PEGylated-mucin delivery systems containing metformin and vernonia: A novel formulation of an antidiabetic drug using PEGylated-mucin as a delivery agent

 
9783845401669: PEGylated-mucin delivery systems containing metformin and vernonia: A  novel formulation of an antidiabetic drug using PEGylated-mucin as a delivery agent

This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of ≥700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic.

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About the Author:

Dr. Momoh, Mumuni Audu,is an experience hospital pharmacist. Qualified as a pharmacist from Ahmadu Bello Univesity Zaria. He is a holder of Master and Ph.D degree in Pharmaceutics, He lecture at the University of Nigeria Nsukka. Momoh also had a master degree in Public Health, Imo State University Owerri. He is a register Pharmacist

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1.

Mumuni Audu, Momoh
Editore: LAP Lambert Academic Publishing Nov 2011 (2011)
ISBN 10: 3845401664 ISBN 13: 9783845401669
Nuovi Taschenbuch Quantità: 2
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Descrizione libro LAP Lambert Academic Publishing Nov 2011, 2011. Taschenbuch. Condizione libro: Neu. 220x150x14 mm. Neuware - This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of 700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic. 228 pp. Englisch. Codice libro della libreria 9783845401669

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Mumuni Audu, Momoh
Editore: LAP Lambert Academic Publishing Nov 2011 (2011)
ISBN 10: 3845401664 ISBN 13: 9783845401669
Nuovi Taschenbuch Quantità: 2
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Rheinberg-Buch
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Descrizione libro LAP Lambert Academic Publishing Nov 2011, 2011. Taschenbuch. Condizione libro: Neu. 220x150x14 mm. Neuware - This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of 700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic. 228 pp. Englisch. Codice libro della libreria 9783845401669

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Mumuni Audu, Momoh
Editore: LAP Lambert Academic Publishing Nov 2011 (2011)
ISBN 10: 3845401664 ISBN 13: 9783845401669
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Descrizione libro LAP Lambert Academic Publishing Nov 2011, 2011. Taschenbuch. Condizione libro: Neu. 220x150x14 mm. This item is printed on demand - Print on Demand Neuware - This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of 700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic. 228 pp. Englisch. Codice libro della libreria 9783845401669

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Mumuni Audu, Momoh
Editore: LAP Lambert Academic Publishing (2011)
ISBN 10: 3845401664 ISBN 13: 9783845401669
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Descrizione libro LAP Lambert Academic Publishing, 2011. Paperback. Condizione libro: New. Aufl.. 220 x 150 mm. Language: English . Brand New Book. This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of ?700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic. Codice libro della libreria KNV9783845401669

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