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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability: Formulation and In-vitro / In-vivo Evaluation - Brossura
Buccal delivery systems involves the administration of the drug through the buccal mucosal membrane lining of the oral cavity bypassing the first pass effect. Buspirone hydrochloride is an anxiolytic drug which undergoes extensive first-pass metabolism that results in very low oral bioavailability (4%). In addition, buspirone hydrochloride has short and variable elimination half-life (approximately 2.4 h). So it is a good candidate for the preparation of sustained release buccal dosage forms. The aim of this work was to formulate and evaluate buspirone hydrochloride buccal mucoadhesive cup and core tablets and sponges to sustain its action and improve its systemic bioavailability. The results of the in-vivo performance study confirmed that the prepared cup and core buccal tablets succeeded in increasing the bioavailability of buspirone 5.6 folds in comparison to the oral immediate release market product.
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- EditoreLAP LAMBERT Academic Publishing
- Data di pubblicazione2014
- ISBN 10 3659665932
- ISBN 13 9783659665936
- RilegaturaCopertina flessibile
- Numero di pagine328
- RedattoreRoshdy Fares Ahmed
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability: Formulation and In-vitro / In-vivo Evaluation
Editore:
LAP LAMBERT Academic Publishing
(2014)
ISBN 10: 3659665932
ISBN 13: 9783659665936
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Descrizione libro Condizione: New. Codice articolo ABLIING23Mar3113020299224
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability Formulation and Invitro Invivo Evaluation
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Descrizione libro PAP. Condizione: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo L0-9783659665936
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability
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ISBN 10: 3659665932
ISBN 13: 9783659665936
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Descrizione libro Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Buccal delivery systems involves the administration of the drug through the buccal mucosal membrane lining of the oral cavity bypassing the first pass effect. Buspirone hydrochloride is an anxiolytic drug which undergoes extensive first-pass metabolism that results in very low oral bioavailability (4%). In addition, buspirone hydrochloride has short and variable elimination half-life (approximately 2.4 h). So it is a good candidate for the preparation of sustained release buccal dosage forms. The aim of this work was to formulate and evaluate buspirone hydrochloride buccal mucoadhesive cup and core tablets and sponges to sustain its action and improve its systemic bioavailability. The results of the in-vivo performance study confirmed that the prepared cup and core buccal tablets succeeded in increasing the bioavailability of buspirone 5.6 folds in comparison to the oral immediate release market product. 328 pp. Englisch. Codice articolo 9783659665936
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability
Editore:
LAP Lambert Academic Publishing
(2014)
ISBN 10: 3659665932
ISBN 13: 9783659665936
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability
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Descrizione libro PF. Condizione: New. Codice articolo 6666-IUK-9783659665936
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability
Editore:
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(2014)
ISBN 10: 3659665932
ISBN 13: 9783659665936
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Descrizione libro Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Roshdy Fares AhmedAhmed Roshdy Fares, MSc. Teaching and research assistant in Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy - Cairo university. Earned a Master degree in Pharmaceutical Sciences.Buccal deli. Codice articolo 5171312
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability : Formulation and In-vitro / In-vivo Evaluation
Editore:
LAP LAMBERT Academic Publishing
(2014)
ISBN 10: 3659665932
ISBN 13: 9783659665936
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Descrizione libro Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Buccal delivery systems involves the administration of the drug through the buccal mucosal membrane lining of the oral cavity bypassing the first pass effect. Buspirone hydrochloride is an anxiolytic drug which undergoes extensive first-pass metabolism that results in very low oral bioavailability (4%). In addition, buspirone hydrochloride has short and variable elimination half-life (approximately 2.4 h). So it is a good candidate for the preparation of sustained release buccal dosage forms. The aim of this work was to formulate and evaluate buspirone hydrochloride buccal mucoadhesive cup and core tablets and sponges to sustain its action and improve its systemic bioavailability. The results of the in-vivo performance study confirmed that the prepared cup and core buccal tablets succeeded in increasing the bioavailability of buspirone 5.6 folds in comparison to the oral immediate release market product. Codice articolo 9783659665936
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Buccal Systems to Enhance Buspirone Hydrochloride Bioavailability Formulation and Invitro Invivo Evaluation
Editore:
LAP LAMBERT Academic Publishing
(2014)
ISBN 10: 3659665932
ISBN 13: 9783659665936
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PAP
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Descrizione libro PAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo L0-9783659665936
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