Chronic Myeloid Leukemia: Biology and Treatment - Rilegato

Rilegato

ISBN 10: 185317890X ISBN 13: 9781853178900

Casa editrice: CRC Press, 2001

Riassunto

In this volume, an international team of experts in chronic myeloid leukemia share their expertise. In particular, they contribute their insights on the latest advances in understanding this disease, and the implications those developments have for its management. They explore many topics, including a review of molecular and cellular biology, discussion of conventional chemotherapy and interferon therapy, and recent developments in allografting and autografting. The reader gains not only an incisive view of the biological structure of the disease, but applications of that biology to treatment modalities. Chronic Myeloid Leukemia is ideal for oncologists and other specialists in the field.

Su questo libro

Contenuti:

Part 1. Molecular Biology: BCR/ABL Gene Structure and BCR Function. BCR/ABL Protein Domain Function and Signaling. Adhesion/Integrin Abnormalities. Animal Models. Progenitor Cell Dynamics. Target-Directed Therapies. Complementation of Cytokine Signaling Pathways. Part 2. Conventional Therapy: IFN Dosage Regimens. Chemotherapy vs IFN. Biology of IFN. Prognostic Scores in CML. Chemotherapy and Combination Chemotherapy. IFN and Ara-C. Part 3. Allografting: Donor Selection. Prognostic Factors. Timing. Conditioning Regimens. Blood vs Marrow Stem Cells. Results with Sibling/Alternative Donors. Monitoring. Relapse. Basis of GVL. Donor Lymphocyte Infusions. Part 4. Autografting: Genetic Approaches to Treatment of CML. Specific Chemical Inhibitors of ABL Tyrosine Kinase. Immunotherapeutic Strategies. Autografting with Unmanipulated Stem Cells. Autografting with Cultured Marrow. Autografting with Ph-Negative Hematopoietic Progenitor Cells. Long-term Follow-up of Autologous Transplant Therapy. Target-Directed Therapies and ST1571.

Product Description:

Book by RDIGER HEHLMANN MD

Su questa edizione

• Editore: CRC Press
• Data di pubblicazione: 2001
• ISBN 10: 185317890X
• ISBN 13: 9781853178900
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 500
• Redattore: Carella Angelo M, Daley George Q, Eaves Connie J., Goldman John M, Rudiger Hehlmann