum and medical education in general. Principles of Molecular Medicine is well suited to serving this purpose. . .closing the gap between basic science and the bedside. The book is organized according to organ systems and comprises more than 120 chapters, each written by outstanding specialists. . .The various facets of human hereditary disorders, including genetic counseling and molecular diagnostic testing, are clearly and comprehensively presented. . .the book is well written and attractive. . .[and] is a valuable resource that will certainly appeal to clinicians, researchers, teachers, and students alike. It will also be of value to those involved in a particular area of molecular medicine who need a reference manual in which to find information on aspects of the field in which they are less familiar. . .a valuable reference for anyone with an interest in the achievements and the potential of molecular medicine."-Michael Goosens, MD review in the May 20, 1999 issue of the New England Journal of Medicine

Contenuti:

Part I. Introduction To Molecular Medicine, Andrea Ballabio, and J. Larry Jameson . Organization of the Human Genome, Chromosomes, and Genes, Sarah H. Elsea and Pragna I. Patel. Recombinant DNA and Genetic Techniques, Marcus Grompe, Wade Johnson, and J. Larry Jameson. Transcriptional Control of Gene Expression, Wade Johnson and J. Larry Jameson. Transmission of Human Genetic Disease, Peter Kopp and J. Larry Jameson. The Human Genome Project, J. Larry Jameson. The Cell Cycle, Lynda Q. Nguyen and J. Larry Jameson. Oncogenes and Tumor Suppressor Genes, J. Larry Jameson. Molecular Diagnostic Testing, C. Sue Richards and Patricia A. Ward. Genetic Counseling, Beth A. Fine. Transgenic Mice as Models of Disease, T. Rajendra Kumar and Martin M. Matzuk. Part II. Cardiology Anthony Rosenzweig. Molecular Cardiology: An Overview, Anthony Rosenzweig. Congenital Heart Disease: Inherited Cardiomyopathies, Christine E. Seidman, Calum MacRae, and J. G. Seidman. Coronary Atherosclerosis, Robert E. Gerszten and Anthony Rosenzweig. Endothelium-Derived Nitric Oxide and Control of Vascular Tone, Santiago Lamas and Thomas Michel. Hypertension, George Koike and Howard J. Jacob. Cardiac Arrhythmias, Barry London. Cardiovascular Gene Therapy, Giuseppe Vassalli and David A. Dichek. Part III. Hematology, Swee Lay Thein. Hematopoiesis: Growth Factors and Mechanisms of Regulation, Andrew Haynes and Nigel Russell. Disorders of Hemoglobin Structure and Synthesis, Swee Lay Thein and Jacques Rochette.Disorders of the Red Cell Membrane, Jean Delaunay. Red Cell Enzymopathies, Lucio Luzzatto and Rosario Notaro. Coagulation Disorders, Martina Daly, Anne Goodeve, Peter Winship, and Ian Peake. Thrombotic Disorders, Robin J. Olds, David A. Lane, and Swee Lay Thein. Paroxysomal Nocuturnal Hemoglobinuria, Bruno Rotoli and Khedoudja Nafa. Leukemias, Jeffrey E. Rubnitz and Ching-Hon Pui . Lymphomas, Finbarr E. Cotter . Part IV. Immnology, Ralph C. Williams, Jr. Regulation of Humoral Immunity, Ralph C. Williams, Jr. Molecular Regulation of Cellular Immunity, Eric Sobel. Cytokines, William L. Lowe, Jr., and Barbara A. da Silva. The HLA Complex, Robert W. Karr. Inherited Immune Deficiency, Richard Hong. Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (AIDS), John W. Sleasman and Maureen M. Goodenow. Autoimmune Diseases, N. Lawrence Edwards.Allergic Diseases: Asthma as a Model, Susan M. MacDonald. Part V. Pulmonolgy, Michael J. Holtzman. Asthma, Michael J. Holtzman, Dwight C. Look, Michael F. Iademarco, Douglas C. Dean, Deepak Sampath, and Mario Castro. Cystic Fibrosis, Daniel B. Rosenbluth and Steven L. Brody. Pulmonary Emphysema, Steven D. Shapiro and Robert M. Senior Surfactant Deficiency, Jeffrey A. Whitsett and Timothy E. Weaver. Lung Cancer: The Role of Tumor Suppressor Genes, Steven Jay Weintraub. Part VI. Gastroenterology, James C. Reynolds. Hepatology, Piet C. de Groen and Nicholas F. LaRusso. Inherited Liver Disease, Juan Ruiz and George Y. Wu.Viral Hepatitis and Liver Disease, Sanjeev Gupta and Michael Ott. Pancreatic Exocrine Dysfunction, David Whitcomb and Jonathan Cohn. Small- and Large-Bowel Dysfunction, Deborah C. Rubin. Part VII. Endrocrinology, Michael J. McPhaul, md and J. Larry Jameson. Mechanisms of Hormone Action, William L. Lowe, Jr., Richard G. Pestell, Laird D. Madison, and J. Larry Jameson. Diabetes Mellitus, William L. Lowe, Jr. Pituitary Function and Neoplasia, Shlomo Melmed. Growth Hormone Deficiency Disorders, Joy D. Cogan and John A. Phillips III. Thyroid Disorders, Peter Kopp and J. Larry Jameson. Disorders of the Parathyroid Gland, Andrew Arnold and Andrew F. Stewart. Congenital Adrenal Hyperplasia, Robert C. Wilson and Maria I. New. Adrenal Diseases, Constantine A. Stratakis and George P. Chrousos. Multiple Endocrine Neoplasia Type 2, Robert F. Gagel, Sarah Shefelbine, and Gilbert Cote. Molecular Mechanisms of Hypoglycemia Associated with Increased Insulin Production, Pamela M. Thomas, Gilbert J. Cote, and Robert F. Gagel. Regulation of Reproduction, Michael J. McPhaul. Disorders of Sex Determination and Differentiation, Charmian A. Quigley. Sex Chromosome Disorders, Andrew R. Zinn. Disorders of Pubertal Development, Karen D. Bradshaw and Charmian A. Quigley. Defects of Androgen Action, Michael J. McPhaul. Testicular Diseases, Marco Marcelli. Ovarian Diseases, Elizabeth A. McGee and Nicholas A. Cataldo. Breast Cancer, Melora D. Berardo, D. Craig Allred, and Peter O'Connell. Part VIII. Nephrology. Dennis Ausiello. Renal Development, Vikas P. Sukhatme. Mechanisms of Leukocyte Extravasation, M. Amin Arnaout. Ischemic Acute Renal Failure, Joseph V. Bonventre. Potassium Secretory Channels in the Kidney, Steven C. Hebert. Alport Syndrome, Karl Tryggvason and Pirkko Heikkilä. Nephrogenic Diabetes Insipidus, Dennis Brown and Dennis A. Ausiello. Polycystic Kidney Disease, Gregory G. Germino and Luiz F. Onuchic. Renal Neoplasms: Wilms' Tumor and Renal-Cell Carcinoma, Kim E. Nichols and Daniel A. Haber. Part IX. Dermatology,ThomasS. Kupper. Congenital Diseases of Cutaneous Tissues. Selected Epidermal Gene Mutations. Introduction to Selected Epidermal Gene Mutations, Angela M. Christiano, Daniel B. Dubin, and Thomas S. Kupper. Epidermolysis Bullosa Simplex,Yiu-mo Chan and Elaine Fuchs. Epidermolytic Hyperkeratosis, John J. DiGiovanna, Sherri J. Bale, and Peter M. Steinert. Mosaicism and Epidermal Nevi, Amy S. Paller. Darier's Disease and Hailey-Hailey Disease, Lowell A. Goldsmith and Ervin Epstein, Jr. Junctional Forms of Epidermolysis Bullosa, Angela M. Christiano and Jouni Uitto. The Dystrophic Forms of Epidermolysis Bullosa, Jouni Uitto and Angela M. Christiano . Genetic Mutations that Predispose to Cancer. Oculocutaneous Albinism, Jean L. Bolognia. Basal