Articoli correlati a NEPHROTOXICITY: Major side effect of anti-cancer drug:...
Cisplatin (CDDP) is a major antineoplastic drug for the treatment of solid tumors such as metastatic bladder, testicular, and ovarian carcinomas. The drug can cause much toxicity, but the chief dose-limiting one is nephrotoxicity. Several, often interrelated mechanisms of actions have been hypothesized to induce the nephrotoxicity. These include apoptosis and inflammatory mechanism, production of tumor necrosis factor (TNF)-α by renal parenchymal cells, and generation of reactive oxygen species (ROS) that include superoxide dismutase, hydrogen radical, hydrogen peroxide, singlet oxygen, and nitric oxide. These techniques have proved to be only partially successful as acute renal failure occurs even at such low doses and especially after its repeated administration. The nephrotoxicity of cisplatin has been recognized since its introduction over 25 years ago. Early clinical use of cisplatin saw dose-related cisplatin-induced acute renal failure in 14 to 100% of patients, with the incidence varying with the cumulative dose. Clinical data have shown that approximately one third of patients experience kidney injury in days after cisplatin treatment, with reduced glomerular filtration.
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L'autore:
Dhairya Y. joshi (M.pharm) is a PG student at KLE UNIVERSITY’S COLLEGE OF PHARMACY, BELGAUM, KARNATAKA. Dr. A D Taranalli is a principal at KLE UNIVERSITY’S COLLEGE OF PHARMACY, BELGAUM, KARNATAKA. Priyanka P. Rana (M.pharm) KLE UNIVERSITY’S COLLEGE OF PHARMACY, BELGAUM, KARNATAKA.
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- EditoreLAP LAMBERT Academic Publishing
- Data di pubblicazione2013
- ISBN 10 3659384321
- ISBN 13 9783659384325
- RilegaturaCopertina flessibile
- Numero di pagine64
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NEPHROTOXICITY: Major side effect of anti-cancer drug: Drug-associated renal dysfunction
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Nephrotoxicity: Major Side Effect of Anti-Cancer Drug
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Nephrotoxicity: Major Side Effect of Anti-Cancer Drug
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NEPHROTOXICITY Major side effect of anticancer drug Drugassociated renal dysfunction
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ISBN 13: 9783659384325
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NEPHROTOXICITY: Major side effect of anti-cancer drug
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Descrizione libro Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Cisplatin (CDDP) is a major antineoplastic drug for the treatment of solid tumors such as metastatic bladder, testicular, and ovarian carcinomas. The drug can cause much toxicity, but the chief dose-limiting one is nephrotoxicity. Several, often interrelated mechanisms of actions have been hypothesized to induce the nephrotoxicity. These include apoptosis and inflammatory mechanism, production of tumor necrosis factor (TNF)- by renal parenchymal cells, and generation of reactive oxygen species (ROS) that include superoxide dismutase, hydrogen radical, hydrogen peroxide, singlet oxygen, and nitric oxide. These techniques have proved to be only partially successful as acute renal failure occurs even at such low doses and especially after its repeated administration. The nephrotoxicity of cisplatin has been recognized since its introduction over 25 years ago. Early clinical use of cisplatin saw dose-related cisplatin-induced acute renal failure in 14 to 100% of patients, with the incidence varying with the cumulative dose. Clinical data have shown that approximately one third of patients experience kidney injury in days after cisplatin treatment, with reduced glomerular filtration. 64 pp. Englisch. Codice articolo 9783659384325
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NEPHROTOXICITY: Major side effect of anti-cancer drug : Drug-associated renal dysfunction
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Descrizione libro Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Cisplatin (CDDP) is a major antineoplastic drug for the treatment of solid tumors such as metastatic bladder, testicular, and ovarian carcinomas. The drug can cause much toxicity, but the chief dose-limiting one is nephrotoxicity. Several, often interrelated mechanisms of actions have been hypothesized to induce the nephrotoxicity. These include apoptosis and inflammatory mechanism, production of tumor necrosis factor (TNF)- by renal parenchymal cells, and generation of reactive oxygen species (ROS) that include superoxide dismutase, hydrogen radical, hydrogen peroxide, singlet oxygen, and nitric oxide. These techniques have proved to be only partially successful as acute renal failure occurs even at such low doses and especially after its repeated administration. The nephrotoxicity of cisplatin has been recognized since its introduction over 25 years ago. Early clinical use of cisplatin saw dose-related cisplatin-induced acute renal failure in 14 to 100% of patients, with the incidence varying with the cumulative dose. Clinical data have shown that approximately one third of patients experience kidney injury in days after cisplatin treatment, with reduced glomerular filtration. Codice articolo 9783659384325
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NEPHROTOXICITY Major side effect of anticancer drug Drugassociated renal dysfunction
Editore:
LAP LAMBERT Academic Publishing
(2013)
ISBN 10: 3659384321
ISBN 13: 9783659384325
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Descrizione libro PAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo L0-9783659384325
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NEPHROTOXICITY: Major side effect of anti-cancer drug
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(2013)
ISBN 10: 3659384321
ISBN 13: 9783659384325
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