Elements of Synthesis Planning

Valutazione media 0
( su 0 valutazioni fornite da Goodreads )
 
9783540792192: Elements of Synthesis Planning
Vedi tutte le copie di questo ISBN:
 
 

Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Recensione:

From the reviews:

“The text is recommended for those with a strong foundation in organic chemistry. ... The book would be quite helpful for those who plan syntheses on a regular basis ... . The text is a useful addition to the library of any synthetic organic chemist or to select undergraduate and graduate curricula. ... Readers will certainly learn more about the chemistry, the logic, and the art of planning a novel synthesis and contributing to a vast and interesting field.” (Bridget G. Trogden, Journal of Chemical Education, Vol. 88, 2011)

From an undergraduate learning perspective the concept of synthesis planning or retrosynthesis can appear to be a daunting prospect. The idea of being asked to think backwards for many is a big leap, despite the vast majority already possessing a well-stocked chemical toolbox and being more than capable to explain a multitude of complex mechanistic transformations. In Elements of synthesis planning, a reworked translation of his original German text, Reinhard Hoffmann sets out to 'demystify' the art of synthetic planning, which is an essential and vital skill practised every day throughout the worldwide organic chemistry community. 

In 12 clear and logical chapters, Hoffmann takes the reader from the basic concepts of retrosynthesis (use of synthons, identifying key bond disconnections, unmasking symmetry elements etc) to dedicated chapters on the application of chiral building blocks, strategic planning of complex synthetic sequences and the synthesis of polycyclic ring systems. In the final chapter, all these concepts are brought together to elegantly compare several individual approaches to one of five representative natural products, highlighting the tactics and strategies employed.  

As such, this text would ideally complement an advanced undergraduate course on complex organic synthesis, which is beyond the level of most standard organic chemistry textbooks. It would also prove highly useful to postgraduates at the beginning of their research careers in synthesis to inspire creativity and maybe put their ideas into practice. 

Gordon Florence , Chemistry World, 2009, 6(8), p. 63

Contenuti:

Functional Group Oriented Bond-Sets.- Skeleton Oriented Bond-Sets.- Building Block Oriented Synthesis.- The Basis for Planning.- Formation of Cyclic Structures.- Protecting Groups.- Ranking of Synthesis Plans.- Computer-Aided Synthesis Planning.- Stereogenic Centers and Planning of Syntheses.- Enjoying the Art of Synthesis.- Summary and Concluding Remarks.- Solutions to Problems.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

I migliori risultati di ricerca su AbeBooks

1.

R.W. Hoffmann
Editore: Springer (2009)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Quantità: > 20
Print on Demand
Da
Paperbackshop-US
(Wood Dale, IL, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Springer, 2009. PAP. Condizione: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo IQ-9783540792192

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 40,07
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 3,52
In U.S.A.
Destinazione, tempi e costi

2.

R. W. Hoffmann
Editore: Springer (2009)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Brossura Quantità: 15
Print on Demand
Da
Valutazione libreria
[?]

Descrizione libro Springer, 2009. Condizione: New. This item is printed on demand for shipment within 3 working days. Codice articolo LP9783540792192

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 43,24
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 3,79
Da: Germania a: U.S.A.
Destinazione, tempi e costi

3.

R.W. Hoffmann
Editore: Springer-Verlag Berlin and Heidelberg GmbH and Co. KG (2008)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Quantità: > 20
Print on Demand
Da
Books2Anywhere
(Fairford, GLOS, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Springer-Verlag Berlin and Heidelberg GmbH and Co. KG, 2008. PAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo LQ-9783540792192

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 38,18
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 10,35
Da: Regno Unito a: U.S.A.
Destinazione, tempi e costi

4.

Hoffmann, R. W.
Editore: Springer (2019)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Paperback Quantità: > 20
Print on Demand
Da
Murray Media
(NORTH MIAMI BEACH, FL, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Springer, 2019. Paperback. Condizione: New. Never used! This item is printed on demand. Codice articolo 3540792198

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 52,87
Convertire valuta

Aggiungere al carrello

Spese di spedizione: GRATIS
In U.S.A.
Destinazione, tempi e costi

5.

