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Riassunto: Over the past ten years several sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been found to be very useful in characterizing the permeability of drugs across epithelial tissues, and in studying formulations or carrier systems for improved drug delivery and enhanced absorption. Compared to in vivo trials on animals or humans, cell culture models are faster, more convenient and cost effective, ethically advantageous and, most importantly, they can be more easily standardized and validated.
This book provides a practical approach to contemporary cell culture-based in vitro techniques for drug transport studies at biological absorption barriers. It is an invaluable source of information for students attending graduate courses on this subject and pharmaceutical scientists working in industry or in academia.
Contenuti: General Aspects of Epithelial Cell and Tissue Culture. Basic Aspects of Cell Growth and Cell Cycle in Culture. Cell Culture Media: Selection and Standardization. Bioelectrical Characterization of Epithelial Cell (Mono)Layers and Tissues. Characterization of Transport Over Epithelial Barriers. Studying Cellular Binding and Uptake of Bioadhesive Lectins. High-throughput Epithelial Cell Culture Systems for Screening Drug Intestinal Permeability. Good Cell Culture Practice (GCCP). Regulatory Acceptance of in vitro Test Systems as an Alternative to Safety Testing in Animals. Regulatory Acceptance of in vitro Permeability Studies in the Context of the Biopharmaceutics Classification System. Models of Specific Epithelial and Endothelial Barriers Relevant to Drug Delivery. Caco-2 Cell Monolayers as a Model for Studies of Drug Transport Across Human Intestinal Epithelium. Transport Studies Using Intestinal Tissue ex vivo. Models of Alveolar Epithelium. Bronchial Epithelial Cell Cultures. In vitro Methodologies to Study Nasal Delivery Using Excised Mucosa. Cell Culture Models of the Corneal and Conjunctival Epithelium. Cell Cultures of the Retinal Pigment Epithelium to Model the Blood-retina Barrier for Retinal Drug and Gene Delivery. Human Skin and Skin Equivalents to Study Dermal Penetration and Permeation. In vitro Models of the Human Buccal Epithelium: the TR146 Cell Culture Model and the Porcine in vitro Model. Drug Transport Across the Blood-brain Barrier: A Molecular and Functional Perspective. BeWo Cells: An in vitro System Representing The Blood-placental Barrier. Emerging Tools for Studying Biological Barriers and Drug Transport. Predicting Drug Absorption by Computational Methods. Confocal and Two-photon Fluorescence Microscopy. On the Application of Scanning Force Microscopy in Cell Biology. Fluorescence Correlation Spectroscopy.
Titolo: Cell Culture Models of Biological Barriers
Casa editrice: CRC Press
Data di pubblicazione: 2002
Condizione libro: New
Descrizione libro CRC Press, 2002. Hardcover. Condizione: Used: Good. Codice articolo SONG0415277248
Descrizione libro CRC Press, 2002. HRD. Condizione: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Codice articolo F9-9780415277242
Descrizione libro Taylor & Francis, 2002. Hardcover. Condizione: Brand New. 1st edition. 452 pages. 9.50x7.00x0.75 inches. In Stock. Codice articolo __0415277248
Descrizione libro CRC Press, 2018. Hardback. Condizione: NEW. 9780415277242 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Print on Demand title, produced to the highest standard, and there would be a delay in dispatch of around 10 working days. For all enquiries, please contact Herb Tandree Philosophy Books directly - customer service is our primary goal. Codice articolo HTANDREE0194429
Descrizione libro CRC Press, 2002. Condizione: New. book. Codice articolo M0415277248