Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether.
Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
Sanjeev Kumar Shukla is completed his Ph.D. in Biotechnology, B.U. Jhansi,U.P., India, Ramesh Chandra is completed his Ph.D. in Zoology at CDRI, Lucknow, India and S.K.Puri is a Head,Division of Parasitology, CDRI, Lucknow India.
Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.
Spese di spedizione:
EUR 29,99
Da: Regno Unito a: U.S.A.
Spese di spedizione:
EUR 3,57
In U.S.A.
Da: Lucky's Textbooks, Dallas, TX, U.S.A.
Condizione: New. Codice articolo ABLIING23Apr0316110144051
Quantità: Più di 20 disponibili
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
PAP. Condizione: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo IQ-9783848433971
Quantità: 15 disponibili
Da: Ria Christie Collections, Uxbridge, Regno Unito
Condizione: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Codice articolo ria9783848433971_lsuk
Quantità: Più di 20 disponibili
Da: Chiron Media, Wallingford, Regno Unito
PF. Condizione: New. Codice articolo 6666-IUK-9783848433971
Quantità: 10 disponibili
Da: PBShop.store US, Wood Dale, IL, U.S.A.
PAP. Condizione: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice articolo L0-9783848433971
Quantità: Più di 20 disponibili
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether. 64 pp. Englisch. Codice articolo 9783848433971
Quantità: 2 disponibili
Da: AHA-BUCH GmbH, Einbeck, Germania
Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether. Codice articolo 9783848433971
Quantità: 2 disponibili
Da: moluna, Greven, Germania
Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Shukla Sanjeev KumarSanjeev Kumar Shukla is completed his Ph.D. in Biotechnology, B.U. Jhansi,U.P., India, Ramesh Chandra is completed his Ph.D. in Zoology at CDRI, Lucknow, India and S.K.Puri is a Head,Division of Parasitology, CDRI. Codice articolo 5521867
Quantità: Più di 20 disponibili
Da: Mispah books, Redhill, SURRE, Regno Unito
Paperback. Condizione: Like New. Like New. book. Codice articolo ERICA79638484339746
Quantità: 1 disponibili