Hoffmann, R.W.
Editore: Springer-Verlag Berlin And Heidelberg Gmbh & Co. Kg (2009)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Paperback Quantità: 2
Da
Revaluation Books
(Exeter, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Springer-Verlag Berlin And Heidelberg Gmbh & Co. Kg, 2009. Paperback. Condizione: Brand New. 1st edition. 227 pages. 9.21x6.06x0.55 inches. In Stock. Codice articolo z-3540792198

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 47,86
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 8,62
Da: Regno Unito a: U.S.A.
Destinazione, tempi e costi

6.

R. W. Hoffmann (author)
Editore: Springer Berlin Heidelberg 2008-09-24, Berlin (2008)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo paperback Quantità: > 20
Da
Blackwell's
(Oxford, OX, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Springer Berlin Heidelberg 2008-09-24, Berlin, 2008. paperback. Condizione: New. Codice articolo 9783540792192

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 47,01
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 10,34
Da: Regno Unito a: U.S.A.
Destinazione, tempi e costi

7.

R. W. Hoffmann
Editore: Springer (2009)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Paperback Quantità: 1
Da
Ergodebooks
(RICHMOND, TX, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Springer, 2009. Paperback. Condizione: New. 2009. Codice articolo DADAX3540792198

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 56,63
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 3,52
In U.S.A.
Destinazione, tempi e costi

8.

R. W. Hoffmann
Editore: Springer
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Paperback Quantità: > 20
Da
BuySomeBooks
(Las Vegas, NV, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Springer. Paperback. Condizione: New. 227 pages. Dimensions: 9.2in. x 6.1in. x 0.6in.The total synthesis of compounds with interesting physical or biological properties is at the core of organic chemistry. Since only a small number of such compounds originate from natural sources, devising de novo routes to unique and artificial scaffolds requires the skills of planning and executing multi-step syntheses and having a toolbox of methodologies at ones disposal. Often, even the best plans require modifications, fine-tuning or entire rerouting, and chemists are faced with the daily challenge of choosing the right combination of reagents and building blocks for a whole set of problems: Which building blocks are optimal In which sequence should they be assembled Which reactions accomplish the task best This text focuses on these basic considerations that govern the planning and execution of a synthesis. The author details synthetic strategies, provides criteria for ranking different synthesis plans, and provides guidelines for optimizing syntheses. References to the original work provide the reader with a means of further study of the details and original considerations. The text takes a more in-depth look at synthesis than do standard organic chemistry textbooks and is a useful complement to other books on the market. Furthermore it includes problems and solutions. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Codice articolo 9783540792192

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 60,29
Convertire valuta

Aggiungere al carrello

Spese di spedizione: GRATIS
In U.S.A.
Destinazione, tempi e costi

9.

R.W. Hoffmann
Editore: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany (2009)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Paperback Quantità: 10
Da
The Book Depository EURO
(London, Regno Unito)
Valutazione libreria
[?]

Descrizione libro Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany, 2009. Paperback. Condizione: New. 2009 ed. Language: English. Brand new Book. Synthesis is at the core of organic chemistry. In order for compounds to be studied-be it as drugs, materials, or because of their physical properties- they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex "natural products" via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a "one-pot" operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield. Codice articolo AAV9783540792192

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 60,94
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 3,45
Da: Regno Unito a: U.S.A.
Destinazione, tempi e costi

10.

R. W. Hoffmann
Editore: Springer (2009)
ISBN 10: 3540792198 ISBN 13: 9783540792192
Nuovo Brossura Quantità: 1
Da
Irish Booksellers
(Portland, ME, U.S.A.)
Valutazione libreria
[?]

Descrizione libro Springer, 2009. Condizione: New. book. Codice articolo M3540792198

Informazioni sul venditore | Contattare il venditore

Compra nuovo
EUR 63,11
Convertire valuta

Aggiungere al carrello

Spese di spedizione: EUR 2,88
In U.S.A.
Destinazione, tempi e costi

Vedi altre copie di questo libro

Vedi tutti i risultati per questo libro