The Extracellular Matrix: an Overview: An Overview (Biology of Extracellular Matrix) - Brossura

Brossura

ISBN 10: 364226719X ISBN 13: 9783642267192

Casa editrice: Springer, 2013

Riassunto

Covering a wide spectrum of topics including collagen types and the role of the ECM in human disease and pathogenesis, this volume is a timely overview of the structure, regulation, and function of the major macromolecules that form the extracellular matrix.

Su questo libro

Dalla quarta di copertina:

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling.

This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Contenuti:

An overview of extracellular matrix structure and function.-  Fibronectin and other adhesive glycoproteins.-  Collagen: suprastructures and collagen fibril assembly.-  Asement membrane; Hyaluronan and the Aggregating Proteoglycans.- The small, leucine-rich proteoglycans.- Microfibrils and fibrillin.- Elastin.- Lysyl oxidase and lysyl oxidase-like enzymes.- The Fibulins.- Matricellular proteins.

Su questa edizione

• Editore: Springer
• Data di pubblicazione: 2013
• ISBN 10: 364226719X
• ISBN 13: 9783642267192
• Rilegatura: Copertina flessibile
• Numero di pagine: 440
• Redattore: Mecham Robert