Articoli correlati a The ADAM Family of Proteases: 4
The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.
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Contenuti:
Contributing Authors; Preface; Chapter 1: INTRODUCTION TO THE ADAM FAMILY, Judith White, Lance Bridges, Douglas DeSimone, Monika Tomczuk and Tyra Wolfsberg; Chapter 2: STUDIES FROM ADAM KNOCKOUT MICE, Keisuke Hoiruchi and Carl P. Blobel; Chapter 3: ADAM8/MS2/CD156a, Jörg W. Bartsch, Silvia Naus, Andrea Rittger, Uwe Schlomann, Dirk Wildeboer; Chapter 4: ADAM9, Shoichi Ishiura; Chapter 5: ADAM10, Paul Saftig and Dieter Hartmann; Chapter 6: ADAM12, Ulla M. Wewer, Reidar Albrechtsen and Eva Engvall; Chapter 7: Adam13 function in development, Dominique Alfandari, Chapter 8: ADAM 17, Joaquín Arribas and Soraya Ruiz-Paz; Chapter 9: ADAM19, Tiebang Kang, Robert G. Newcomer, Yun-Ge Zhao and Qing-Xiang Amy Sang;Chapter 10: ADAM28, Anne M. Fourie; Chapter 11: MAMMALIAN ADAMS WITH TESTIS-SPECIFIC OR -PREDOMINANT EXPRESSION, Chunghee Cho; Chapter 12: OVERVIEW OF ADAMTS PROTEINASES AND ADAMTS 2, Daniel S. Greenspan and Wei-Man Wang;Chapter 13: ADAMTS-3 AND ADAMTS-14, Carine Le Goff and Suneel S. Apte; Chapter 14: ADAMTS-4 AND ADAMTS-5, Anne-Marie Malfait, Micky Tortorella and Elizabeth Arner; Chapter 15: ADAMTS-13, Han-Mou Tsai; Index.
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- EditoreSpringer
- Data di pubblicazione2011
- ISBN 10 1441937757
- ISBN 13 9781441937759
- RilegaturaCopertina flessibile
- Numero di pagine360
- RedattoreHooper Nigel M, Lendeckel Uwe
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Descrizione libro Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer's amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis. Codice articolo 9781441937759
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Descrizione libro Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The ADAM Family of Proteases will be a timely and useful source of information both for those immersed in the field and those just entering this exciting and rapidly expanding field of research. The individual chapters have been written by pioneers and e. Codice articolo 4174156
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Descrizione libro Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer's amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis. 360 pp. Englisch. Codice articolo 9781441937759
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Descrizione libro Condizione: New. Editor(s): Hooper, N. M.; Lendeckel, Uwe. Series: Proteases in Biology and Disease. Num Pages: 344 pages, biography. BIC Classification: PSBZ. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 18. Weight in Grams: 505. . 2010. 1st ed. Softcover of orig. ed. 2005. Paperback. . . . . Codice articolo V9781441937759
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Descrizione libro Condizione: New. Editor(s): Hooper, N. M.; Lendeckel, Uwe. Series: Proteases in Biology and Disease. Num Pages: 344 pages, biography. BIC Classification: PSBZ. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 18. Weight in Grams: 505. . 2010. 1st ed. Softcover of orig. ed. 2005. Paperback. . . . . Books ship from the US and Ireland. Codice articolo V9781441937759
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