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PEGylated-mucin delivery systems containing metformin and vernonia: A novel formulation of an antidiabetic drug using PEGylated-mucin as a delivery agent - Brossura
This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of ≥700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic.
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L'autore:
Dr. Momoh, Mumuni Audu,is an experience hospital pharmacist. Qualified as a pharmacist from Ahmadu Bello Univesity Zaria. He is a holder of Master and Ph.D degree in Pharmaceutics, He lecture at the University of Nigeria Nsukka. Momoh also had a master degree in Public Health, Imo State University Owerri. He is a register Pharmacist
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- EditoreLAP LAMBERT Academic Publishing
- Data di pubblicazione2011
- ISBN 10 3845401664
- ISBN 13 9783845401669
- RilegaturaCopertina flessibile
- Numero di pagine228
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PEGylated-mucin delivery systems containing metformin and vernonia
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LAP LAMBERT Academic Publishing Nov 2011
(2011)
ISBN 10: 3845401664
ISBN 13: 9783845401669
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Descrizione libro Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of 700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic. 228 pp. Englisch. Codice articolo 9783845401669
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PEGylated-mucin delivery systems containing metformin and vernonia : A novel formulation of an antidiabetic drug using PEGylated-mucin as a delivery agent
Editore:
LAP LAMBERT Academic Publishing
(2011)
ISBN 10: 3845401664
ISBN 13: 9783845401669
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Taschenbuch
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Descrizione libro Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This study was carried out to assess the pharmacodynamic properties of metformin and Vernonia amygdalina-loaded PEGylated-mucin matrices. Aqueous leaf extract of Vernonia amygdalina was obtained by cold maceration. Phytochemical analysis and LD50 determination were evaluated. Co-polymer matrices containing PEG and mucin in varying ratios were formulated. The particle size (PS), zeta potential (ZP), polydispersity index (PDI) and surface morphology were evaluated. The loaded drugs were evaluated for their blood glucose lowering potentials. Effects on haematological parameters, kidney electrolytes, liver enzymes, bilirubin and CD4+ cells were evaluated and were found very effective in glucose reduction and no negative effect on the other parameters studied. Phytochemical revealed several alkaloids, carbohydrates, tannins, saponins, flavonoids and glycosides, with an LD50 of 700 ± 13 mg/kg. The PDI, ZP, PS values ranges: (0.745 - 1.000), (-18.7- 23.2 mV), (82.4 - 484.5) respectively, the SEM were spherical and smooth. In conclusion, the results demonstrated that the formulation could be a possible alternative for the drug delivery system for the long-term treatment of diabetic. Codice articolo 9783845401669
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PEGylated-mucin delivery systems containing metformin and vernonia
Editore:
LAP LAMBERT Academic Publishing
(2011)
ISBN 10: 3845401664
ISBN 13: 9783845401669
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Descrizione libro Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Mumuni Audu MomohDr. Momoh, Mumuni Audu,is an experience hospital pharmacist. Qualified as a pharmacist from Ahmadu Bello Univesity Zaria. He is a holder of Master and Ph.D degree in Pharmaceutics, He lecture at the University of Nig. Codice articolo 5480331
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Pegylated-Mucin Delivery Systems Containing Metformin And Vernonia: A Novel Formulation Of An Antidiabetic Drug Using Pegylated-Mucin As A Delivery Agent
Editore:
Lap Lambert Academic Publishing
(2011)
ISBN 10: 3845401664
ISBN 13: 9783845401669
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Descrizione libro Paperback. Condizione: Brand New. 228 pages. 8.66x5.91x0.52 inches. In Stock. Codice articolo zk3845401664
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