Rilegato

ISBN 10: 8870512525 ISBN 13: 9788870512526

Casa editrice: edi.ermes, 2003

Why not simply reprint the old one? However, as in the past, biomolecular advances have to a large extent been stimulated by something that was "seen" in the first place. The concept of programmed cell death is a case in point. In fact, it is difficult to believe that the very word "apoptosis" cannot be found in the previous two editions of Atlas! While the morphologic hallmarks i.e., chromatin condensation and fragmentation of the nucleus into "nuclear bodies" had been observed, they have only been correlated recently with the characteristic "ladder" pattern of DNA fragmentation as detected by electrophoresis. Many other examples could be cited.On the other hand, even with advances made in visual detection methods, such as immuno-electron microscopy and fluorescent in situ hybridization for the identification of chromosomal abnormalities, many of the advances have depended almost completely on biochemical methods. The new edition of the Atlas includes these observations by representing them diagrammatically. While an effort was made to limit the size of this publication, it was found that few of the original illustrations should be omitted. On the other hand, there are more than 400 new illustrations contributed by a worldwide consortium of biomedical scientists. To them the editors express their gratitude. Finally, it is our sad mission to acknowledge the inspiring help of our late publisher, Dr. Italo Grandi, who conceived this Atlas in the first place. Dr. Grandi, more than anyone else in this endeavor, appreciated the synergy between art and science. The Atlas of Blood Cells: Function and Pathology should stand as a monument to that vision. This is a 2 volume set.