Articoli correlati a The Role of PYY in Regulating Appetite: PYY 1-36 versus...
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Obesity is the most prevalent nutritional problem in the industrial countries, which is going to be the futures predispose in the development of diseases like type 2 diabetes, osteoarthritis and cardiovascular diseases. It is essential to understand the physiology of normal appetite regulation in order to design an effective drug to treat the increase of obesity. The investigated peptide, PYY, exists in two forms, PYY1-36 and PYY3-36. Today there are 5 different receptors known where both forms bind to, but with different affinity. PYY3-36 has its highest affinity to the so called Y2 receptor. Both peptides play a crucial role in regulating appetite. PYY3-36 inhibits feeding in rodents, non-human primates and humans. The hypothalamus and brain stem are thought to be the brain areas responsible for regulating appetite. The goal of this work was to determine the activation of neurons in forebrain and hindbrain sites containing Y2 receptors and linked to control of food intake, when injecting PYY1-36 and PYY3-36. Wild type-like mice and Y2ko mice received a dose of PYY1-36 and PYY3-36 and the c-Fos expressing neurons were determined.
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L'autore
Isabella Kanzler, Dipl. - Ing. (FH): Studies in medical and pharmaceutical Biotechnology at the IMC Krems University of Applied Sciences. Scientific associate at the IMCAR, University Hospital Aachen.
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- EditoreVDM Verlag Dr. Müller
- Data di pubblicazione2008
- ISBN 10 3639107799
- ISBN 13 9783639107791
- RilegaturaCopertina flessibile
- Numero di pagine80
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The Role of PYY in Regulating Appetite : PYY 1-36 versus PYY 3-36
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Obesity is the most prevalent nutritional problem in the industrial countries, which is going to be the futures predispose in the development of diseases like type 2 diabetes, osteoarthritis and cardiovascular diseases. It is essential to understand the physiology of normal appetite regulation in order to design an effective drug to treat the increase of obesity.The investigated peptide, PYY, exists in two forms, PYY1-36 and PYY3-36. Today there are 5 different receptors known where both forms bind to, but with different affinity. PYY3-36 has its highest affinity to the so called Y2 receptor. Both peptides play a crucial role in regulating appetite. PYY3-36 inhibits feeding in rodents, non-human primates and humans. The hypothalamus and brain stem are thought to be the brain areas responsible for regulating appetite.The goal of this work was to determine the activation of neurons in forebrain and hindbrain sites containing Y2 receptors and linked to control of food intake, when injecting PYY1-36 and PYY3-36. Wild type-like mice and Y2ko mice received a dose of PYY1-36 and PYY3-36 and the c-Fos expressing neurons were determined. Codice articolo 9783639107791
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The Role of PYY in Regulating Appetite
Editore:
VDM Verlag Dr. Müller, 2008
ISBN 10: 3639107799
ISBN 13: 9783639107791
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Kartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Obesity is the most prevalent nutritional problem in the industrial countries, which is going to be the futures predispose in the development of diseases like type 2 diabetes, osteoarthritis and cardiovascular diseases. It is essenti. Codice articolo 4958117
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The Role of PYY in Regulating Appetite: PYY 1-36 versus PYY 3-36
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ISBN 10: 3639107799
ISBN 13: 9783639107791
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