Molecular Basis of Nk Cell Recognition and Function: 64 - Rilegato

Rilegato

ISBN 10: 3805563329 ISBN 13: 9783805563321

Casa editrice: S Karger Ag, 1996

Riassunto

Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists.

Su questa edizione

• Editore: S Karger Ag
• Data di pubblicazione: 1996
• ISBN 10: 3805563329
• ISBN 13: 9783805563321
• Rilegatura: Copertina rigida
• Numero di pagine: 184
• Redattore: Moretta Lorenzo