Biochemistry of Pulmonary Emphysema - Brossura

Brossura

ISBN 10: 1447137736 ISBN 13: 9781447137733

Casa editrice: Springer, 2014

Riassunto

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

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Contenuti

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.

Dettagli dell'edizione

• Editore: Springer
• Data di pubblicazione: 2014
• Lingua: Inglese
• ISBN 10: 1447137736
• ISBN 13: 9781447137733
• Rilegatura: Copertina flessibile
• Numero di pagine: 220
• Redattore: Grassi C., Travis J., Casali L., Luisetti M.
• Contatto del produttore: non disponibile
• Persona responsabile: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3,69115 Heidelberg, Germany; Heidelberg; 69115; Germania