A Case Approach to Perioperative Drug-Drug Interactions - Brossura

Brossura

ISBN 10: 1461474949 ISBN 13: 9781461474944

Casa editrice: Springer Nature, 2015

Riassunto

The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, as well as trainees in both specialties; intensive care staff, including physicians, physician’s assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.

Su questo libro

L'autore:

Catherine Marcucci, MD

Anesthesia Services Department

Philadelphia Veterans Affairs Medical Center

Philadelphia, PA, USA

Michael P. Hutchens, MD, MA

Department of Anesthesiology & Perioperative Medicine

Oregon Health & Science University

Portland, OR, USA

Erica D. Wittwer, MD, PhD

Department of Anesthesiology

Mayo Clinic

Rochester, MN, USA

Toby N. Weingarten, MD

Department of Anesthesiology

Mayo Clinic

Rochester, MN, USA

Juraj Sprung, MD, PhD

Department of Anesthesiology

Mayo Clinic

Rochester, MN, USA

Wayne T. Nicholson, MD, PharmD, MSc

Department of Anesthesiology

Mayo Clinic

Rochester, MN, USA

Kirk Lalwani, MD, FRCA, MCR

Department of Anesthesiology & Perioperative Medicine

Oregon Health & Science University

Portland, OR, USA

David G. Metro, MD

Department of Anesthesiology

University of Pittsburgh School of Medicine

Pittsburgh, PA, USA

Randal O. Dull, MD, PhD

Department of Anesthesiology

University of Illinois at Chicago

Chicago, IL, USA

Christopher E. Swide, MD

Department of Anesthesiology & Perioperative Medicine

Oregon Health & Science University

Portland, OR, USA

F. Jacob Seagull, PhD

Department of Medical Education

University of Michigan Medical School

Ann Arbor, MI, USA

Jeffrey R. Kirsch, MD

Department of Anesthesiology & Perioperative Medicine

Oregon Health & Science University

Portland, OR, USA

Neil B. Sandson, MD

Department of Psychiatry

University of Maryland Medical System

Department of Psychiatry

VA Maryland Health Care System

Baltimore, MD, USA

Contenuti:

Part I. Introduction to Drug-Drug Interactions

1. Let’s Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions

F. Jacob Seagull, PhD, Catherine Marcucci, MD

2. Pharmacodynamic Interactions:  Core Concepts

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

3. Pharmacokinetic Interactions:  Core Concepts

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

4. A Brief Treatise On The Area Under The Curve

Michael J. Sikora, MD, Barbara Jericho, MD

Part II. Introduction to Drug-Drug Interactions:  Brief Review of CYP450 Enzymes, UGTs, and Transporters

5. CYP2D6:  Where It All Began

John C. Sanders, MBBS, FRCA, Rachel Koll, MD, Randal O. Dull, MD, PhD                               

6. CYP2E1:  The Anesthesia Enzyme

Benjamin S. Gmelch, MD, Randal O. Dull, MD, PhD

7. CYP3A4:  The Workhorse

Jennifer DeCou, MD, Nathaniel Birgenheier, MD, Randal O. Dull, MD, PhD

8. CYP1A2:  The Switch-hitter

Danielle Roussel, MD, Emily Hagn, MD, Randal O. Dull, MD, PhD

9. CYP2B:   2B or Not 2B?

Dustin Coyle, MD, Randal O. Dull, MD, PhD

10. CYP2C9:  The Support Crew I

Byron Douglas Fergerson, MD, Crystal B. Wallentine, MD, Randal O. Dull, MD, PhD

11. CYP2C19:   The Support Crew II

Barbara Jericho, MD, Alfredo Aguiar, MD, Randal O. Dull, MD, PhD

12. UGTs:  Conjugating Cousins

Neil B. Sandson, MD

13. The Cytochrome P450 System In Disease States―A Brief Review

Catherine Marcucci, MD

PART III.   Drug-Drug Interactions:  Paradigms and Core Concepts

14. P-glycoprotein and OATP Transporters

Dustin Coyle MD, Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD

15. The  “Fatal” Forty

Neil B. Sandson MD, Michael Hutchens MD, F. Jacob Seagull, PhD, Catherine Marcucci, MD

16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions

Neil B. Sandson, MD, Catherine Marcucci, MD

17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma

Neil B. Sandson, MD, F. Jacob Seagull, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD 

18. Pharmacogenomics

Chad D. Moore, PhD, William Hartman, MD, PhD, Michael Hutchens, MD, Randal O. Dull, MD, PhD

19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important

Joseph A. Lovely, PharmD, BCPS, Stephen Esper, MD, MBA, Michael Hutchens, MD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD

20. The Lawyers Can Read, Too:  Case Presentations from the Courtroom

Jessica Voge, MD, David K. Miller, JD

Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents

21. Introduction

Catherine Marcucci, MD

22. That Sums It Up 

Volatile anesthetics, additive MACs

James A. Jernigan, MD, James W. Ibinson, MD, PhD

23. 1+1+1+1=? 

