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Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation - Brossura
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Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnMuscle tissue in higher vertebrates consists of slow twitch (type I) and fast twitch (type II) muscle fibers. This fiber type identity is determined by the set of genes, either type I/slow or type II/fast that the fiber expresses. Codice articolo 68826021
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Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation
Print on DemandDa: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Muscle tissue in higher vertebrates consists of slow twitch (type I) and fast twitch (type II) muscle fibers. This fiber type identity is determined by the set of genes, either type I/slow or type II/fast that the fiber expresses. One of the main transcription factors controlling fiber type identity is Mef2c, which drives the expression of type I/slow genes. However, Mef2c is expressed in both type I/slow and type II/fast fibers. Thus, its activity needs to be differentially regulated in the two different fiber types. Here I report that nTrip6, the nuclear isoform of the LIM-domain protein Trip6, acts as a co-repressor for Mef2c. nTrip6 interacted with Mef2c, it was recruited to Mef2c target promoters, and it repressed Mef2c activity. This novel function of nTrip6 plays a crucial role in the determination of the type II/fast identity. This work further supports the emerging concept that not only the regulation of the expression of transcription factors, but also of transcriptional co-regulators, is essential for the temporal control of gene expression. 108 pp. Englisch. Codice articolo 9783954045235
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Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation
Print on DemandDa: AHA-BUCH GmbH, Einbeck, Germania
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Muscle tissue in higher vertebrates consists of slow twitch (type I) and fast twitch (type II) muscle fibers. This fiber type identity is determined by the set of genes, either type I/slow or type II/fast that the fiber expresses. One of the main transcription factors controlling fiber type identity is Mef2c, which drives the expression of type I/slow genes. However, Mef2c is expressed in both type I/slow and type II/fast fibers. Thus, its activity needs to be differentially regulated in the two different fiber types. Here I report that nTrip6, the nuclear isoform of the LIM-domain protein Trip6, acts as a co-repressor for Mef2c. nTrip6 interacted with Mef2c, it was recruited to Mef2c target promoters, and it repressed Mef2c activity. This novel function of nTrip6 plays a crucial role in the determination of the type II/fast identity. This work further supports the emerging concept that not only the regulation of the expression of transcription factors, but also of transcriptional co-regulators, is essential for the temporal control of gene expression. Codice articolo 9783954045235
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Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation
Editore:
Cuvillier, Cuvillier Okt 2013, 2013
ISBN 10: 3954045230
ISBN 13: 9783954045235
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Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
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Taschenbuch. Condizione: Neu. Neuware -Muscle tissue in higher vertebrates consists of slow twitch (type I) and fast twitch (type II) muscle fibers. This fiber type identity is determined by the set of genes, either type I/slow or type II/fast that the fiber expresses. One of the main transcription factors controlling fiber type identity is Mef2c, which drives the expression of type I/slow genes. However, Mef2c is expressed in both type I/slow and type II/fast fibers. Thus, its activity needs to be differentially regulated in the two different fiber types. Here I report that nTrip6, the nuclear isoform of the LIM-domain protein Trip6, acts as a co-repressor for Mef2c. nTrip6 interacted with Mef2c, it was recruited to Mef2c target promoters, and it repressed Mef2c activity. This novel function of nTrip6 plays a crucial role in the determination of the type II/fast identity. This work further supports the emerging concept that not only the regulation of the expression of transcription factors, but also of transcriptional co-regulators, is essential for the temporal control of gene expression.Books on Demand GmbH, Überseering 33, 22297 Hamburg 108 pp. Englisch. Codice articolo 9783954045235
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