ISBN 10: 044463486X / ISBN 13: 9780444634863
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Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: This book is expected to have a high impact and shape further development of the large neuroscience community. Codice inventario libreria

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In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

  • Authors are the leading experts in the field of brain extracellular matrix in health and disease
  • Book covers the most important aspects of brain extracellular matrix in health and disease
  • Interesting for both scientists and clinicians

About the Author: Dr. Pitkänen is currently a Professor of Neurobiology at the University of Eastern Finland in Kuopio, Finland. She has over a 30 years’ experience in working and developing animal models of acquired epilepsy and phenotyping of epilepsy models, using histologic and molecular analysis, behavioral tests, long-term video-EEG and MRI imaging. She is a leader in epilepsy research and has participated in several NINDS on Epilepsy Models Workshops and worked in several ILAE Committees related to preclinical modelling and use of models to develop better therapies for epilepsy. She has an h-index of 52 and has over 279 publications.

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Alexander Dityatev
Editore: Oxford Elsevier LTD Feb 2015 (2015)
ISBN 10: 044463486X ISBN 13: 9780444634863
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Descrizione libro Oxford Elsevier LTD Feb 2015, 2015. Buch. Condizione libro: Neu. Neuware - In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. 358 pp. Englisch. Codice libro della libreria 9780444634863

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Alexander Dityatev
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Descrizione libro Oxford Elsevier LTD Feb 2015, 2015. Buch. Condizione libro: Neu. Neuware - In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. 358 pp. Englisch. Codice libro della libreria 9780444634863

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Alexander Dityatev (volume editor), Bernhard Wehrle-Haller (volume editor), Asla Pitkänen (volume editor)
Editore: Elsevier Science 2014-11-05, Amsterdam (2014)
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Descrizione libro Elsevier Science 2014-11-05, Amsterdam, 2014. hardback. Condizione libro: New. Codice libro della libreria 9780444634863

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Dityatev, Alexander (Editor)/ Wehrle-haller, Bernhard (Editor)/ Pitkänen, Asla (Editor)
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Descrizione libro Elsevier Science Serials, 2014. Hardcover. Condizione libro: Brand New. 1st edition. 472 pages. 9.50x7.75x1.25 inches. In Stock. Codice libro della libreria __044463486X

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Editore: ELSEVIER SCIENCE TECHNOLOGY, United Kingdom (2015)
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Descrizione libro ELSEVIER SCIENCE TECHNOLOGY, United Kingdom, 2015. Hardback. Condizione libro: New. Language: English . Brand New Book. In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. Codice libro della libreria AA59780444634863

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Editore: ELSEVIER SCIENCE TECHNOLOGY, United Kingdom (2015)
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Descrizione libro ELSEVIER SCIENCE TECHNOLOGY, United Kingdom, 2015. Hardback. Condizione libro: New. Language: English . Brand New Book. In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. Codice libro della libreria AA59780444634863

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Descrizione libro Elsevier, 2014. Condizione libro: New. Codice libro della libreria L9780444634863

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Alexander Dityatev, Bernhard Wehrle-Haller
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Descrizione libro Elsevier Science & Technology. Hardback. Condizione libro: new. BRAND NEW, Brain Extracellular Matrix in Health and Disease, Alexander Dityatev, Bernhard Wehrle-Haller, In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. * Authors are the leading experts in the field of brain extracellular matrix in health and disease* Book covers the most important aspects of brain extracellular matrix in health and disease * Interesting for both scientists and clinicians. Codice libro della libreria B9780444634863

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Descrizione libro 2014. Hardcover. Condizione libro: New. Hardcover. In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, alo.Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. 506 pages. 1.238. Codice libro della libreria 9780444634863

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Dityatev, Alexander (Editor)/ Wehrle-haller, Bernhard (Editor)/ Pitkänen, Asla (Editor)
Editore: Elsevier Science Serials (2014)
ISBN 10: 044463486X ISBN 13: 9780444634863
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Descrizione libro Elsevier Science Serials, 2014. Hardcover. Condizione libro: Brand New. 1st edition. 472 pages. 9.50x7.75x1.25 inches. In Stock. Codice libro della libreria z-044463486X

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