Variable effects of combined substances

Anthony T. Silipo, DO, Raymond M. Planinsic, MD, Erica D. Wittwer, MD, PhD, Juraj Sprung MD,PhD, Wayne T. Nicholson, MD, PharmD, MSc

24. A Delayed Surgeon Is A “Dismayed” Surgeon?

Nitrous oxide, dexmedetomidine, somatosensory evoked potentials

Jonathan Anson, MD

25. Relax, It’s Only Gentamicin 

Volatile anesthetics, aminoglycoside antibiotics, neuromuscular junction

Brian Gierl, MD, Ferenc E. Gyulai, MD

26. Jaundice After Surgery 

Halothane hepatitis, CYP2E1

Jonathon E. Kivela, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD

27. Everybody Clear? 

Halothane, epinephrine arrhythmia

Nikhli Patel, MD, Barbara Jericho MD, Randal O. Dull, MD, PhD

28. The Hemodynamic Hole 

general anesthetics, ACE-I, ARBs

Arun L. Jayaraman, MD, PhD, Theresa A. Gelzinis, MD

29. Alpha-2 To The Rescue But Beware Bradycardia 

volatile anesthetics, alpha-2 agents

Phillip Adams, DO, Nashaant N. Rizk, MD

30. Hot Stuff! 

triggering drugs, ryanodine receptor, malignant hyperthermia

Cornelius B. Groenewald, MD, ChB, Juraj Sprung, MD, PhD

Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents

31. Introduction

Catherine Marcucci, MD

32. How to Successfully Occlude an Intravenous Line 

thiopental, succinylcholine, line precipitation

Helga Komen, MD, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD      

33. A Curious Cause of Seizures 

ketamine, theophylline

Charles Galaviz, MD, Randal O. Dull, MD, PhD

34. Magnesium Mama And The Mad Dad 

magnesium sulfate, propofol, remifentanil, vecuronium

Ana Maria Manrique MD, Catherine Marcucci, MD, Kathirvel Subramaniam, MD

35. Dexy’s Midnight Spinal 

dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6

Michael Hutchens, MD, Edward A. Kahl, MD, Matthias J. Merkel, MD, PhD

Part VI. Drug-Drug Interactions Involving Local Anesthetics 

36. Introduction

Catherine Marcucci, MD

37. Comfortably Numb 

local anesthetics

Joseph J. Yurigan, DO, Todd M. Oravitz, MD

38. Naturally Occurring And Nasty 

cocaine, propranolol

Lauren Partyka, MD, Li Meng, MD, MPH

39. LOL-LOL:  Little Old Lady―Lots of Lido 

lidocaine, bupivacaine

Kitling M. Lum, RN, BSN, CCRN-CSC, Kelly N. Stafford, BSN, CCRN, CSC

40. The Spinal Countdown 

general anesthesia after spinal anesthesia

Audra M. Webber, MD, Franklyn P. Cladis, MD, FAAP

41. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity?  Smoking Gun I 

Fatal Forty DDI:  ropivacaine, fluoxetine, CYP1A2, CYP3A4

L. Michele Noles, MD

42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity?  Smoking Gun II 

Fatal Forty DDI:  bupivacaine, methocarbamol

L. Michele Noles, MD

43. A Perfect Storm? 

Fatal Forty DDI:  omeprazole, nicardipine, diltiazem, bupivacaine, CYP3A4, CYP2C19, CYP2D6

