Evolving Methods for Macromolecular Crystallography: The Structural Path to the Understanding of the Mechanism of Action of CBRN Agents: 245 - Brossura

Brossura

ISBN 10: 1402063156 ISBN 13: 9781402063152

Casa editrice: Springer, 2007

Riassunto

This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis. The book shows how modern high-throughput methods are contributing to a deeper understanding of medical problems.

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Recensione

From the reviews:

"The book is a summary of the proceedings on ‘Evolving Methods for Macromolecular Crystallography’ held in 2005. ... it is a welcome addition to the crystallographer’s bookshelf with contributions by a number of experts in their field." (Miroslav Papiz, Crystallography Reviews, Vol. 15 (2), 2009)

Contenuti

Preface. Succeeding with Seeding: some practical Advice; T. Bergfors.- Expression, Purification and Crystallisation of membrane Proteins; Bernadette Byrne.- Macromolecular Cryo-Crystallography; E. Garinan.- Processing Diffraction Data with Mosfim; A.G. W. Leslie and H.R. Powell.- SAD Phasing: basic Concepts and High-Throughput; G.M. Sheldrick.- Likelihood-based experimental phasing in Phaser; A.J. McCoy, L. C. Storoni and R. J. Read.- Stochastic molecular Replacement; N. M. Glykos.- Likelihood-based molecular Replacement in Phaser; R. J. Read et al.- Automated Structure Determination with PHENIX ; P. D. Adam et al.- Density Modification in MAIN; D. Turk.- Ab initio Phasing starting from Low Resolution; V.Lunin et al. Structural Genomics of Mycobacterium tuberculosis - a Search for Function and new Drug Targets; T. Baker.- 3D Domain Swapping and its Relevance to conformational Diseases; M. Jaskolski.- Structural Bioinformatics: From PROTEIN Structure to Function; J.D. Watson et al.- Single-particle Imaging; D. Sayre.-

Su questa edizione

• Editore: Springer
• Data di pubblicazione: 2007
• ISBN 10: 1402063156
• ISBN 13: 9781402063152
• Rilegatura: Copertina flessibile
• Numero di pagine: 200
• Redattore: Read Randy J., Sussman Joel L.