ISBN 10: 0123743737 / ISBN 13: 9780123743732
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This Book is in Good Condition. Clean Copy With Light Amount of Wear. 100% Guaranteed. Summary: I. OVERVIEW OF CHLORIDE TRANSPORTERS AND CHANNELS CHAPTER 1 CHLORIDE TRANSPORT: A HISTORIC PERSPECTIVE. A) CHLORIDE CHANNELS. Criss Hartzell (Emory University). B) CHLORIDE CARRIERS Cation-chloride cotransporters NKCC (J. Russell, Syracuse University) KCC (Peter Lauf ,Wright State University) Anion exchangers (David Mount, Harvard University) Neurotransmitter cotransporters (Susan Amara, University of Pittsburgh) CHAPTER 2 THERMODYNAMIC AND KINETIC ASPECTS OF CHLORIDE TRANSPORT (F.J. Alvarez-Leefmans (Wright State University), J. Payne (UC Davis), and E. Delpire (Vanderbilt University). CHAPTER 3 CURRENT METHODS FOR STUDYING CHLORIDE REGULATION A) FLUORESCENT DYES (Alan Verkman, University of San Francisco, California) B) CHLOMELION (George Augustine & Thomas Kuner, University of North Carolina) C) GRAMICIDIN PERFORATED PATCH (Norio Akaike, University of Kumamoto, Japan) D) CHLORIDE FLUXES IN HETEROLOGOUS EXPRESSION SYSTEMS (Gerardo Gamba, National University of Mexico, Mexico) E) KNOCKOUT MODELS OF CATION CHLORIDE COTRANSPORTERS (Eric Delpire, Vanderbilt University) II. FROM CLONING TO STRUCTURE, FUNCTION AND REGULATION OF CHLORIDE TRANSPORTERS AND CHANNELS CHAPTER 4 THE ClC FAMILY OF CHLORIDE CHANNELS (T. Jentch, University of Hamburg, Germany). CHAPTER 5 CALCIUM ACTIVATED CHLORIDE CHANNELS (Criss Hartzell, Emory University) CHAPTER 6 NEUROTRANSMITTER-ACTIVATED CHLORIDE CHANNELS (Robert MacDonald, Vanderbilt University) CHAPTER 7 THE PUZZLE OF VOLUME ACTIVATED ANION CHANNELS (B. Nilius, University of Leuven). CHAPTER 8 THE CATION CHLORIDE COTRANSPORTER FAMILY (G. Gamba, National University of Mexico, Mexico, and J. Payne, University of California, Davis). CHAPTER 9 THE ANION EXCHANGERS (David Mount, Harvard University and Michael Romero, Case Western Reserve, Cleveland) CHAPTER 10 CHLORIDE IN THE TRANSPORT OF NEUROTRANSMITTERS (Susan Amara, University of Pittsburgh) CHAPTER 11 REGULATION OF CATION-CHLORIDE COTRANSPORTERS (G. Gamba, National University of Mexico, Mexico and E. Delpire Vanderbilt University) III. CHLORIDE TRANSPORTERS IN NERVOUS SYSTEM DEVELOPMENT CHAPTER 12 ROLE OF CATION-CHLORIDE COTRANSORTERS IN THE DEVELOPEPMENT OF THE NERVOUS SYSTEM (K. Kaila, University of Helsinki, Finland) CHAPTER 13 THROPHIC ROLES OF GABA IN NERVOUS SYSTEM DEVELOPMENT. (Y. Ben-Ari Y., Marseille, France) CHAPTER 14 ROLE OF GLYCINE IN THE DEVELOPMENT OF THE AUDITORY BRAINSTEM (E. Friauf, Kaiserslautern, Germany and K. Kandler, University of Pittsburgh). CHAPTER 15 GABA, GLYCINE AND CATION-CHLORIDE COTRANSPORTERS IN RETINAL FUNCTION AND DEVELOPMENT (Noga Vardi, University of Pennsylvania). IV. CATION-CHLORIDE COTRANSPORTERS IN NEURAL FUNCTION AND DYSFUNCTION CHAPTER 16 TRANSDUCTION IN OLFACTORY NEURONS (S. Frings, University of Heidelberg, Germany) CHAPTER 17 VESTIBULAR AND COHLEAR FUNCTION AND DYSFUNCTION (D.C. Marcus and P. Wangemann, Kansas State University, Manhattan, KS) CHAPTER 18 MUTATIONS IN KCC3 AND NERVE DYSFUNCTION (G. Rouleau, McGill University, Montreal, Canada) CHAPTER 19 PRESYNATIC INHIBITION, PAIN AND INFLAMMATION (F. J. Alvarez-Leefmans, Wright State University, Dayton, OH and W. Willis, University of Texas Medical Branch, Galveston TX) CHAPTER 20 EPILEPSY (K. Staley, University of Colorado) CHAPTER 21 BRAIN ISCHEMIA (D. Sun, University of Wisconsin, Madison, WI) CHAPTER 22 CHLORIDE TRANSPORT IN GLIOMA CELL INVASION (H.W. Sontheimer, University of Alabama, Birmingham, AL) CHAPTER 23 CYTOMEGALOVIRUS, CELL GROWTH AND NKCC (J. Russell, Syracuse University, N.Y.) V. CATION-CHLORIDE COTRANSPORT IN CHOROID PLEXUS AND AND BLOOD BRAIN BARRIER CHAPTER 24 CHLORIDE TRANSPORTERS AS WATER PUMPS (Thomas Zeuthen and Stephen Hamann, Copenhaguen, Denmark) CHAPTER. Codice inventario libreria

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Riassunto: The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

* The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years
* Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control.
* The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation.
* Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.
* Involves all of the leading researchers in the field.
* INcludes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field.

Dal retro di copertina:

Chloride ions play a key role in the nervous system. They are integral to functions such as synaptic inhibition, neuronal development, sensory transduction and homeostasis of brain fluids and electrolytes. Over the last 10 to 15 years the spectacular growth of molecular biology and the advent of new optical and electrophysiological methods have resulted in exciting new information about the molecular structure and function of chloride channels and carriers and their involvement in various diseases. Chloride transport proteins have become potential pharmacological targets for the treatment of conditions as diverse as epilepsy, pain, neurogenic inflammation, tumor growth and invasion, and brain edema.

This is the first book to provide a coherent and comprehensive review of our current knowledge of the mechanisms by which chloride ions cross the membranes of nerve, glial and epithelial cells. Each chapter presents fundamental concepts and detailed information about the molecular structure and function of carriers and channels involved in chloride transport, as well as discussion of their role in various neurological diseases. Authors identify areas where more work is needed within this exponentially expanding field of cellular and molecular neurobiology, and provide extensive information on state-of-the-art methods available for studying chloride transport and regulation.

    • Written by recognized leading experts, and carefully edited and cross-referenced to provide a coherent presentation

    • Illustrated with high quality color drawings and photographs

    • Integrates emerging concepts in the field of chloride transporters and channels, from molecules to diseases

    • A valuable resource for researchers in neuroscience, molecular and cell biology, and for non-specialists wishing to enter the field

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