Cell Nevus Syndrome, Ervin Epstein, Jr. Xeroderma Pigmentosa and Related Disorders, W. Clark Lambert, Hon-Reen Kuo, and Muriel W. Lambert. The Skin as a Vehicle for Gene Therapy, Soosan Ghazizadeh, Tadeusz M. Kolodka, and Lorne B. Taichman. Acquired Diseases of Cutaneous Tissues. Acquired Diseases of Cutaneous Tissues: Introduction, Thomas S. Kupper. Basal- and Squamous-Cell Carcinoma, Paul Nghiem and Thomas S. Kupper. Melanoma Genetics, Daniel B. Dubin and Saumyen Sarkar. Psoriasis, James T. Elder and John J. Voorhees. Atopic Dermatitis and Atopy, Donald Y. M. Leung and Larry Borish. Pemphigus Foliaceus and Pemphigus Vulgaris, Janet A. Fairley, Xiang Ding, George J. Giudice, and Luis A. Diaz. Bullous Pemphigoid, Cicatrical Pemphigoid, and Pemphigoid Gestationis, Grant J. Anhalt and Diya F. Mutasim. Cutaneous Lupus Erythematosus, Richard D. Sontheimer. Scleroderma (Systemic Sclerosis) and Morphea, Edwin A. Smith and E. Carwile LeRoy. Part X. Musculoskeletal, Laurence Kedes. Muscle Development and Differentiation, Eric N. Olson. Skeletal Muscle Structure and Function, Henry F. Epstein. Muscular Dystrophies, Eric P. Hoffman. Rhabdomyosarcomas, Stephen J. Tapscott. Part XI. Neurology, Joseph B. Martin. Molecular Neurobiology, Joseph B. Martin and Frank M. Longo. Huntington's Disease, Marcy E. MacDonald. Molecular Genetics of Alzheimer's Disease, P. H. St. George-Hyslop. Amyotropic Lateral Sclerosis and Related Motor Neuron Diseases, Meret E. Cudkowicz and Robert H. Brown, Jr. Spinocerebellar Ataxia and Other Disorders of Trinucleotide Repeats, Huda Y. Zoghbi. Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies, James R. Lupski. Molecular and Genetic Basis of Prion Diseases, Stanley B. Prusiner. Genetic Basis of Mitochondrial Disease, Donald R. Johns. Malignant Hyperthermia and Central Core Disease, David H. MacLennan and Beverley A. Britt. Retinoblastoma: A Current Review, Joan M. O'Brien. Neurofibromatosis: Type 1 and Type 2, Jaime O. Claudio and Guy A. Rouleau. Brain Tumors, Mark A. Israel. Part XII. Psychiatry, Charles B. Nemeroff. Molecular Mechanisms and Regulating Behavior, Paul M. Plotsky and Charles B. Nemeroff. Schizophrenia, Ming T. Tsuang and Stephen V. Faraone. Affective Disorders, Francis J. McMahon and J. Raymond DePaulo, Jr. Alcoholism, Eric J. Devor and Arthur Falek. Part XIII. Genetic Basis of Congentical Malformations, Ethylin Wang Jabs. Waardenburg Syndrome, Andrew P. Read. Greig Cephalopolysyndactyly Syndrome and Limb Disorders, Karl-Heinz Grzeschik. Fibroblast Growth Factor Receptor-Related Skeletal Disorders: Craniosynostosis and Dwarfism Syndromes, Maximilian Muenke, Clair A. Francomano, M. Michael Cohen, Jr., and Ethylin Wang Jabs. Aarskog-Scott Syndrome, Jerome L. Gorski. Beckwith-Wiedemann Syndrome, Ellen R. Elias, Michael R. DeBaun, and Andrew P. Feinberg. Prader-Willi and Angelman Syndromes, Robert D. Nicholls. Fragile X Syndrome, David L. Nelson. Down Syndrome, Stylianos E. Antonarakis. The 22q11 Deletion: DiGeorge and Velocardiofacial Syndrome, Deborah A. Driscoll and Beverly S. Emanuel. Orofacial Clefting, Jacqueline T. Hecht and Susan H. Blanton. Molecular Genetics of Hearing Disorders, William J. Kimberling. Index.

Su questa edizione

• Editore: Humana Press
• Data di pubblicazione: 1998
• ISBN 10: 0896035298
• ISBN 13: 9780896035294
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 1123