This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of ≥700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic.
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Dr. Momoh, Mumuni Audu,is an experience hospital pharmacist. Qualified as a pharmacist from Ahmadu Bello Univesity Zaria. He is a holder of Master and Ph.D degree in Pharmaceutics, He lecture at the University of Nigeria Nsukka. Momoh also had a master degree in Public Health, Imo State University Owerri. He is a register Pharmacist
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Descrizione libro Lap Lambert Academic Publishing, 2011. Condizione libro: New. This item is printed on demand for shipment within 3 working days. Codice libro della libreria KP9783845401669