Protein Degradation in Health and Disease: v. 29 - Rilegato

Rilegato

ISBN 10: 3540425942 ISBN 13: 9783540425946

Casa editrice: Springer Nature, 2002

Riassunto

Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

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Contenuti:

Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth.- Aging of Proteins and the Proteasome.- Pathways of Protein Degradation and How They Are Affected by Age.- Protein Degradation in Alzheimer's Disease and Aging of the Brain.- Protein Degradation in Human Disease.- The 26S Proteasome.- Proteasome Inhibitors.

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Su questa edizione

• Editore: Springer Nature
• Data di pubblicazione: 2002
• ISBN 10: 3540425942
• ISBN 13: 9783540425946
• Rilegatura: Copertina rigida
• Numero di pagine: 140
• Redattore: Reboud-Ravaux Michele