ISBN 10: 3659116335 / ISBN 13: 9783659116339
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Riassunto: The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness.

About the Author: Naveen Patel: He did his masters in pharma Technology. His areas of interest are targeted drug delivery,nanoparticulate technology and enhancement of solubility by self emulsification.Aparna Lanka: She did her masters in pharma Technology. She did projects on colon targeted delivery and mucoadhesive delivery by lectins.

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Descrizione libro LAP Lambert Academic Publishing, 2012. PAP. Condizione libro: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Codice libro della libreria LQ-9783659116339

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Descrizione libro LAP Lambert Academic Publishing, 2016. Paperback. Condizione libro: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Codice libro della libreria ria9783659116339_lsuk

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Descrizione libro LAP LAMBERT Academic Publishing, 2012. Paperback. Condizione libro: New. book. Codice libro della libreria 3659116335

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Descrizione libro LAP Lambert Academic Publishing, Germany, 2012. Paperback. Condizione libro: New. Aufl.. Language: English . Brand New Book ***** Print on Demand *****.The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness. Codice libro della libreria AAV9783659116339

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Descrizione libro LAP LAMBERT Academic Publishing. Paperback. Condizione libro: New. Paperback. 104 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6: 4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Codice libro della libreria 9783659116339

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