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Cell Cycle Deregulation in Cancer

Greg H. Enders

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ISBN 10: 1441917691 / ISBN 13: 9781441917690
Editore: Springer-Verlag Gmbh Apr 2010, 2010
Nuovi Condizione: Neu Buch
Da Rhein-Team Lörrach Ivano Narducci e.K. (Lörrach, Germania)

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Neuware - Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy. 206 pp. Englisch. Codice inventario libreria 9781441917690

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Titolo: Cell Cycle Deregulation in Cancer

Casa editrice: Springer-Verlag Gmbh Apr 2010

Data di pubblicazione: 2010

Legatura: Buch

Condizione libro:Neu

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Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy. TOC:Escape from cellular quiescence.- Interplay between Cyclin-dependent Kinases and E2F-dependent Transcription.- Regulation of pre-RC assembly: A complex symphony orchestrated by CDKs.- Mitotic checkpoint and chromosome instability in cancer.- Mitotic catastrophe.- p53, ARF and the control of autophagy.- Regulation of self-renewing divisions in normal and leukaemia stem cells.- Maintenance of Telomeres in Cancer.- The senescence secretome and its impact on tumor suppression and cancer.- Cell cycle deregulation in pre-neoplasia: case study of Barrett's esophagus.- Targeting cyclin dependent kinases for cancer therapy.-

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