Cancer Genome and Tumor Microenvironment

Thomas-tikhonenko, Andrei (EDT)

Editore: Springer Verlag, 2009
ISBN 10: 1441907106 / ISBN 13: 9781441907103
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Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

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“This book compiles recent works on genetic alterations that have been associated with carcinogenesis and attempts to present these in the context of the interaction of tumor cells with their microenvironment. The book provides a great deal of information on specific subjects of research, and is very useful as a reference. ... The audience includes scientists and physicians involved in basic and translational research.” (Khashayarsha Khazaie, Doody’s Review Service, July, 2010)

“This book amends a space of nowaday cancer bibliography in the area of tumor microenvironment as it provides detailed overview of crucial steps of tumorigenesis. Book consists of 20 chapters that are divided into 4 main parts in addition to introductory editor’s part providing short characteristics of particular chapters and closing one. ... The book is very useful for PhD students and for all researchers who intend to be more oriented in advances of molecular oncology. Therefore the book is highly recommended.” (J. Sedlák, Neoplasma, February, 2011)

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Dati bibliografici

Titolo: Cancer Genome and Tumor Microenvironment
Casa editrice: Springer Verlag
Data di pubblicazione: 2009
Legatura: Hardcover
Condizione libro: New

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Thomas-Tikhonenko, Andrei [Editor]
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Descrizione libro Springer, 2009. Hardcover. Condizione: New. Codice articolo INGM9781441907103

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Descrizione libro Springer-Verlag New York Inc., United States, 2010. Hardback. Condizione: New. 2010 ed.. Language: English . Brand New Book. Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late 80s-early 90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are soft-wired , i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Codice articolo LIB9781441907103

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Descrizione libro 2009. HRD. Condizione: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Codice articolo KS-9781441907103

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Editore: Springer-Verlag New York Inc., United States (2010)
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Descrizione libro Springer-Verlag New York Inc., United States, 2010. Hardback. Condizione: New. 2010 ed.. Language: English . Brand New Book. Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late 80s-early 90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are soft-wired , i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Codice articolo LIB9781441907103

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Thomas-Tikhonenko, Andrei
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Descrizione libro Springer, 2016. Paperback. Condizione: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Codice articolo ria9781441907103_lsuk

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Descrizione libro Springer New York 2009-12-14, New York, 2009. hardback. Condizione: New. Codice articolo 9781441907103

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Andrei Thomas-Tikhonenko
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Descrizione libro Springer-Verlag Gmbh Dez 2009, 2009. Buch. Condizione: Neu. Neuware - Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are 'soft-wired', i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors. 480 pp. Englisch. Codice articolo 9781441907103

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Andrei Thomas-Tikhonenko
Editore: Springer-Verlag Gmbh Dez 2009 (2009)
ISBN 10: 1441907106 ISBN 13: 9781441907103
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Descrizione libro Springer-Verlag Gmbh Dez 2009, 2009. Buch. Condizione: Neu. Neuware - Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are 'soft-wired', i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors. 480 pp. Englisch. Codice articolo 9781441907103

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Andrei Thomas-Tikhonenko
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BuchWeltWeit Inh. Ludwig Meier e.K.
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Descrizione libro Springer-Verlag Gmbh Dez 2009, 2009. Buch. Condizione: Neu. Neuware - Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are 'soft-wired', i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors. 480 pp. Englisch. Codice articolo 9781441907103

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