Interferon-Gamma: A marker of tuberculosis mediated immune response: University of Health Sciences, Lahore, Pakistan - Brossura

Hussain, Shahid; Afzal, Nadeem

Brossura

ISBN 10: 3659372404 ISBN 13: 9783659372407

Casa editrice: LAP LAMBERT Academic Publishing, 2013

Riassunto

Background: Interferon gamma (IFN-γ), a cytokine produced by a variety of cells is involved in the immune response against M.tuberculosis. It activates the production of other cytokines & molecules that kill MTB. IFN-γ also has diagnostic role in identification of active and latent TB. Objective: To determine the level of IFN-γ in the blood of TB patients. Methods: 91 subjects were selected, including 54 active TB patients and 37 healthy controls. IFN-γ conc. was determined in their blood by ELISA technique. Results: In TB patients, Mean+SD of IFN-γ was 48.69+28.78 while it was 12.99+5.70 pg/ml in control group (p <0.001). Significant differences in the level of IFN-γ were observed among confirmed TB patients, clinically diagnosed TB patients and the control group (Mean+SD 59.68+28.78, 36.85+24.76 and 12.99+5.70 pg/ml, respectively). Furthermore, a significant negative correlation was observed b/w conc. of IFN-γ in TB patients and the duration of anti-tuberculosis therapy. Conclusion: IFN-γ level was high in both clinically diagnosed and confirmed TB patients as compared to a control group. Measurement of IFN-γ is helpful to diagnose active TB, but further research is required.

Su questo libro

Informazioni sull?autore

M.Sc. in Medical Laboratory Technology: Studied immunology as subject of specialization at University of Health Sciences, Lahore. Served as Lab Manager & Teaching Research Fellow in the same University. Presently, working as Researcher (Fellow) at King Saud University, Riyadh. Future aims: career as well as education in Biomedical Sciences.

Dettagli dell'edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2013
• Lingua: Inglese
• ISBN 10: 3659372404
• ISBN 13: 9783659372407
• Rilegatura: Copertina flessibile
• Numero di pagine: 72
• Contatto del produttore: non disponibile
• Persona responsabile: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Germania