J. Andrew Dziewit, MD, Nabil M. Elkassabany, MD

44. Shake Rattle and Roll 

Fatal Forty DDI:  lidocaine, cimetidine, CYP3A4

Hans P. Sviggum, MD, Juraj Sprung, MD, PhD

45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult

lidocaine, metoprolol

Katarina Bojanić, MD, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD

46. Fatal Pain Relief 

local anesthetics, intrathecal morphine

Matthew M. Kumar, MD, Richard Levi Boortz-Marx, MD, MS

47. Lipid Lifesaver 

local anesthetic, lipid emulsion

Adrian Pichurko, MD, Guy Weinberg, MD

Part VII. Drug-Drug Interactions Involving Opioids 

48. Introduction

Toby N. Weingarten, MD

49. No ‘Subs’titute for Sobriety

buprenorphine, mu agonist opioids

James Hilliard, MSN, CRNA, Kirk Lalwani, MD, FRCA, MCR

50. A Needle And The Damage Done 

Fatal Forty DDI:  buprenorphine, ritonavir, CYP3A4

James Hilliard, MSN, CRNA, Kirk Lalwani, MD, FRCA, MCR

51. Dad’s Not Having Much Pain

Fatal Forty DDI:  methadone, ciprofloxacin, CYP3A4

Rani Chovatiya, MD,  Mehmet S. Ozcan, MD, FCCP, Randal O. Dull, MD, PhD

52. Royal Flush 

Fatal Forty DDI:  methadone, nortriptyline, CYP2D6, CYP3A4

Kimberly Mauer, MD, Catherine Marcucci, MD, Neil B. Sandson, MD

53. The Worry That’s Always With Us:  Afternoon Nap 

oxycodone, diazepam

Syed M. Quadri, DO, Randal O. Dull, MD, PhD

54. The Bawling Baby

Fatal Forty DDI:  rifampin, methadone , CYP3A4, CYP2B6

Angela Kendrick, MD

55. Sleeping Beauty 

Fatal Forty DDI:  fentanyl, ritonavir, CYP3A4

Hans P. Sviggum, MD, Juraj Sprung, MD, PhD

56. Codeine Can’t Do It 

Fatal Forty DDI:  codeine, fluoxetine, CYP2D6

Katarina Bojanić, MD, Wayne T. Nicholson MD PharmD, MSc, Erica D. Wittwer MD, PhD, Toby N. Weingarten MD, Juraj Sprung, MD, PhD

57. A Shuddering Interaction 

meperidine, phenelzine,  serotonin toxicity

Christine A. Kenyon Laundre, MD, Randall Flick, MD, Juraj Sprung, MD, PhD

58. Double Indemnity

Fatal Forty DDI:  morphine, rifampin, P-glycoprotein

Lisa Chan, MD, Catherine Marcucci, MD, Neil B. Sandson, MD, Kirk Lalwani, MD, FRCA, MCR

59. Breaking the Codeine 

Fatal Forty DDI:  codeine, quinidine CYP2D6

Clint Christensen, MD, Nathan G. Orgain, MD, Randal O. Dull, MD, PhD

60. The Ultimate Ultram Primer I:  My Mood Is Better, But Boy Do I Hurt!

Fatal Forty DDI:  tramadol, paroxetine, CYP2D6

Toby N. Weingarten MD, Juraj Sprung, MD, PhD

61. The Ultimate Ultram Primer II: I “Haight” Narcotics But I Hate Seizures Worse

Fatal Forty DDI:  tramadol, buproprion, seizures, CYP2D6

Bruce T. Dumser, MD, Neil B. Sandson, MD

62. The Ultimate Ultram Primer III:  Tremor-dol Trigger in Serotonin Syndrome

Fatal Forty DDI:  tramadol, paroxetine, 2D6 inhibition, serotonin syndrome

Bryan C. Hoelzer, MD, Stephanie Neuman, MD

63. Too Much of A Good Thing 

Fatal Forty DDI:  codeine, drug-gene interaction, CYP2D6

Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson MD, PharmD, MSc

Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications

64. Introduction

Toby N. Weingarten, MD

65. Pining For Pete In The Pain Clinic 

Fatal Forty DDI:  nortriptyline, paroxetine, CYP2D6

Steven S. Liu, MD, Toby N. Weingarten MD, Catherine Marcucci, MD

66. You Do Not Look Well Today, Mon Ami 

Fatal Forty DDI:  amitriptyline, amiodarone, QRS widening

Kimberly Mauer, MD, Catherine Marcucci, MD, Neil B. Sandson, MD

67. My Headache is Gone, But My Leg Now Hurts 

Fatal Forty DDI:  methysergide, erythromycin, CYP3A4

Jessica D. Lorenz, MD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

68. Special ‘K’ase 

Oral S-ketamine, ticlopidine

Lisa Chan, MD, Kirk Lalwani, MD, FRCA, MCR

69. Not Manic About NSAIDs 

Fatal Forty DDI:  ketorolac, lithium, toxicity

Allen N. Gustin, MD, FCCP, Michael J. Bishop, MD

70. Keep It Capped! 

acetominophen, ethanol

Christine M. Formea, PharmD, BCPS, Wayne T. Nicholson MD, PharmD, MSc

71. The ACE Is Not Always High

Fatal Forty DDI:  ketorolac, lisinopril

Wayne T. Nicholson, MD, PharmD, MSc

72. When The Smoke Clears, Relaxation Disappears 

Fatal Forty DDI:  cyclobenzaprine, smoked tobacco, CYP1A2

Avinash Ramchandani, MD, Julio A. Gonzalez-Sotomayor, MD

73. Befuddled by Aspirin 

Fatal Forty DDI:  aspirin, valproic acid, protein binding

Melisa N. Weingarten, RN, MS, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD

74. You Can’t Trick Us! 

Fatal Forty DDI:  ibuprofen, phenytoin, CYP2C9, protein binding

Catherine Marcucci, MD, Neil B. Sandson, MD

Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives

75. Introduction

Catherine Marcucci, MD

76. The Worry That’s Always With Us:  Now I’m Depressed

benzodiazepines, opioids, propofol

Kelly T. Peretich, MD, Raymond M. Planinsic, MD

77. The Worry That’s Always With Us: Tragic But Not Rare                                             alprazolam, clonazepam, and buprenorphine

Phillip Adams, DO, Ibtesam A. Hilmi, MB, CHB, FRCA

78. Lack of Sedation

Fatal Forty DDI:  midazolam, carbamazepine interaction, CYP3A4

Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

79. A Cold Isn’t Going to Slow Me Down

midazolam, goldenseal, CYP3A4, CYP3A5, CYP2D6

Leelee Thames, MD, Jessica Miller, MD, BM

80. Her Patients Never Wake Up On Time

Fatal Forty DDI:  midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7

Toby N. Weingarten, MD, Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

81. When Enough Is Now Too Much

Fatal Forty DDI:  midazolam, itraconazole, CYP3A4

Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

82. The Distressed Daughter

Fatal Forty DDI:  alprazolam, carbamazepine, CYP3A4

Jennifer Egan, MD, Kirk Lalwani, MD, FRCA, MCR, Catherine Marcucci, MD

83. Check Check and Double Check

Fatal Forty DDI:  diazepam, fluvoxamine, CYP3A4, CYP2C19

Catherine Marcucci, MD, Neil B. Sandson, MD

84. Doggone It―The Case is Cancelled

Fatal Forty DDI:  midazolam, lopinavir/ritonavir, CYP3A4

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Corinne Wisdo, DPM, Catherine Marcucci, MD

85. Noct’ Out

Fatal Forty DDI:  chloral hydrate, phenobarbital, furosemide

Michael Wollenberg, MD, Kirk Lalwani, MD, FRCA, MCR

86. Predisposed to Doze

promethazine, CYP2D6 poor metabolizer

Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson MD PharmD, MSc

87. Synergistic Sedation

Fatal Forty DDI:  midazolam, clozapine, synergism and clozapine, sertraline, CYP2D6

Michael Hutchens, MD, Paul Schipper, MD, FACS, FACCP, Catherine Marcucci, MD

Part X. Drug-Drug Interactions Involving Neuromuscular Blockade Agents

88. Introduction

David G. Metro, MD

89. Blocked Again

succinylcholine, repeated doses

Matthew Patrick Feuer, MD, Thomas M. Chalifoux, MD

90. Irreversibility Sux

succinylcholine, neostigmine

Joseph C. Shy, MD, David G. Metro, MD

91. Keep An “Ion” The Twitches

magnesium, neuromuscular blockade

Brian Gierl, MD, Ferenc E. Gyulai, MD

92. A Reversal of Misfortune

neostigmine, glycopryrolate,

Thomas N. Talamo, MD, Richard J. Kuwik, MD

93. Stop Moving

Fatal Forty DDI:  vecuronium, phenytoin              

Michael D. Olson, PA-C, Randall Flick, MD  

94. There’s Just Not Enough Roc In The World

Fatal Forty DDI:  rocuronium, carbamazepine

Tammara S. Goldschmidt, MD, Randal O. Dull, MD, PhD

95. Slow Sux I:  A Lengthy Wake-Up Period After Electroconvulsive Therapy

succinylcholine, atypical plasma cholinesterase

Jennifer A. Rabbitts, MB, ChB, Juraj Sprung, MD, PhD

96. Slow Sux II:  I Remember Reviewing This For The Boards

succinylcholine, atypical plasma cholinesterase

Andrew Oken, MD, Scott Richins, MD

97. Slow Sux III:  Where Did the Twitches Go?

succinylchol...

Su questa edizione

• Editore: Springer Nature
• Data di pubblicazione: 2015
• ISBN 10: 1461474949
• ISBN 13: 9781461474944
• Rilegatura: Copertina flessibile
• Numero edizione: 1
• Numero di pagine: 550
• Redattore: Marcucci Catherine M.D., Hutchens Michael P., Wittwer Erica D., Weingarten Toby N., Sprung Juraj